Significance of Heparin-Binding Protein and D-dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis by Tomasz Mikuła, Mariusz Sapuła, Joanna Jabłońska, Joanna Kozłowska, Wojciech Stańczak, Dagny Krankowska, Alicja Wiercińska-Drapało

“…A D-dimer cutoff value of 1500 ng/mL was determined optimal for ruling out SBP due to high sensitivity (96.8%) and a high negative predictive value (92.9%), although predictably, this marker was not useful for confirming SBP due to low specificity (40.6%) and a low positive predictive value (61.2%). …”
Get full text

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Results The exposure-response relationships between meteorological factors and HFRS incidence revealed significant heterogeneity across epidemic regions, as evidenced by Cochran’s Q test for temperature (Q = 324.40, P < 0.01) and relative humidity (Q = 30.57, P < 0.01). The optimal daily average temperature for HFRS transmission in Rattus-dominant epidemic regions (− 6.6 °C), characterized by spring epidemics, was lower than that observed in Apodemus-dominant epidemic regions (13.7 °C), where primary cases occurred during autumn and winter months. …”
Get full text

Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…The XGBoost hyperparameter optimized model had an AUC score of .85 on the test set. …”
Get full text

Qualitative Insights on Barriers to Receiving a Second Dose of Measles-Containing Vaccine (MCV2), Oromia Region of Ethiopia by Kalkidan Solomon, Brooke N. Aksnes, Abyot Bekele Woyessa, Chala Gari Sadi, Almea M. Matanock, Monica P. Shah, Paulos Samuel, Bekana Tolera, Birhanu Kenate, Abebe Bekele, Tesfaye Deti, Getachew Wako, Amsalu Shiferaw, Yohannes Lakew Tefera, Melkamu Ayalew Kokebie, Tatek Bogale Anbessie, Habtamu Teklie Wubie, Aaron Wallace, Ciara E. Sugerman, Mirgissa Kaba

“…<b>Introduction</b><b>:</b> Ethiopia introduced a second dose of measles-containing vaccine (MCV2) in 2019 to provide further protection against measles and further progress toward elimination. However, the sub-optimal coverage of both MCV1 and MCV2 suggest challenges with vaccine uptake. …”
Get full text

Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a... by Larissa dos Santos Leonel, Ingrid Alessandra Victoria Wolin, Angélica Danielevicz, Mabel Diesel, Marina Isolde Constantini, João Batista de Oliveira Junior, Allana Andrade Souza, Thaís Reichert, João Gabriel Silveira-Rodrigues, Danusa Dias Soares, Marcelo Fernando Ronsoni, Simone Van De Sande Lee, Alex Rafacho, Guilherme Fleury Fina Speretta, Karla Siqueira Lottermann, Josefina Bertoli, Alexandre Pastoris Muller, Aline Mendes Gerage, Cíntia de La Rocha Freitas, Rodrigo Sudatti Delevatti

“…Moreover, this could support the development of intervention strategies to optimize the T2D management. Trial registration Brazilian Clinical Trial Registry (ReBEC) RBR-10fwqmfy. …”
Get full text

Tracheostomy Practice in the Italian Intensive Care Units: A Point-Prevalence Survey by Raffaele Merola, Maria Vargas, Filippo Sanfilippo, Marco Vergano, Giovanni Mistraletti, Luigi Vetrugno, Gennaro De Pascale, Elena Giovanna Bignami, Giuseppe Servillo, Denise Battaglini

“…The high prevalence and notable complication rates emphasize the urgent need for standardized clinical protocols aimed at optimizing patient outcomes and minimizing adverse events. …”
Get full text

Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial by Jordan M. Cloyd, MD, Rakhsha Khatri, BA, Angela Sarna, BS, Lena Stevens, PhD, Victor Heh, PhD, Mary Dillhoff, MD, Alex Kim, MD, Timothy M. Pawlik, MD, PhD, MPH, Aslam Ejaz, MD, Sharla Wells-Di Gregorio, PhD, Erin Scott, MD, Sachin S. Kale, MD

“…Given the unique and complex care needs of this patient population, additional research is needed to optimize supportive care strategies.…”
Get full text

Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…Integration of the recommendations is intended to promote optimal evaluation and management of patients with ID, regardless of the presence of anaemia. …”
Get full text

Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

“…Functional assays, including glucose tolerance tests and insulin tolerance tests, were optimized for individual axolotls. To assess pancreatic gene function, Pdx1 mutants were generated using CRISPR/Cas9-mediated gene editing, and their effects on pancreatic morphology, endocrine cell populations, and glucose homeostasis were analyzed.ResultsThe axolotl pancreas contains all known pancreatic cell types and develops from dorsal and ventral buds. …”
Get full text

Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…Abstract Introduction Immune check-point inhibitors (ICI) were a major breakthrough in cancer care, but optimal patient selection remains elusive in most tumors. …”
Get full text

Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Abstract Background Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood. …”
Get full text

Combination of the endoscopic septonasal flap technique and bioabsorbable steroid-eluting stents for repair of congenital choanal atresia in neonates and infants: a retrospective s... by Peng-peng Wang, Li-xing Tang, Jie Zhang, Xiao-jian Yang, Wei Zhang, Yang Han, Xiao Xiao, Xin Ni, Wen-tong Ge

“…However, there remains no general consensus about the optimal surgical technique. This study aimed to describe and evaluate outcomes of the endoscopic septonasal flap technique combined with bioabsorbable steroid-eluting stents for repair of congenital choanal atresia in neonates and infants. …”
Get full text

Whole genome sequencing of a novel carrageenan-degrading bacterium Photobacterium rosenbergii and oligosaccharide preparation by Jing Chen, Jing Chen, Runmin Chen, Kit-Leong Cheong, Zhuo Wang, Rui Li, Xuejing Jia, Qiaoli Zhao, Xiaofei Liu, Bingbing Song, Saiyi Zhong, Saiyi Zhong

“…GDSX-4 exhibited remarkable carrageenan-degrading activity, with a specific enzyme activity of 46.94 U/mg. Optimal hydrolysis conditions were determined to be 40°C and pH 7.0, with the enzyme retaining 80% of its activity below 30°C and across a pH range of 4.0–10.0. …”
Get full text

Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide by Catherine E. Myers, Catherine E. Myers, Rokas Perskaudas, Rokas Perskaudas, Vibha Reddy, Chintan V. Dave, Chintan V. Dave, John G. Keilp, Arlene King, Kailyn Rodriguez, Kailyn Rodriguez, Lauren St. Hill, Rachael Miller, Alejandro Interian, Alejandro Interian

“…Computational modeling was used to estimate latent cognitive variables including learning rates from positive and negative outcomes, and the subjective value of ambiguous feedback.ResultsOptimal responding on the reward-based trials was positively associated with upcoming ASA, and remained predictive even after controlling for other standard clinical variables such as current suicidal ideation severity and prior suicide attempts. …”
Get full text

Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Future studies should expand on these findings to optimize care and guide therapeutic strategies.…”
Get full text

Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Methods: We used unsupervised clustering to integrate plasma biomarker data from two prospective cohorts of CS patients: CardShock (N = 205 [2010–2012, NCT01374867]) and the French and European Outcome reGistry in Intensive Care Units (FROG-ICU) (N = 228 [2011–2013, NCT01367093]) to determine the optimal number of classes. Thereafter, a simplified classifier (Euclidean distances) was used to assign the identified CS subphenotypes in three completed randomized controlled trials (RCTs) (OptimaCC, N = 57 [2011–2016, NCT01367743]; DOREMI, N = 192 [2017–2020, NCT03207165]; and CULPRIT-SHOCK, N = 434 [2013–2017, NCT01927549]) and explore heterogeneity of treatment effect with respect to 28-day mortality (primary outcome). …”
Get full text

Strong-lensing Analysis of SPT-CL J2325−4111 and SPT-CL J0049−2440, Two Powerful Cosmic Telescopes (RE > 40″) from the SPT Clusters Sample by Guillaume Mahler, Keren Sharon, Matthew Bayliss, Lindsey. E. Bleem, Mark Brodwin, Benjamin Floyd, Raven Gassis, Michael D. Gladders, Gourav Khullar, Juan D. Remolina González, Arnab Sarkar

“…The lens models of SPT-CL J2325−4111 and SPT-CL J0049−2440 were optimized using nine and eight secure multiply imaged systems with a final image-plane rms of 0 $\mathop{.}…”
Get full text

Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…Multiple regression and spatial analysis of yield, water use efficiency, and lycopene content indicated that, under micro-nano aeration, irrigation volumes between 445.700–446.833 mm, combined with 0.492–0.498 % HA, represent optimal irrigation strategies. These conditions ensured that yield (278.03–281.21 t ha–1), WUE (0.57–0.58 t ha–1 mm–1), lycopene content (56.28–56.76 mg kg–1), and Vc content (56.06–56.19 mg 100 g–1) remained above 95 % of their maximum values.…”
Get full text

Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients by Qila Sa, Qila Sa, Yinghui Zhou, Guangming Cheng, Boyuan Nan, Yingnan Feng, Yingnan Feng, Ningyuan Zhang, Ningyuan Zhang, Wantao Xie, Wantao Xie, Wei Zhang

“…However, a debate regarding which of these surgical methods is optimal has been ongoing. Aim of this study is to compare medical costs and final outcomes associated with the three surgical approaches for the entire treatment duration, aiming to identify the most cost-effective surgical method.MethodsBased on previous research data from domestic and international studies, as well as data from on-site surveys, TreeAge Pro 2022 software was used to construct a Markov model for the surgical treatment of SHPT patients. …”
Get full text

Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…Conclusions: Assessing ovarian reserve is crucial for predicting pregnancy outcomes, optimizing ART protocols, and guiding reproductive decisions. …”
Get full text