Reply to: Comments on “a comparative study of sexual behavior, dysfunction, satisfaction, relationship, and sexual quality of life amongst treatment naïve and abstinent men (buprenorphine-maintained) with opioid (heroin) dependence syndrome” by Mahadev Singh Sen, Ankita Chattopadhyay, Nishtha Chawla, Ragul Ganesh, Suraj Verma, Siddharth Sarkar, Atul Ambekar

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mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized patients with methamphetamine use and opioid use disorder by Elenore P. Bhatraju, Devin N. Kennedy, Alexander J. Gojic, Matthew Iles-Shih, Joseph O. Merrill, Jeffrey H. Samet, Kevin A. Hallgren, Judith I. Tsui

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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approved with reservations] by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

Subjects: “…Opioids…”
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The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine by Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy

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Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

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“There’s always somebody that you can identify with”: a qualitative study of patient perspectives on buprenorphine group medical visits by Mariya Masyukova, Benjamin T. Hayes, Teresa López-Castro, Aaron D. Fox

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Effects of a Serratus Anterior Plane Block After Video-Assisted Lung Wedge Resection: A Single-Center, Prospective, and Randomized Controlled Trial by Seokjin Lee, Tae-Yun Sung, Choon-Kyu Cho, Gyuwon Lee, Woojin Kwon

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Complementary Approaches to Postoperative Pain Management: A Review of Non-pharmacological Interventions by Emery Niyonkuru, Muhammad Asad Iqbal, Xu Zhang, Peng Ma

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Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review by Abhijit S. Nair, Indira Gurajala, Nitinkumar Borkar, Ujjwalraj Dudhedia, Manamohan Rangaiah, Sandeep Diwan

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Methods of forensic examination of Nalbuphine by I. О. Besedina

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Bridging the pain gap after cancer surgery – Evaluating the feasibility of transitional pain service to prevent persistent postsurgical pain – A systematic review and meta-analysis... by Raghu S. Thota, S Ramkiran, Aveek Jayant, Koilada Shiv Kumar, Anjana Wajekar, Sadasivan Iyer, M Ashwini

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COVID-19 in India: Health implications and treatment needs of people who use drugs (PWUD) and patients with substance use disorders (SUD) by Gautam Kr GHOSH

Subjects: “…substance use disorders; treatment; opioid substitution therapy…”
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Comparison of efficacy of ultrasound-guided erector spinae plane block versus thoracolumbar interfascial plane block in patients undergoing lumbar spine surgeries: A systematic rev... by Siddhavivek Majage, Rajathadri Hosur Ravikumar, Mrudula Prasanna, M Chandramouli, Priyankar Kumar Datta, Dalim Kumar Baidya

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A Need for Further Education on Buprenorphine in Pain Medicine by Jamal Hasoon, Anvinh Nguyen, Ivan Urits, Christopher Robinson, Omar Viswanath, Alan D Kaye

“…With the ongoing opioid epidemic in the United States there has been a strong transition towards utilizing multi-modal analgesia, interventional procedures, and non-opioid medications when managing acute and chronic pain. …”
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Neurostimulation as an Efficacious Nonpharmacologic Analgesic following Arthroscopic Rotator Cuff Repair by Ryan B. Juncker, Joel J. Gagnier, Faisal M. Mirza

“…This case highlights the importance of pursuing nonpharmacologic analgesic modalities in orthopedic surgery to combat the current opioid epidemic. Presented is a patient who underwent an arthroscopic rotator cuff repair and biceps tenodesis operation and through the use of neurostimulation (in the form of auricular electrostimulation), fully recovered from surgery without the usage of any opioid or nonsteroidal anti-inflammatory medications. …”
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Cost of Intravenous Analgesia for the Management of Acute Pain in the Emergency Department is Substantial in the United States by Pamela P. Palmer, Judith A. Walker, Asad E. Patanwala, Carin A. Hagberg, John A. House

“…**Background:** Pain is a leading cause of admission to the emergency department (ED) and moderate-to-severe acute pain in medically supervised settings is often treated with intravenous (IV) opioids. With novel noninvasive analgesic products in development for this indication, it is important to assess the costs associated with IV administration of opioids. …”
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Dexamethasone as an Analgesic Adjunct for Postcesarean Delivery Pain: A Randomized Controlled Trial by Jennifer E. Mehdiratta, Jennifer E. Dominguez, Yi-Ju Li, Remie Saab, Ashraf S. Habib, Terrence K. Allen

“…The primary outcome was cumulative opioid consumption at 24 h. Secondary outcomes included cumulative opioid consumption at 48 h, time to first analgesic request, and pain scores at rest and on movement at 2, 24, and 48 h. …”
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Clinical and Economic Outcomes Associated With Use of Liposomal Bupivacaine Versus Standard of Care for Management of Postsurgical Pain in Pediatric Patients Undergoing Spine Surge... by Robert Tracy Ballock, John Seif, Ryan Goodwin, Jennifer H. Lin, Jessica Cirillo

“…Pain following spine surgery may affect opioid exposure, length of stay (LOS), and costs in hospitalized pediatric patients. …”
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Buprenorphine and its formulations: a comprehensive review by Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan D Kaye

“…Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. …”
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Acute Cytotoxic Cerebellar Edema Subsequent to Fentanyl Patch Intoxication in an Infant by Lindsey N. Haut, Rupa Radhakrishnan, Riad Lutfi, Louise W. Kao, Laurie L. Ackerman

“…The opioid epidemic continues to have devastating consequences for children and families across the United States with rising prevalence of opioid use and abuse. …”
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