An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray by Handong Ouyang, Shue Liu, Weian Zeng, Roy C. Levitt, Keith A. Candiotti, Shuanglin Hao

“…., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. …”
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Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication by Sarah Allam, Elizabeth Paris, Itzel Lazcano, Pincas Bitterman, Sanjib Basu, James O’Donnell, Animesh Barua

“…However, as the opioids are becoming a source of addiction, additional pain medication is urgently needed. …”
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The Impact of Preoperative Opioid Use Disorder on Complications and Costs following Primary Total Hip and Knee Arthroplasty by Jacob M. Wilson, Kevin X. Farley, Matthew Aizpuru, Eric R. Wagner, Thomas L. Bradbury, George N. Guild

“…Multiple studies have demonstrated that patients taking opioids in the preoperative period are at elevated risk for complications following total hip (THA) and knee (TKA) arthroplasty. …”
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Estimating the Prevalence of Opioid use Disorder in the Cincinnati Region using Probabilistic Multiplier Methods and Model Averaging by Peter J. Mallow, Nila Sathe, Michael Topmiller, Jennifer Chubinski, Dillon Carr, Roni Christopher

“…**Background:** Opioid use disorder (OUD) and its consequences have strained the resources of health, social, and criminal justice services in the Cincinnati region. …”
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Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis by Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS

“…To assess the relationship between postoperative opioid consumption and frailty status. Background:. …”
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Nommer les lieux de la crise des opioïdes à Boston : un enjeu politique by Elsa Vivant

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Opioid Nonadherence Risk Prediction of Patients with Cancer-Related Pain Based on Five Machine Learning Algorithms by Jinmei Liu, Juan Luo, Xu Chen, Jiyi Xie, Cong Wang, Hanxiang Wang, Qi Yuan, Shijun Li, Yu Zhang, Jianli Hu, Chen Shi

“…Objectives. Opioid nonadherence represents a significant barrier to cancer pain treatment efficacy. …”
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Identifying Priority Areas for Increasing the Supply of Medication-Assisted Treatments for Opioid Use Disorder: A Geospatial Approach by Michael Topmiller, Peter J. Mallow, Aaron T. Vissman, Jene Grandmont

“…**Background:** The opioid epidemic has disproportionately affected several areas across the United States (US), with research indicating that these areas may be underserved and lack access to sufficient medication-assisted treatment (MAT) options. …”
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The Use of Opioids and Pain Medications in the Management of Postoperative Pain in Total Knee Arthroplasty Patients: A Retrospective Study by Ammar Almustafa, Asdghig Der-Boghossian, Abdel Majid Sheikh Taha

“…Purpose. The opioid crisis amplified the concern for the appropriate use of opioids. …”
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Assessment of knowledge and behaviors of an opioid overdose education and naloxone distribution program during the coronavirus disease 2019 pandemic by Alexis E. Horace, Ojochogwu Atawodi-Alhassan

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Association between chiropractic spinal manipulation for sciatica and opioid-related adverse events: A retrospective cohort study. by Robert J Trager, Zachary A Cupler, Roshini Srinivasan, Elleson G Harper, Jaime A Perez

“…<h4>Background</h4>Patients receiving chiropractic spinal manipulation (CSM) for spinal pain are less likely to be prescribed opioids, and some evidence suggests that these patients have a lower risk of any type of adverse drug event. …”
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Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery by S.R. Maruniak, O.A. Loskutov, O.M. Druzhyna, I.R. Malish, N.V. Korotchuk

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Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit by Mohammed Naeem, Hala Al Alem, Ali Al Shehri, Majed Al-Jeraisy

“…Dextromethorphan has no effect on opioid requirement for control of acute pain in children admitted with acute critical care illness in PICU. …”
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Mixed-methods study to examine the response of opioid addiction treatment programmes to COVID-19: a study protocol by Sugy Choi, Rhea Naik, Kamila Kiszko, Charles Neighbors, Thomas D’Aunno

“…This paper describes the protocol for a mixed-methods study analysing organisational-level factors that are associated with changes in clinic-level practice changes and treatment retention.Methods and analysis We will employ an explanatory sequential mixed-methods design to study the treatment practices for opioid use disorder (OUD) patients in New York State (NYS). …”
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The Long-Term Safety and Efficacy of Opioids: A Survey of 84 Selected Patients with Intractable Chronic Noncancer Pain by C Peter N Watson, Judy Watt-Watson, Mary Chipman

“…BACKGROUND: The use of opioids for chronic noncancer pain (CNCP) remains controversial. …”
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Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study by Mhd Wasem Alsabbagh, BScPhm, PhD, Michael A. Beazely, BSP, PhD, Leona Spasik, PharmD

“…This study examined whether there is an association between opioid-related mortality and surgical procedures. …”
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How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis by Quinn Grundy, Fiona Webster, Daniel Z Buchman, Sheryl Spithoff, Ross E G Upshur, Abhimanyu Sud, Matthew Strang

“…Failing to address these conflicts potentially imperils efforts of mitigating population health harms by propagating an important driving force of the opioid crisis.…”
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Historical Pathways for Opioid Addiction, Withdrawal with Traditional and Alternative Treatment Options with Ketamine, Cannabinoids, and Noribogaine: A Narrative Review by Amber N. Edinoff, Natalie W. Wu, Catherine A. Nix, Bryce Bonin, Rama Mouhaffel, Stephen Vining, William Gibson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan D. Kaye

“…Even as prescription opioid dispensing rates have begun to decrease, the use of illicit opioids such as heroin and fentanyl has increased. …”
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Acute Pain Burden and Opioid Dose Requirements after Cesarean Delivery in Parturients with Preexisting Chronic Back Pain and Migraine by Ryu Komatsu, Michael G. Nash, Kenneth C. Ruth, William Harbour, Taylor M. Ziga, Shane Mandalia, Emily M. Dinges, Davin Singh, Hani El-Omrani, Joseph Reno, Brendan Carvalho, Laurent A. Bollag

“…Preoperative opioid use (P<0.001), smoking (P=0.004), and lower postoperative ibuprofen dose (P=0.002) were associated with greater opioid dose requirements. …”
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Efficacy of intranasal naloxone compared to other administration routes in prehospital opioid overdose management and beyond: a narrative review by Luigi Venuso, Francesco Ricciardi, Antonio Del Prete, Michele Virgolesi, Gianluca Pucciarelli, Luigi Langella, Teresa Rea

Subjects: “…Opioid overdose…”
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