Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Background For patients with advanced non-small cell lung carcinoma (NSCLC), immune checkpoint inhibitor (ICPI) and chemotherapy (chemo) ICPI represent two distinct first-line standard-of-care regimens without clear and established biomarkers to inform the optimal choice for individual patients. Here, we examined the complementary roles of tumor mutational burden (TMB) and programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) to inform first-line therapy using a large real-world (rw) data set.Materials and methods The study included patients with NSCLC from an rw de-identified clinico-genomic database. …”
Get full text

Crystalloid resuscitation is associated with decreased treatment delays and improved systolic blood pressures in a blood-constrained setting by Melissa Carvalho, Alain Chichom-Mefire, Catherine Juillard, S Ariane Christie, Rasheedat Oke, Thompson Kinge, Jean-Gustave Tsiagadigui, Mbiarikai A Mbianyor, Mark T Yost, Matt Driban, Fanny Nadia Dissak Delon, Richard Njock, Daniel Nkusu

“…CB prior to definitive hemorrhage control in this resource-limited setting may be a necessary strategy to optimize perfusion pressure.Level of evidence and study type III, retrospective study.…”
Get full text

External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Currently, there is no consensus regarding the optimal treatment for high-risk, non-metastatic prostate cancer (PCa). …”
Get full text

Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…This opens doors to research on optimal combinations for individual patients.…”
Get full text

Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We performed stage-specific transcriptomic profiling to identify differentially expressed key functional gene groups that relate to these functions and provide a fundamental understanding of the mechanisms S. molnari uses to optimize its parasitic lifestyle. We aimed to identify genes that are likely related to parasite pathogenicity and host cell exploitation mechanisms, and we hypothesize that genes unique to S. molnari might be indicative of evolutionary innovations and specific adaptations to host environments. …”
Get full text

Form factors of $$\varLambda _b^0 \rightarrow \varLambda _c(2595)^+$$ Λ b 0 → Λ c ( 2595 ) + within light-cone QCD sum rules by Hui-Hui Duan, Yong-Lu Liu, Qin Chang, Ming-Qiu Huang

“…Furthermore, by combining these form factors with the helicity amplitudes of the bottom baryon transition matrix elements, we calculated the differential decay widths for the processes $$\varLambda _b^0 \rightarrow \varLambda _c(2595)^+\ell ^-\bar{\nu }_\ell $$ Λ b 0 → Λ c ( 2595 ) + ℓ - ν ¯ ℓ and provided the optimal choice of the interpolating current for $$\varLambda _c$$ Λ c in this process. …”
Get full text

Impact of Mating Methods and Semen Preservation on Reproductive and Growth Performances in Palestinian Assaf Sheep by Wael Halaweh, Samia Khnissi, Ikram Ben Souf, Muayad Salman, Naceur M’Hamdi

“…These findings provide valuable insights for sheep farmers in the region to optimize reproductive strategies and enhance lamb production…”
Get full text

Otomatisasi Pembangkitan Pertanyaan untuk Bahasa Indonesia (Systematic Literature Review) by Mohammad Farid Naufal, Selvia Ferdiana Kusuma

“…The SLR that was built can be used for consideration of optimizing research on generating questions using Indonesian in the future. …”
Get full text

Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…Five ML models were trained to predict signaling pathways, with Grid Search optimizing hyperparameters and 5-fold cross-validation ensuring unbiased performance. …”
Get full text

The importance of specific exercise therapy in pediatric oncology by Bianca Celine Schmidli, Céline Hammadou, Christina Schindera, Nicolas von der Weid, Uta Tacke, Oliver Faude, Sarah Koch, Fiona Streckmann

“…This approach not only improves quality of life but also contributes positively to the optimal course of treatment. Discussion/Conclusion We hypothesized that children who maintain their motor and sensory functions (e.g. balance, jumping) through physical activity will maintain age-appropriate development, improve their quality of life and facilitate social reintegration after therapy. …”
Get full text

Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…The inclusion of this biomarker not only optimizes patient management but also aligns with the growing emphasis on precision in medical interventions.Keywords: Systemic inflammatory response Index, Type B aortic intramural hematoma, biomarkers, nomogram, prognosis…”
Get full text

Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post‐discharge by Patrick Rossignol, Renaud Fay, Nicolas Girerd, Faiez Zannad

“…Whether acting on these events may help optimizing renin angiotensin aldosterone system inhibitors and diuretic therapy warrants further dedicated testing. …”
Get full text

Translation and Validation of the Edinburgh Postnatal Depression Scale for Eritrea: A Screening Tool for Postpartum Depression in Primary Health Care Facilities by Gebregziabher NK, Netsereab TB, Alazar FA, Fessaha YG, Sium AH, Ghebrehiwet NK

“…The area under the receiver operating characteristic curve was 0.87, and optimal sensitivity and specificity combination was found at 10/11 score cut-off points, 85.7% and 88%, respectively.Conclusion: The Eritrean version of EPDS has proven to be a valid and reliable instrument for the identification of postpartum depression in clinical settings.Plain language summary: Postpartum depression (PPD) is a significant concern affecting new mothers worldwide. …”
Get full text

Evaluation of mineral and near-infrared forecasting of wheat yield varieties using spectrophotometric techniques by H.A. Pardhe, N. Krishnaveni, B.K. Chekraverthy, S. Patel, S. Naveen, V. Rashmi, P.C. Govinden

“…The acquired results bridge the intricate relationship between plant-based diets, micronutrient deficiencies, providing valuable insights into combating iron deficiencies in public health with the potential achievement of improved nutritional understanding, optimized wheat selection, advanced analytical techniques, education, awareness, and iron deficiency mitigation.…”
Get full text

Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…Lastly, with respect to DAS28, resveratrol emerged as the optimal choice (74.3%).ConclusionAccording to the network meta-analysis (NMA), curcumin exhibited superior efficacy compared to placebo in decreasing SJC and TJC. …”
Get full text

Analisis Strategi Pemasaran Politik Kampanye Kukuh Haryanto Sebagai Calon Legislatif DPRD Kabupaten Wonogiri Dalam Kontestasi Pemilihan Umum Tahun 2024 by Shildamullah Danendra Mukti Ardana, Titin Purwaningsih

“…Namun, ia tidak berhasil meraih kursi legislatif karena tingginya kompetisi serta perolehan suara partai yang kurang optimal.…”
Get full text

Attention to Monkeypox: An Interpretable Monkeypox Detection Technique Using Attention Mechanism by Avi Deb Raha, Mrityunjoy Gain, Rameswar Debnath, Apurba Adhikary, Yu Qiao, Md. Mehedi Hassan, Anupam Kumar Bairagi, Sheikh Mohammed Shariful Islam

“…Therefore, the development of optimized deep learning models that are both resource-efficient for edge computing and highly accurate becomes imperative. …”
Get full text

Fabrication of tin nanoparticles with functionalized platinum nanodendrites on ITO electrode for simultaneous detection of Cd2+, Pb2+, and Cu2+ ions by Nurul Hidayah Ramli, Noorhashimah Mohamad Nor, Zainovia Lockman, Khairunisak Abdul Razak

“…The produced electrode was subjected to cyclic voltammetry (CV) in 5.0 × 10−3 mol/L potassium ferrocyanide, [Fe (CN)6]3−, in a 0.1 mol/L KCl solution (pH 7.0) and square wave anodic stripping voltammetry (SWASV) in 0.2 M acetate buffer solution (pH 4.5). The optimized electrode, namely, Nafion/7 µL PtND-CA-SnNP/ITO, demonstrated high sensitivity and selectivity and successfully detected Cd(II), Pb(II), and Cu(II) ions during simultaneous detection with linear ranges of 1–5 ppb for low concentration and 10–100 ppb for high concentration. …”
Get full text

Pengukuran Tingkat Kapabilitas Sistem Pengolahan Data Survei Pada Manajamen Kinerja Dan Manajemen Data Operasi Menggunakan Dmbok Dan Cobit2019 Di BPS RI by Siti Mawar Rini Wintang, Yova Ruldeviyani, Joko Parmiyanto, Freddy Richard Putra Hulu, Azanisa Putri, Rifta Dimas Sulistiyo

“…Based on the results of this study, recommendations have been made to optimize the Capability Level in both Performance Management and Data Operations Management of ICS so that it can be run properly in accordance with the goals of digital transformation of BPS. …”
Get full text

Research on equity analysis and forecasting of nursing human resource allocation in Jiangxi Province, China by Yunyu Du, Zhiqin Xie, Zhen Yang, Wanyin Xiong, Li Zhou, Min Zhang, Suhua Zeng, Min Wang

“…These findings provide a foundation for optimizing future nursing resource allocation to ensure equitable access to healthcare services.…”
Get full text