A Prospective Cohort Study Evaluating the Ability of Anticipated Pain, Perceived Analgesic Needs, and Psychological Traits to Predict Pain and Analgesic Usage following Cesarean De... by Brendan Carvalho, Ming Zheng, Scott Harter, Pervez Sultan

“…Postoperative outcome measures included post-CD pain (combined rest and movement) and opioid used for the 48-hour study period. Results. …”
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Ketamine Infusion for Sedation and Analgesia during Mechanical Ventilation in the ICU: A Multicenter Evaluation by Kathryn M. Pendleton, Laurel E. Stephenson, Nick Goeden, Anna R. Benson, Qi Wang, Salman B. Mahmood, Kelly A. Considine, Matthew E. Prekker

“…We captured data including ketamine indication, dose, unintended effects, and adjustments to coadministered sedatives or opioids. We analyzed these data to determine the incidence of reported unintended effects of ketamine infusion (primary outcome) and changes in exposure to coadministered sedatives or opioids during ketamine use (secondary outcome). …”
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Perioperative Management of a Patient Taking Suboxone® at the Time of Ambulatory Surgery by Shawn H. Malan, Christopher H. Bailey, Narjeet Khurmi

“…In 2016, more than 11 million people reported misuse of opioids in the previous year. In an effort to combat opioid use disorder (OUD), the use of agonist/antagonist is becoming increasingly common, with more than 2.2 million patients reporting use of a buprenorphine containing medication such as Suboxone®. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance. …”
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Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases by Dimitar G. Tonev, Silvia A. Lalova, Elena P. Petkova-Lungova, Nikolay V. Timenov, Gabriela M. Radeva, Todor G. Kundurzhiev

“…To date, there are no data on its prophylactic coanalgesic (opioid-sparing) effect after RT in patients with complicated bone metastases compared to uncomplicated ones, which is the aim of our study. …”
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Let us be heard: critical analysis and debate of collaborative research approaches used in implementation science research with equity-deserving populations by Sarah Madeline Gallant, Cynthia Mann, Britney Benoit, Megan Aston, Janet Curran, Christine Cassidy

“…Pregnant persons diagnosed with opioid use disorder (OUD) is an equity-deserving population that continues to experience stigmatization within our healthcare system. …”
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Effect of a multimodal analgesia strategy on remifentanil daily consumption in mechanically ventilated adult ICU patients: study protocol for a randomised, placebo-controlled, doub... by Thibault Mura, Jean-Yves Lefrant, Remy Widehem, Camille Nicolet, Violaine Delannoy, Laurie Barthelemi, Ian Soulairol, Claire Roger

“…International guidelines emphasise the importance and benefits of multimodal analgesia to minimise opioid consumption and its side effects. However, no recommendation about drugs or protocol has been formulated. …”
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Intermittent Boluses of Local Anesthetic Through Quadratus Lumborum Catheters for Analgesia in a Living Donor Hepatectomy by Shelly B. Borden, Molly K. Groose, Eric R. Simon, Aaron S. Hess, Kristopher M. Schroeder

“…Coagulopathy and various side effects often preclude the use of neuraxial regional techniques and opioids for postoperative analgesia in patients with large “J” incisions. …”
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Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…The altered CBF were derived by a voxel-wised two sample t-test compare and spatial correlated with serotonin, dopamine, γ-aminobutyric acid, opioid, noradrenaline, N-methyl-D-aspartic acid, acetylcholine and glutamate neurotransmitter density maps. …”
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Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury by Vladislav N. Karkischenko, Veronika I. Skvortsova, Melik T. Gasanov, Yuriy V. Fokin, Maxim S. Nesterov, Nataliya V. Petrova, Oxana V. Alimkina, Igor A. Pomytkin

“…Leytragin’s effects are mediated by opioid receptors, since naloxone, an antagonist of opioid receptors, abrogates the leytragin effect on SIRT1 expression. …”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…In our study, we hypothesize that a low-dose perioperative ketamine infusion will reduce opioid consumption and improve analgesia when compared to standard therapy. …”
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Barriers to dental providers’ use of a clinical decision support tool for pain management following tooth extractions by Shannon Gwin Mitchell, Jan Gryczynski, Donald C. Worley, Stephen E. Asche, Anjali R. Truitt, D. Brad Rindal

“…Background De-implementing non-effective or even harmful practices in healthcare is sometimes necessary, as has been the case with opioid prescribing in dentistry over the past decade. …”
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Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries by Syed Najeebullah Khadri, R Shankar Anand, K Soundarya Priyadharsini, T. Krishna Prasad

“…Paracetamol and ketorolac are effective in blunting postoperative pain scores and opioid consumption, but their comparison, when used preemptively, has been less studied. …”
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Randomized Controlled Trial of Laparoscopic versus Open Radical Cystectomy in a Laparoscopic Naïve Center by Waleed Mohamed Fadlalla, Ayman Hanafy, Mahmoud Abdelhakim, Hatem Aboulkassem, El Sayed Ashraf, Ahmed Abdelbary

“…The trial was designed to compare both approaches regarding operative time, blood loss, transfusion requirements, length of hospital stay, time to oral intake, requirement of opioid analgesia, and complications. Results. LRC was associated with less hospital stay (9.8 vs. 13.8 days, P=0.001), less time to oral solid intake (6 vs. 8.6 days, P=0.031), and lower opioid requirements (23.3% vs. 53.3%, P=0.033). …”
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Clinical Benefits of Parasternal Block with Multihole Catheters when Inserted before Sternotomy by Vedat Eljezi, Crispin Jallas, Bruno Pereira, Melanie Chasteloux, Christian Dualé, Lionel Camilleri

“…Background: The aim of this study was to assess whether parasternal block with multihole catheters inserted before surgical incision enables to alleviate postoperative analgesia and opioid reduction in cardiac surgery patients with sternotomy. …”
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Continuous Infusion of Ketamine in Mechanically Ventilated Patients with SARS-CoV-2 by Brian Phan, Afua Agyemang, Walter Klein, Suman B. Thapamagar

“…Nevertheless, the use of ketamine was associated with higher MAP, reductions in CRP in select timepoints, and overall lower opioid requirements.…”
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Relative perioperative analgesic efficacy of single-shot serratus anterior plane block versus thoracic paravertebral block in breast and thoracic surgeries – A systematic review an... by Jeetinder K. Makkar, Narinder P. Singh, Bisman Jeet Kaur Khurana, Preet M. Singh

“…The primary objective was the time to first rescue analgesia, and the secondary objective encompassed opioid consumption within 24 h, pain scores at different time intervals, opioid-related adverse effects and block-related complications. …”
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Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives by Jagienka Agata Włodyka, Urszula Zelik, Maria Przygoda, Wiktoria Domino, Gabriela Trestka, Sabina Adamczyk, Kamila Stępień, Joanna Śnieżna, Wojciech Florczak, Karol Dzwonnik, Jakub Dziewic

“…Description of the state knowledge: Topics discussed include pathomechanisms of pruritus in pancreatic cancer include cholestatic, opioid-induced, paraneoplastic, neuropathic and pruritus caused by antineoplastic therapies. …”
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions by Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano

“…Objective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells. …”
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On-site quantitative detection of fentanyl in heroin by machine learning-enabled SERS on super absorbing metasurfaces by Yingkun Zhu, Haomin Song, Ruiying Liu, Yunyun Mu, Murali Gedda, Abdullah N. Alodhay, Lei Ying, Qiaoqiang Gan

“…Abstract The global surge in opioid misuse, particularly fentanyl, presents a formidable public health challenge, highlighted by increasing drug-related mortalities. …”
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