Opioids in Urology: How Well Are We Preventing Opioid Dependence and How Can We Do Better? by Danyon J. Anderson, David Y. Cao, Jessica Zhou, Matthew McDonald, Abrahim N. Razzak, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…However, many institutions recognize their opioid overuse and are implementing new multimodal opioid-sparing analgesics methods such as non-opioid peri-operative medications, minimally invasive robotic surgery, and nerve blocks or local anesthetics with varying degrees of success. …”
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Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…Long term administration of an opioid drug for chronic nonmalignant pain continues to be controversial, but is no longer uniformly rejected by pain specialists. …”
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Opioid Sparing Analgesics in Spine Surgery by Logan A. Reed, Mihir Patel, Kevin Luque, Steven M. Theiss

“…Combinations of various nonopioid analgesics have been used to decrease pain and opioid consumption postoperatively allowing for faster recovery, improved patient satisfaction, and decreased morbidity. …”
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Effect of Opioid on Adult Hippocampal Neurogenesis by Yue Zhang, Horace H. Loh, Ping-Yee Law

“…We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.…”
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Is otologic surgery contributing to the opioid epidemic? by Valerie Dahm, Justin T. Lui, Rudolfs Liepins, Joseph M. Chen, Trung N. Le, Christoph Arnoldner, Vincent Y. W. Lin

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Opioid System and Epithelial–Mesenchymal Transition by Marzena Łazarczyk, Dominik Skiba, Michel-Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk

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Dynamics of agonist-evoked opioid receptor activation revealed by FRET- and BRET-based opioid receptor conformation sensors by Sina B. Kirchhofer, Claudia Kurz, Lorenz Geier, Anna-Lena Krett, Cornelius Krasel, Moritz Bünemann

“…Abstract The opioid receptor family, particularly the µ opioid receptor, are the main drug targets in the management of severe pain. …”
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Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

Subjects: “…Opioid use disorder…”
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Dexmedetomidine as Part of a Multimodal Analgesic Treatment Regimen for Opioid Induced Hyperalgesia in a Patient with Significant Opioid Tolerance by Richard K. Patch III, Jason S. Eldrige, Susan M. Moeschler, Matthew J. Pingree

“…A multimodal approach is key; however other factors can complicate management such as opioid induced hyperalgesia. We present the case of a patient on large amounts of intrathecal opioids for chronic pain syndrome with opioid induced hyperalgesia after an exploratory laparotomy. …”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

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Role of Opioid Ligands in the Irritable Bowel Syndrome by Enrico Corazziari

“…Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system. …”
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Opioid-induced pancreatitis: A case study by Anuka Koul, Jaspreet Kaur, Sahil Attri, Navneet Arora

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Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review by Brian Hutton, Beverley Shea, Kimberly Corace, David Moher, Danielle B Rice, Becky Skidmore, Kednapa Thavorn, Sheena Taha, Dianna Wolfe, Fatemeh Yazdi, Beth A Sproule, Melanie Willows, Patricia Poulin, Gary Garber, Amy Porath, Leila Esmaeilisaraji

“…Introduction The opioid crisis has resulted in increasing rates of death caused by problematic opioid use. …”
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Spinal NGF Restores Opioid Sensitivity in Neuropathic Rats: Possible Role of NGF as a Regulator of CCK-Induced Anti-Opioid Effects by Catherine M Cahill, Terence J Coderre

“…Chronic pain emanating from a nerve injury is typically refractory to traditional analgesics such as opioids. Recent evidence suggests that supplementation of spinal NGF restores morphine-induced antinociception in an animal model of neuropathic pain. …”
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Prevalence of Opioid Dispensings and Concurrent Gastrointestinal Medications in Quebec by Rachel E Williams, Nevzeta Bosnic, Carolyn T Sweeney, Ashlee W Duncan, Kristen B Levine, Michael Brogan, Suzanne F Cook

“…BACKGROUND: Opioids are frequently prescribed for moderate to severe pain. …”
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Chronic Noncancer Pain and the Long Term Utility of Opioids by CPN Watson, JH Watt-Watson, ML Chipman

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Detection of opioid growth factor in Multiple Sclerosis Patients by Khamael Abdulla Taha, Mayada N. Iqbal, Gheyath Abd Ali Shalal

Subjects: “…Multiple sclerosis( MS) ; Opioid growth factor(OGF) ; body mass index(BMI)…”
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Curing Opioid Toxicity with Intrathecal Targeted Drug Delivery by Thomas P. Pittelkow, Markus A. Bendel, Jacob J. Strand, Susan M. Moeschler

“…Herein, we discuss a case of opioid-induced neurotoxicity treated with intrathecal targeted drug delivery (TDD). …”
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Treatment of Neuropathic Pain: Focus on Antidepressants, Opioids and Gabapentin by C Peter N Watson, Judith H Watt-Watson

“…Mistaken beliefs about many of these treatments are prevalent and need to be dispelled. Opioids are increasingly being used for the refractory patient. …”
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Comment on: “Multimodal opioid-free anesthesia versus opioid-based anesthesia for patients undergoing cardiac valve surgeries: A randomized controlled trial.” by Leena Tayshete, Jaffrey Kalaiselvan, Rohan Magoon

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