Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Using random matrix theory to denoise datasets, we have established reference cell type classifications for the normal mouse and human prostate and have used optimal transport to compare the cross-species transcriptomic similarities of epithelial cell populations. …”
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Prevalence of Computer Vision Syndrome and Associated Factors among Instructors in Ethiopian Universities: A Web-Based Cross-Sectional Study by Demisu Zenbaba, Biniyam Sahiledengle, Mitiku Bonsa, Yohannes Tekalegn, Jember Azanaw, Vijay Kumar Chattu

“…Working in third-generation universities, being female, age, frequently working on the computer, and sitting in bent back position were statistically significant predictors in computer vision syndrome. Therefore, optimizing exposure time, addressing ergonomic hazards associated with computer usage through on-the-job and off-the-job training, and making the safety guidelines accessible for all university instructors would be critical to address the problem.…”
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Barriers and Facilitators to the Preadoption of a Computer-Aided Diagnosis Tool for Cervical Cancer: Qualitative Study on Health Care Providers’ Perspectives in Western Cameroon by Magali Jonnalagedda-Cattin, Alida Manoëla Moukam Datchoua, Virginie Flore Yakam, Bruno Kenfack, Patrick Petignat, Jean-Philippe Thiran, Klaus Schönenberger, Nicole C Schmidt

“…The aim was to guide smooth technology adoption in similar settings by identifying specific barriers and facilitators and optimizing CAD’s potential benefits while minimizing obstacles. …”
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Vermicomposting of coir pith and cow manure: Influence of initial total phenolic content on earthworms’ performance by Kanokwan Pundee, Saengchai Akeprathumchai, Sudarut Tripetchkul

“…Highlight The initial phenolic concentration of coir pith exhibited antagonistic effects on earthworm activities. The optimal initial phenolic content of the feedstock was the key to the successful vermicomposting of phenolic-rich agricultural wastes. …”
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Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative Study by Christina L Duncan, Emily F Muther, Jennifer J Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L Harrison, Deepika Polineni

“…The diverse community partner input was critical in optimizing and tailoring our telecoaching intervention. …”
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Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet by Lisa Torsdatter Markussen, Jemina Kivelä, Jaana Lindström, Miina Ollikainen, Mikko Kytö, Seppo Heinonen, Saila Koivusalo, Jelena Meinilä

“…Abstract Background Gestational Diabetes Mellitus (GDM) prevalence is rising worldwide, but optimal dietary strategies remain unclear. The eMOM pilot RCT compared a plant-protein rich Healthy Nordic Diet (HND) and a moderately carbohydrate restricted diet (MCRD) and their potential effects on time in glucose target range (≤ 7.8 mmol/L, %TIR), and on newborn body composition. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…This study provides a potentially optimal framework for future research on valve diseases and surgeries using claims databases.…”
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Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting by Stefania Ronzoni, Shamim Rashid, Aimee Santoro, Elad Mei-Dan, Jon Barrett, Nanette Okun, Tianhua Huang

“…It underscores the need for broader adoption and enhanced infrastructure to optimize patient care and outcomes across diverse healthcare settings. …”
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A User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study by Michael Zeiler, Nikolas Dietzel, Fabian Haug, Julian Haug, Klaus Kammerer, Rüdiger Pryss, Peter Heuschmann, Elmar Graessel, Peter L Kolominsky-Rabas, Hans-Ulrich Prokosch

“…This research highlights the significance of a user-centered design approach, allowing content, text, and design to be optimally tailored to the needs of the target audience. …”
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Influence of light quality on the profiling of metabolites and the status of Lactobacillus community in the phyllosphere of hydroponically grown ginseng by Nooruddin Bin Sadiq, Ji-Eun Lee, Muhammad Hamayun, Seda Nur Kabadayı, Na-Yun Park, Bokyung Lee, Ho-Youn Kim

“…This study provides valuable insights into optimizing ginseng cultivation for both enhanced metabolite production and microbiome health. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…Thin and uniform NFs with a smooth surface and standard size (<400 nm) were observed by SEM at the optimized 5:5 (GEL:PVA) volumetric ratio. FTIR analyses confirmed the drug loading into BNFs. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…This understanding equips health care to address barriers, optimize adoption, and leverage telemedicine’s potential for sustainable clinical integration.…”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…Furthermore, E6020 is a single molecule, well-characterized fully synthetic TLR4 agonist constructed in eight synthetic steps from entirely crystalline starting materials and intermediates via an optimized high-yield synthetic route. Overall, our data suggest that SPA14 is a viable, easy-to-manufacture, potent novel adjuvant system that could be broadly applicable as a ready-to-mix adjuvant in the form of a long-term stable liquid formulation.…”
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The The effectiveness of galangal Alpinia galanga extract for the treatment of sangkuriang catfish Clarias gariepinus infected Aeromonas hydrophila by Yuli Andriani, Desy Setyo Wati, Irfan Zidni, Roffi Grandiosa Herman

“… The purpose of this research is to find out the optimal dose of galangal extract to treatment of Sangkuriang catfish infected with Aeromonas hydrophila, the fish fry used are 5-7 cm in size. …”
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No rumen fermentation profiles and associated microbial diversities difference were found between Hu sheep and Karakul sheep fed a cottonseed hull diet by Jishu Wang, Guangxu E, Meng Zhang, Yanlong Zhang, Tiantian Bai, XuanXuan Pu, Junfeng Liu, Xuefeng Guo, Subir Sarker, Long Cheng

“…These results provide a scientific basis for further understanding the rumen function of sheep and for optimizing their feeding strategies. Video Abstract…”
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Humic acid improves water retention, maize growth, water use efficiency and economic benefits in coastal saline-alkali soils by Ge Li, Yuyang Shan, Weibo Nie, Yan Sun, Lijun Su, Weiyi Mu, Zhi Qu, Ting Yang

“…Furthermore, the function analysis of WUE and ∆NP identified the optimal HA application rates as 193.5 kg ha−1 and 182.3 kg ha−1, respectively. …”
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Integrating Hybrid Team-Based and Case-Based Learning in Dental Education Transformation by Sidra Abid, Humna Rafiq

“…However, challenges such as resource availability and the need for comprehensive reviews of existing methodologies must be addressed to optimize the implementation of this hybrid pedagogy.7 Conclusively, integrating CBL with team-based learning cultivates a more competent and adaptable dental workforce, better prepared for real-world clinical scenarios. …”
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Exploring how graft length shapes root system architecture and morphology in grapevine rootstocks by Mathieu Larrey, Jean-Pascal Tandonnet, Clément Saint Cast, Sarah Jane Cookson, Philippe Vivin

“…The insights gathered here contribute to a deeper understanding of the mechanisms governing root development in grafted grapevines, thereby informing strategies to enhance grafting techniques and optimize grapevine cultivation. …”
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Modelling and Analysis of Bioretention Systems for Removal of Stormwater Pollutants by Nuwagaba, Emmanuel, Abdulkadir, Taofeeq Sholagberu, Agwe, Michael Tobby, Philip, Tibenderana, Ako, Terseer, Moses N., Twesigye-omwe

“…However, the selection of appropriate media structure, plants performance in bio retention system, and optimized design have not been adequately researched. …”
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Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations by María Piñeiro-Ramil, Iván Gómez-Seoane, Ana Isabel Rodríguez-Cendal, Isaac Fuentes-Boquete, Silvia Díaz-Prado

“…However, challenges remain in optimizing and standardizing sEVs isolation, dosage, and delivery methods for clinical application. …”
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