Jack London and White Fang: a lost struggle by Zilberstein, Gleb, Zilberstein, Svetlana, Rocco, Richard M., Righetti, Pier Giorgio

“…Despite the claims by his biographers that he used opium, morphine, and heroin on a regular basis this assertion could not be confirmed by the chemical analyses of the objects here tested. Only two opioids were discovered, morphine and diacetylmorphine (heroin) both of which could have been derived from the use of common, legal (over-the-counter) flu and cough medications.…”
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Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial by Julian Ojebo, Joseph Achi, Ifeanyichukwu Michael Chukwu, Osadebamen Mercy Oboh, Benedict Ezeife, Aisha Sanusi Muazu, Christian Osemudiamen Igibah, Salami Ezekiel Kelvin

“…Conclusion: The combination of nefopam and dexamethasone is equipotent to the combination of pethidine and dexamethasone in pain control after cesarean section and can be proposed as an alternative to opioids postoperatively.…”
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Effect of Intranasal Calcitonin in a Patient with McCune-Albright Syndrome, Fibrous Dysplasia, and Refractory Bone Pain by Tayane Muniz Fighera, Poli Mara Spritzer

“…She was diagnosed with MAS at 4 years of age and, during follow-up, she had multiple pathological fractures and bone pain refractory to treatment with bisphosphonates, tricyclic antidepressants, and opioids. The pain was incapacitating and the patient required a wheelchair. …”
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Quo Vadis PCA? A Review on Current Concepts, Economic Considerations, Patient-Related Aspects, and Future Development with respect to Patient-Controlled Analgesia by S. Nardi-Hiebl, L. H. J. Eberhart, M. Gehling, T. Koch, T. Schlesinger, P. Kranke

“…Pharmaceutical research focuses on the reduction or avoidance of opioids, side effects, and adverse events although influence of these aspects appears to be minor. …”
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Pregabalin Prescription for Neuropathic Pain and Fibromyalgia: A Descriptive Study Using Administrative Database in Japan by Mikito Hirakata, Satomi Yoshida, Sachiko Tanaka-Mizuno, Aki Kuwauchi, Koji Kawakami

“…The duration of the prescription period was 111.9 (mean) and 53 (median) days, and the frequently coprescribed analgesics included NSAIDs, opioids, and Neurotropin®. About one half of the patients had spinal disorders. …”
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Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado by Kelli Jo Welter, Mackenzie N. DeVine, Sharon E. Gordon, Gina Demasellis

“…Pain and agitation may be refractory to opioids and alpha-2 agonists, prompting the use of adjunctive analgesics and sedatives with alternative mechanisms. …”
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Novel sequential proximal iliopsoas compartment block: A four-in-one block as a primary anaesthetic technique for intramedullary femoral nailing surgery: A retrospective study by Carlos Rodrigues Almeida

“…No tachycardia or hypertensive events were noted. No additional opioids were given. No statistically different values were observed when the pre-incisional and intraoperative mean arterial pressure values were compared (P = 0.52), and the preoperative NPRS compared with the NPRS at 24 h showed a statistically significant difference (P < 0.001). …”
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Technical aspects of neuraxial analgesia during labor and maternity care: an updated overview by Antonio Coviello, Carmine Iacovazzo, Maria Grazia Frigo, Marilena Ianniello, Dario Cirillo, Giuseppe Tierno, Andrea Uriel de Siena, Pasquale Buonanno, Giuseppe Servillo

“…The following pharmacological and non-pharmacological approaches were assessed: spinal techniques, such as epidural analgesia (EA), combined spinal-epidural (CSE), dural puncture epidural (DPE), and continuous spinal anesthesia (CSA); pharmacological administration of nitrous oxide (N2O) and systemic opioids (morphine, fentanyl, and pethidine); as the third one transcutaneous electric nerve stimulation (TENS), acupressure/acupuncture, aromatherapy, and breathing exercises. …”
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The combined impacts of toxic drug use and the 2021 Heat Dome in Canada: A thematic analysis of online news media articles. by Emily J Tetzlaff, Nicholas Goulet, Melissa Gorman, Glen P Kenny

“…Simultaneously, toxic drug use and overdoses related to high-risk use of opioids and polysubstance use continued to rise across the country. …”
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Reduction in Healthcare Resource Utilization Following Treatment With a Home-Based Footworn Device in Patients With Knee Osteoarthritis: A Retrospective Claims Analysis by Josh Mark, Shirley Shema-Shiratzky, Joel Sommer, Tim Nolan, Ganit Segal

“…**Results:** HCRU decreased after utilizing the new intervention including a decrease of 79% in diagnostic claims, a 70% decrease in outpatient services, a 22% decrease in non-operative treatments, a 61% decrease in pain medications including an 85% drop in opioids use, and a 44% decrease in intra-articular injections. …”
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Patterns of pregabalin prescribing in four German federal states: analysis of routine data to investigate potential misuse of pregabalin by Ronja Flemming

“…Of the patients misusing pregabalin, 365 (42%) had a diagnosed history of substance use disorders and 359 (41%) had been prescribed another drug with addictive potential (opioids) before. The prescribers of those patients potentially misusing pregabalin were more loosely connected within networks compared with prescribers of patients prescribed pregabalin as recommended.Conclusion This study found that patients could exceed recommended doses of pregabalin by getting prescriptions from multiple physicians. …”
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Restless Legs Syndrome: A Comprehensive Review of Current Treatment Methods and the Disease's Impact on Quality of Life by Natalie Papachristoforou, Natalia Tekiela, Daria Michałka, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Emilia Bąk, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

“…Pharmacological strategies involve dopaminergic medications, low-potency opioids, and benzodiazepines, with a target on minimizing side effects and dependency. …”
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Fall risk-increasing drugs and associated health outcomes among community-dwelling older patients: A cross-sectional study in Croatian cohort of the EuroAgeism H2020 project by Paar Elizabeta, De Lai Eleonora, Držaić Margita, Kummer Ingrid, Bužančić Iva, Hadžiabdić Maja Ortner, Brkic Jovana, Fialová Daniela

“…The most common drug classes were diuretics, benzodiazepines, and opioids (in 51.1 %, 38.1 %, and 17.2 % participants, respectively). …”
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Patient Complications after Interscalene Block: A Retrospective Comparison of Liposomal Bupivacaine to Nonliposomal Bupivacaine by Jacob L. Hutchins, Jason Habeck, Zac Novaczyk, Richard Campbell, Christopher Creedon, Ellen Spartz, Michael Richter, Jeremy Wolter, Gaurav Suryawanshi, Alexander Kaizer, Aaron A. Berg

“…Medical records were individually reviewed for surgical procedure, block medications, complications related to the block or surgical procedure, phone calls to the healthcare system for issues related to opioids or pain within 3 and within 30 days, readmissions within 30 days, and emergency room visits for complications within 3 and 30 days. …”
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Sensitivity of Self-reported Opium Use in Cancer Patients: Implications for conducting epidemiological studies by Vahideh Mohseni, Maryam Hadji, Mina Khaki, Omid Nabavian, Kazem Zendehdel, Hamideh Rashidian

“…In this study, we avoided using urine tests as the gold standard to prevent false positive results, given that most cancer patients use opioids to alleviate their pain. Instead, we relied on their reports of use to anesthesiologists as the gold standard and compared it with their reports to interviewers to calculate sensitivity Results: The sensitivity of self-reported opium use among cancer patients was approximately 63.33% (95% CI: 43.86% – 80.07%). …”
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A Multimodal Approach to Analgesia in Anorectal Surgery by T. N. Garmanova, D. R. Markaryan, E. A. Kazachenko, A. M. Lukianov, M. A. Kazachenko, M. A. Agapov

“…Acetaminophen combined with other systemic analgesics is advisable for patients with severe pain. The opioids use is justified only for moderate-severe postoperative pain. …”
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Delayed Acetaminophen Absorption Resulting in Acute Liver Failure by Huiling Tan, Paul Stathakis, Benoj Varghese, Nicholas A. Buckley, Angela L. Chiew

“…The metabolite data demonstrated increasing CYP metabolites in occurrence with the delayed acetaminophen peak concentration. Discussion. Opioids and antimuscarinic agents are known to delay gastric emptying and clonidine may also have contributed. …”
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Ultrasound-Guided Rhomboid Block versus Paravertebral Block in Postoperative Analgesia for Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Clinical Trial by Yan Wang, Xiaoping Gu, Simin Huang, Minke Shi, Xiaofeng He, Zhengliang Ma

“…The visual analogue scale (VAS) scores at rest and cough during 48 h postoperatively and the postoperative consumption of pain rescue were the primary outcomes, and the QoR15 score 48 h postoperatively, the usage of opioids during and after operation, and nerve block-related complications were the secondary outcomes. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…We now propose a “zero-tolerance” antiemetic algorithm for outpatients that involves routine prophylaxis by first avoiding volatile agents and opioids to the extent possible, using locoregional anesthesia, multimodal analgesia, and low doses of three nonsedating off-patent antiemetics. …”
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Bibliometric and visual analysis in the field of electroacupuncture’s analgesia and regulation on negative emotion from 2014 to 2024 by Xubo Huang, Jiajie Gao, Yuxin Ding, Jiali Wang, Junfan Fang, Junfan Fang, Jianqiao Fang, Jianqiao Fang, Junying Du, Junying Du

“…Major research themes include the modulation of neurotransmitter systems, the role of endogenous opioids, and the impact of EA on chronic pain and mood disorders. …”
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