Comparison of Real-world Outcomes Between Patients Treated with Tapentadol ER or Oxycodone CR by Mike Durkin, Jacqueline Pesa, Jessica Lopatto, Rachel Halpern, Damon Van Voorhis, Stephanie Korrer

“…**Background:** The objective of this study was to compare health care utilization and costs between matched cohorts of chronic pain patients treated with the opioids tapentadol extended release (ER) or oxycodone controlled release (CR). …”
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A Systematic Review of Postoperative Pain Outcome Measurements Utilised in Regional Anesthesia Randomized Controlled Trials by E. Pushpanathan, T. Setty, B. Carvalho, P. Sultan

“…The most commonly (16/31) used outcome measures were verbal numerical grading of pain out of 10, total opioid consumption, and visual analogue scale 10 cm (VAS). …”
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Efficacy and safety of a generic remifentanil formulation versus fentanyl and Ultiva during general anaesthesia: A phase III, prospective, multi-centric, observer-blind, randomised... by Indrani Hemantkumar, Ashok Kumar Swain, Manjaree Mishra, Swati Singh, Challakere Lakshminarain Gurudatt, Janampet Bekkam Giridhar

“…Background and Aims: Remifentanil and fentanyl are potent opioid analgesics commonly used during surgery due to their distinct pharmacological profiles. …”
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Pharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy by Mita Banerjee, Thomas Efferth

“…In this context, we discuss aspects related to traditional herbal medicine, fair access and benefit sharing of indigenous knowledge about medicinal plants, post-traumatic stress syndrome, the opioid crisis, stress myocardiopathy (broken heart syndrome), and global environmental pollution with microplastics. …”
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Pain Management of Pediatric Musculoskeletal Injury in the Emergency Department: A Systematic Review by Sylvie Le May, Samina Ali, Christelle Khadra, Amy L. Drendel, Evelyne D. Trottier, Serge Gouin, Naveen Poonai

“…Larger trials are required for further evaluation of analgesics, especially trials combining a nonopioid with an opioid agent or with a nonpharmacological intervention.…”
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Protocol for a scoping review study on the prevalence and public health consequences of non-medical use (NMU) of tramadol in Africa. by Saidou Sabi Boun, Olumuyiwa Omonaiye, Sanni Yaya, Sanni Yaya

“…<h4>Background</h4>Tramadol is one of the most prescribed painkillers in the world. It is a synthetic opioid that is an excellent alternative to morphine and its derivatives in African countries. …”
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Analgesic Impact of a Popliteal Plexus Block to Standard Adductor Canal Block in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Blind Clinical Trial by Atef Mahmoud, Maged Boules, Joseph Botros, Mohamed Mostafa, Safaa Ragab, Mohammed Alsaeid

“…The addition of PPB to ACB was associated with improved analgesia and a reduced need for opioid-based sedatives following ACLR with an ipsilateral hamstring graft (https://clinicaltrials.gov/ct2/show/NCT04020133).…”
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Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats by Sheng-Lung Hsu, Hsien-Hui Chung, I-Hung Chen, Yat-Ching Tong

“…Western blotting analyses were performed for prostate μ-opioid receptors (MOR) and ATP-sensitive potassium (KATP) channel proteins: sulfonylurea receptor (SUR) and inwardly rectifying potassium channel (Kir) 6.2 subunits. …”
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Understanding the dynamics of post-surgical recovery and its predictors in resource-limited settings: a prospective cohort study by Awoke Fetahi Woudneh

“…Results Significant predictors of prolonged recovery time included higher BMI, longer surgery duration, the presence of diabetes and hypertension, higher ASA scores, and major post-operative complications. Opioid pain management was associated with increased recovery time, while inpatient physiotherapy reduced recovery duration. …”
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Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology by V. T. Ivashkin, Yu. A. Shelygin, Ye. K. Baranskaya, Ye. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. O. Golovenko, O. V. Golovenko, Ye. G. Grigoryev, N. V. Kostenko, T. L. Lapina, I. D. Loranskaya, O. S. Lyashenko, I. V. Mayev, Ye. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, A. S. Trukhmanov, O. Yu. Fomenko, I. L. Khalif, E. Yu. Chashkova, A. A. Sheptulin, O. S. Shifrin, V. V. Yanovoy

“…Enterokinetic agent prucalopride may be prescribed at inefficacy of laxatives. Peripheral opioid agonists (trimebutine maleate) normalizing intestinal motor activity via action on different subtypes of peripheral opioid receptors, combined plant-derived medication STW 5 are applied as well. …”
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Drug-Induced Myoclonus: A Systematic Review by Jamir Pitton Rissardo, Ana Letícia Fornari Caprara, Nidhi Bhal, Rishikulya Repudi, Lea Zlatin, Ian M. Walker

“…The subclasses of medications with level A evidence were intravenous anesthetics (etomidate), cephalosporins (ceftazidime, cefepime), fluoroquinolones (ciprofloxacin), selective serotonin reuptake inhibitors (citalopram, escitalopram, paroxetine, sertraline), tricyclic antidepressant (amitriptyline), glutamate antagonist (amantadine), atypical antipsychotics (clozapine, quetiapine), antiseizure medications (carbamazepine, oxcarbazepine, phenytoin, gabapentin, pregabalin, valproate), pure opioid agonist (fentanyl, morphine), bismuth salts, and mood stabilizers (lithium). …”
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Sublingual Sufentanil vs. Intravenous Fentanyl for the Treatment of Acute Postoperative Pain in the Ambulatory Surgery Center: A Randomized Clinical Trial by Aaron Berg, Jason Habeck, Michael Strigenz, Jonah Pearson, Alexander Kaizer, Jacob Hutchins

“…Sublingual sufentanil is a novel opioid medication to treat moderate to severe pain postoperatively. …”
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Role of adductor canal block and genicular nerve block on postoperative pain and enhanced recovery in patients undergoing total knee arthroplasty: A randomized clinical trial by Bassel Mohammed Elfokery, Mustafa Seet, Tareef Ashour, Hatem Alharbi, Mujeeb Ashraf, Hatim Alshareef, Mohammad Nyaz, Rayan Bakhreba, Atif Sait

“…Conclusions: The combination of ACB and GNB provided adequate analgesia and enhanced recovery via reducing pain scores, total opioid consumption with shorter hospital stays, better mobility, and patient satisfaction.…”
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Hepatitis C Prevalence on the Rise but Screening at Safety Net Institutions Lagging behind by Jarin Prasa, Syed S. Karim, Bobby Jacob, Paul Mustacchia

“…Despite effective antiviral medications, acute infections have increased in recent years, likely due to IV drug use and the opioid epidemic. Previous guidelines recommended one-time screening for individuals born between 1945 and 1965. …”
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Functional constipation by Yu. O. Shulpekova, A. A. Kurbatova, A. V. Sedova

“…In the section devoted to the bowel diseases the new entity - opioid-induced constipation was defined; besides that diagnostic (mostly - the time-based criteria) of irritable bowel syndrome and functional constipation were modified. …”
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Transcutaneous Electrical Nerve Stimulation Integrated into Pants for the Relief of Postoperative Pain in Hip Surgery Patients: A Randomized Trial by Yohann Opolka, Courage Sundberg, Robin Juthberg, Amelie Olesen, Li Guo, Nils-Krister Persson, Paul W. Ackermann

“…Moreover, patients in the active TENS group were more likely able to perform a 3-meter walk test by the end of the intervention (p=0.04). Analysis of the opioid-sparing effect of TENS was inconclusive (p=0.066). …”
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Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients by Antonio Abramo, Claudio Di Salvo, Francesca Foltran, Francesco Forfori, Marco Anselmino, Francesco Giunta

“…Xenon anesthesia improved PaO2/FiO2 ratio and maintained its distinctive rapid recovery times and cardiovascular stability. A reduction of opioid consumption during and after surgery and an increased incidence of PONV were also observed in xenon group.…”
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Comparison of analgesic efficacy of ultrasound-guided external oblique intercostal plane block and subcostal transversus abdominis plane block in patients undergoing upper abdomina... by Shruti Shrey, Chandni Sinha, Abhyuday Kumar, Ajeet Kumar, Amarjeet Kumar, Sreehari Nambiar

“…Secondary outcomes were 24-hour opioid consumption, pain scores (at 30 minutes and at 1, 2, 4, 6, 12, and 24 hours), patient satisfaction scores (48 hours), and block-related complications. …”
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Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects by Choi SH, Kim YM, Son JY, Ahn DK

“…The inhibitory effects of dynorphin were blocked by nor-binaltorphimine, a kappa receptor antagonist, whereas the facilitatory effects were inhibited by D,L-2-amino-5-phosphonovaleric acid, an NMDA receptor antagonist.Conclusion: These findings suggest that dynorphin A-induced excitatory responses are mediated by NMDA receptors, whereas its inhibitory responses are mediated through kappa opioid receptors in dental pain. Thus, dynorphin exerts diverse effects, highlighting its role in the perception and modulation of dental pain.Keywords: dynorphin, N-methyl-D-aspartate, kappa receptor, dental pulp, analgesics…”
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Continuous Erector Spinae Plane Block for Analgesia after Thoracotomy for Lung Transplantation in an Anticoagulated Patient by Mark Mudarth, Veena Satyapriya, John Coffman, Peter DeSocio, Alec Lawrence, Shana Schwartz, Michael Kushelev

“…Lung transplant recipients are at particular high risk for postoperative respiratory failure as a result of poorly controlled pain, inadequate graft expansion, decreased cough, and reliance on systemic opioid therapy. Thoracic epidural and paravertebral blocks have been employed with the goal of improving postoperative pain control, improving pulmonary mechanics, and limiting the need for narcotic administration. …”
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