Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective Cross-Sectional Study by Peiró AM, Barrachina J, Escorial M, Aguado I, Margarit C, Grimby-Ekman A

“…Being older than 65 years old, retired or on medical leave, under opioids and anxiolytic prescription, had a severe impact on daily quality of life without any sex-difference.Conclusion: These clusters based on real-world clinical information might be useful for screening even more where the access to physical exploration is limited. …”
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Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain by Mohammad Alsalem, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Belal Azab, Aala Dweik, Amer Imraish, Khalid El-Salem

“…Currently used analgesics such as opioids are associated with adverse effects; urging the need for safer alternatives. …”
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Optimising the secondary use of primary care prescribing data to improve quality of care: a qualitative analysis by Robert A Verheij, Niek Klazinga, Erica Barbazza, Lotte Ramerman, Dionne Kringos

“…We anchored our investigation around three tracer prescription types: antibiotics; benzodiazepines and opioids. Descriptive and explanatory themes were derived from interview data using thematic analysis.Setting Stakeholders were sampled from across the micro (clinical), meso (organisational) and macro (policy) contexts of the Dutch primary care system.Participants The study involved 28 informants representing general practitioners (GPs), community pharmacists, regional chronic care networks (care groups), academia and research institutes, insurers, professional associations, electronic health record (EHR) vendors and national authorities.Results In the Netherlands, three main sources of data for improving prescribing in primary care are in use: clinical data in the EHRs of GP practices; pharmacy data in community pharmacy databases and claims data of insurers. …”
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Non-invasive electroencephalogram-based anesthesiological monitoring in geriatric patients in the ent-surgery by Medhat H. Altoufaili, Tatiana V. Klypa, Irina A. Mandel, Maria S. Orekhova

“…The optimization of the dosage of opioids with controlling the anesthesia depth index (the Nociception Index, qNOX) positively affects the postoperative cognitive status of the patients.…”
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Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study by Daniel Widarsson Norbeck, Sophie Lindgren, Axel Wolf, Pether Jildenstål

“…Using traditional clinical variables, such as heart rate, systolic blood pressure, and respiratory rate, to assess and manage nociceptive responses is often insufficient and could lead to overtreatment with both anesthetics and opioids. This study evaluated the feasibility and effectiveness of three nociception monitoring techniques Nociception Level Index (NOL), Skin Conductance Algesimeter (SCA) and heart rate monitoring in patients undergoing image-guided, minimally invasive abdominal interventions under general anesthesia. …”
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Parturient on Magnesium Infusion and Its Effectiveness as an Adjuvant Analgesic after Cesarean Delivery: A Retrospective Analysis by Tanmay H. Shah, Abby R. Rubenstein, Edward S. Kosik, Stephen W. Heimbach, Abhinava S. Madamangalam

“…Perioperative use of intravenous magnesium as part of multimodal analgesia has been increasing in recent years in an effort to decrease the use of opioids. The aim of this study was to evaluate the effectiveness of magnesium sulfate infusion in lowering analgesic requirement and decreasing the intensity of pain score after cesarean delivery. …”
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Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly—A Subgroup Analysis of Routine Clinical Practice Data by Andreas Schwittay, Melanie Sohns, Birgit Heckes, Christian Elling

“…The favorable tolerability profile in particular suggests tapentadol PR as a treatment option before classical strong opioids are considered.…”
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The McGill University Health Centre Cancer Pain Clinic: A Retrospective Analysis of an Interdisciplinary Approach to Cancer Pain Management by Jordi Perez, Sara Olivier, Emmanouil Rampakakis, Manuel Borod, Yoram Shir

“…The total consumption of opioids remained stable; however, the consumption of short acting preparations decreased by 52% whereas the prescription of nonopioid agents increased. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…Acupuncture analgesia is associated with downregulating glutamate in the ascending excitatory pathway and upregulating opioids, 𝛾-aminobutyric acid, norepinephrine, and 5-hydroxytryptamine in the descending pain modulatory system. …”
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Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis by Lu Chen, Lu Chen, Pengxiang Zhou, Pengxiang Zhou, Zhengqian Li, Ziyang Wu, Suodi Zhai, Suodi Zhai

“…For safety outcomes, the synthesized results indicated that opioids were associated with a higher risk of adverse events (AEs), while no severe AEs were observed.ConclusionModerate-to-low certainty evidence indicated that granisetron and oxycodone may represent the optimal intervention for reducing the risk of overall and moderate-to-severe EIM with a reasonable safety profile, providing the potential interventions for clinical practice.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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Electrocatalytic detection of Acetaminophen by sodium ferrite by Saima Perveen, Jameel Ahmed Baig, Mohammad Nur-e-Alam, Mohsin Kazi, Shahabuddin Memon, Tasneem Gul Kazi, Khalil Akhtar, Sajjad Hussain

“…Acetaminophen (APN) is a safer alternative to opioids and is recognized for its analgesic and antipyretic properties. …”
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A randomized controlled interventional study for analgesic effects of intrathecal versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine by Manu Dadhwal, Anupama Gupta, Ajay Kurian

“…Background: Various pharmacologic agents such as opioids, benzodiazepines, ketamine, and alpha2 adrenergic agonists are commonly used to increase the duration of subarachnoid block. …”
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Risk factors for postoperative ileus in hysterectomy: A systematic review and meta-analysis. by Zhuoer Hou, Ting Liu, Xiaoyan Li, Hangpeng Lv, Qiuhua Sun

“…Personal factors and previous history of disease factors of postoperative ileus in hysterectomy patients included use opioids (OR = 3.91, 95%CI: 1.08-14.24), dysmenorrhea (OR = 2.51, 95%: 1.25-5.05), smoking (OR = 1.55, 95%: 1.18-2.02), prior abdominal or pelvic surgery (OR = 1.46, 95%CI: 1.16-1.83) and age (OR = 1.03, 95%: 1.02-1.04). …”
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Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review. by Mahima Joshi, Javed Muneer, Lawrence Mbuagbaw, Ipsita Goswami

“…The most frequently used pharmacological agents are opioids (Morphine, Fentanyl), benzodiazepine (Midazolam) and Alpha2 agonists (Dexmedetomidine). …”
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Predictive Factors for Access-Site Pain Chronicity after Percutaneous Coronary Intervention via Radial Artery Access by Liuda Brogiene, Giedre Baksyte, Agne Klimaite, Martynas Paliokas, Andrius Macas

“…Pain control was performed with Ketoprofen and Ibuprofen as most used NSAIDs. 10 mg of Morphine intravenously was the choice from strong opioids if necessary. Conclusions. The prevalence of chronic A-S pain is 3.7%. …”
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Comparison of Nasopharyngeal Airway with Endoscopic Respiratory Mask for Hypoxemia in Painless Gastrointestinal Endoscopy in Obese Outpatients: Study Protocol for a Randomized Cont... by Xiang D, Deng L, Zhou R, Zhang X, Tian L, Jiang W, Zhou Y, Chen W, Peng Y

“…All patients in two groups will receive propofol and opioids for procedural sedation. The primary outcome will be the incidence of hypoxemia. …”
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Early removal of indwelling urinary catheters in children undergoing abdominal tumor resection with epidural analgesia by Shachi Srivatsa, Jennifer H. Aldrink, Dana Schwartz, Grant Heydinger, Andrew Davidoff, Andrew J. Murphy, Kyle O. Rove, Sara A. Mansfield

“…EA was at T12 level or higher in 101 patients (97.1 %) in the early group, and 68 (54.8 %) in the late group (p<0.001). EA contained opioids in 27 (26.0 %) in the early group and 54 (43.5 %) in the late group (p=0.005). …”
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Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial by Ali Kendal Oğuz, Celaleddin Soyalp, Yunus Emre Tunçdemir, Arzu Esen Tekeli, Nureddin Yüzkat

“…Propofol, while widely used, has significant limitations, including respiratory depression, hemodynamic instability, and delayed recovery when higher doses are required for adequate sedation. The addition of opioids to propofol, though beneficial for analgesia, introduces risks such as hypoxemia and hypotension. …”
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Comparison of analgesic efficacy of diclofenac suppository with intramuscular diclofenac sodium in post-operative pain relief after cesarean delivery in the first 24 hours by Sidra Khan, Noreen Majeed, Ruqya, Mehreen Mehdi, Faiza Safdar, Saana Bibj

“…Different analgesics with  various routes of administrations are available for pain relief which include opioids and NSAIDS. Opiods are known for their undesireable side effects . …”
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Shared genetic risk and causal associations between Post-traumatic stress disorder and migraine with antithrombotic agents and other medications by Charlotte K. Bainomugisa, Dagmar Bruenig, Heidi G. Sutherland, Lyn R. Griffiths, Dale R. Nyholt, Divya Mehta

“…The genetic liability to PTSD had a causal effect on increased risk of using pain medication such as opioids (βivw = 0.59, P = 5.21 x 10−5) while the genetic liability to migraine had a causal effect on the increased risk of using anti-thrombotic agents (βivw = 0.59, P = 1.69 x 10−7). …”
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