The chronic need to improve the management of pain by Eldon Tunks

“…When asked what obstacle hindered their use of strong opioid analgesics, an unexplained 10% of palliative care doctors and 14% of primary care doctors answered "nothing in particular".…”
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Superficial Dorsal Vein Thrombosis of the Penis and Pulmonary Embolism in a 15-year-old Boy: A Case Report by Tomas Leng, Jason H. Homme, Jana Anderson

“…After the administration of opioid analgesics, he developed hypoxia prompting an urgent computed tomography pulmonary angiogram that revealed bilateral segmental acute pulmonary embolism (PE). …”
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The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis by Guilin Zhang, Guixing Xu, Yao Tang, Lingxue Zhang, Xi Chen, Xingyu Liang, Ling Zhao, Dehua Li

“…Conclusions: The summary estimates indicate that auriculotherapy may be beneficial in reducing APP and opioid consumption in specific surgeries based on low-to-moderate quality evidence. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…In the setting of an ongoing opioid crisis where 3 deaths/day are recorded in the neighborhood where the study population resides, we documented 4 deaths. …”
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Using photovoice to define “community” in substance use disorder research engaging service users, providers, and policymakers by McGladrey Margaret L, Marisa Booty, Ramona Olvera, Peter Balvanz, Hilary L. Surratt, Shannon Matthews, Susannah Stitzer, Owusua Yamoah, Sylvia Ellison, Kevin Campbell, Amy Farmer, Bethany Gealy, Mike Greenwell, Felicia Harris, Amy Kuntz, Sara Szelagowski, Alexandrea Shouse, Carrie B. Oser

“…., SUD service providers, service users, and the public) in the context of a large-scale community-engaged opioid overdose reduction intervention. A team of 14 participants and researchers used an adapted thematic analysis method to interpret Photovoice data from 65 total participants in Kentucky, Massachusetts, and Ohio. …”
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Analgesia in pediatric abdominal surgery by Jan Geudens, An Teunkens

“…We conducted a literature review in which relevant articles, which focused on the efficacy, side effects, and locoregional techniques of pharmacological products, were included and analyzed.The combined use of classic analgesics (such as paracetamol and nonsteroidal anti-inflammatory drugs) or alpha-2 agonists together with opioids can ensure lower opioid use, which in turn reduces the risk of adverse effects. …”
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Pulsed Electromagnetic Field Therapy as a Complementary Alternative for Chronic Pelvic Pain Management in an Interstitial Cystitis/Bladder Pain Syndrome Patient by Tyler L. Overholt, Christina Ross, Robert J. Evans, Stephen J. Walker

“…Current management can be aggressive for individuals who are refractory to less invasive options, often resulting in the use of opioid narcotics and/or surgical procedures under general anesthesia, with higher risks and side effects to patients. …”
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Anaphylactic shock induced by intravenous ketorolac: A case report by Huijuan Lu, Kaili Lai, Shuzhu Lin, Guining Dang

“…Ketorolac trometamol injection is the first injectable nonsteroidal anti-inflammatory drug (NSAID) approved for the short-term management of moderate to severe pain. As a non-opioid alternative, it represents a critical development for acute pain relief, particularly in postoperative and injury-related scenarios. …”
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Subcutaneous Extended-Release Buprenorphine Use in Pregnancy by Craig V. Towers, Heather Deisher

“…Background. Opioid use disorder (OUD) in pregnancy is managed by medication-assisted treatment. …”
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Fatal Overdose due to Confusion of an Transdermal Fentanyl Delivery System by Ingo Voigt

“…A 58-year-old patient presenting with clinical signs of opioid poisoning (hypoventilation, bradycardia, hypotension, and miosis) was admitted to our ICU. …”
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Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. …”
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Substance Abuse: A Public Health Concern by Ulfat Amin, Adil Mudasir Malla, Ishrat Amin, Roohi Jan

“…Cannabis, sedatives, hypnotics, anxiolytics, inhalants, opioids, hallucinogens, and stimulants are the most abused drugs. …”
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Management of an Oral Ingestion of Transdermal Fentanyl Patches: A Case Report and Literature Review by Andrew C. Faust, Ralph Terpolilli, Darrel W. Hughes

“…Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. …”
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Dynamics of Acute Postsurgical Pain over the Last Decade: A Bibliometric Analysis by Zhimin Tan, Yanjie Dong, Qian Li

“…Future research is likely to concentrate on the use of opioids and technological innovations in regional anesthesia. …”
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A septo-hypothalamic-medullary circuit directs stress-induced analgesia by Devanshi Piyush Shah, Pallavi Raj Sharma, Rachit Agarwal, Arnab Barik

“…Furthermore, our results reveal that the dLS→LHA pathway is opioid-dependent and modulates pain through the pro-nociceptive neurons in the rostral ventromedial medulla (RVM). …”
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Bioactive peptides and antinutrients in chickpea: description and properties (a review) by M. Ahangaran, D. A. Afanasev, I. M. Chernukha, N. G. Mashentseva, M. Gharaviri

“…Bioactive peptides of chickpea seeds have antioxidant, ACE-inhibiting, cholesterollowering, antihypertensive, antimicrobial, antithrombotic, immunomodulatory, and opioid activities as well as the ability to bind minerals. …”
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Determination of remifentanil in neonatal dried blood spots by liquid chromatography-tandem mass spectrometry by Trontelj Jurij, Rozman Aleš, Mrhar Aleš

“…Remifentanil is an ultra-short-acting synthetic opioid-class analgesic which might be increasingly used “off-label” as pain management during labour. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…In this study, we used mice lacking the µ-opioid receptor gene (Oprm1−/−), which has been shown to have deficits in social competence and communication, to assess the hypothesis that early enrichment can ameliorate sociability during development and adulthood. …”
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Combination Olanzapine and Samidorphan for the Management of Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review by Hannah W. Haddad, Elena Boardman, Brooke Williams, Rama Mouhaffel, Adam M. Kaye, Alan D. Kaye

“…Samidorphan mitigates the weight gain side effects of olanzapine by antagonizing μ-, κ-, and δ-opioid receptors. The use of combination drugs to treat psychiatric conditions is an emerging field with the goal of increasing therapeutic efficacy and decreasing undesirable side effects. …”
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Morphine for the Treatment of Pain in Sickle Cell Disease by Mihir Gupta, Lilian Msambichaka, Samir K. Ballas, Kalpna Gupta

“…Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging. Opioids are the major family of analgesics that are commonly used for treating severe pain. …”
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