Biparatopic antibodies: therapeutic applications and prospects by David L. Niquille, Kyle M. Fitzgerald, Nimish Gera

“…This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious diseases. Biparatopic binding can lead to superior affinity and specificity, promote antagonism, lock target conformation, and result in higher-order target clustering. …”
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Earlier Diagnosis of Progressive Disease during Bevacizumab Treatment Using O-(2-F-Fluorethyl)-L-Tyrosine Positron Emission Tomography in Comparison with Magnetic Resonance Imaging by Norbert Galldiks, Marion Rapp, Gabriele Stoffels, Veronika Dunkl, Michael Sabel, Karl-Josef Langen

“…Newly defined criteria for treatment assessment and diagnosis of tumor progression (ie, RANO [Response Assessment in Neuro-Oncology] criteria) have implemented signal alterations on T 2 /fluid-attenuated inversion recovery (FLAIR) sequences to changes in contrast enhancement. …”
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Sarcopenia as a leading component of malignant cachexia syndrome by V. K. Lyadov, E. A. Bulanova, A. P. Seryakov

“…Its investigation is perspective trend in clinical studies in oncology.…”
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Assessment of resident doctors’ knowledge levels regarding radiation doses during routine radiological investigations by Selin Doğan Jamil, Amirreza Teymourfamian Asl, Badiozzaman Hosseinpour, Nimet Emel Lüleci

“…Among 235 (resident doctors surveyed, radiology, and related specialty (nuclear medicine and radiation oncology) residents demonstrated superior accuracy in estimating radiation doses for various radiological tests compared to their counterparts in other departments. …”
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R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia by Alay Mansurov, Eric Christenson

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Ipilimumab: A First-in-Class  T-Cell Potentiator for Metastatic Melanoma by Bartosz Chmielowski

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Long-Term Remission of a Spinal Atypical Teratoid Rhabdoid Tumor in Response to Intensive Multimodal Therapy by Fahd Refai, Haneen Al-Maghrabi, Hassan Al Trabolsi, Jaudah Al-Maghrabi

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Schwannoma Localized Retroperitoneally in a 14-Year-Old Boy by Hasan Cayirli, Halil Ibrahim Tanriverdi, Ali Aykan Ozguven, Cuneyt Gunsar, Betul Ersoy, Ali Riza Kandiloglu

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Anti-cancer immunotherapy-related cardiotoxicity: preventable and treatable by Wu Helena T., Hsu Vanessa, Win Shwe, Xing Yan

“…Anti-cancer immunotherapies, particularly immune checkpoint inhibitors, have significantly advanced oncology treatments but are associated with rare, potentially severe cardiotoxicities. …”
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A Rare Case Report: A Malignant Histiocytic Tumor in the Form of Ovarian Mass by Emsal Pinar Topdagi Yilmaz, Yakup Kumtepe, Yunus Emre Topdagi, Seray Kaya Topdagi

“…Our patient was then treated systemically by medical oncology. In conclusion, the rare malignancy group was investigated in the present study along with an evaluation of the current literature.…”
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New hope for the world cancer day by Gerry Melino, Julia Bischof, Wen-Lian Chen, Wei Jia, Harmut Juhl, Gelina S Kopeina, Alessandro Mauriello, Flavia Novelli, Manuel Scimeca, Yufang Shi, Brunella Maria Pirozzi, Giuseppe Sica, Alexey V. Zamaraev, Boris Zhivotovsky

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New developments in immunotherapy for SCLC by Zhonglin Hao, Tsering Dolkar, Christopher Gates, Reinhold Munker

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Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? by Diógenes Alayón-Laguer, Melissa Alsina, Jose L. Ochoa-Bayona, Ernesto Ayala

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Implementing the practice of early skin-to-skin contact among infants ≥35 weeks gestation born vaginally: a quality improvement study by Kuldeep Singh, Arun Singh, Nisha Toteja, Pratibha Singh, Rohit Sasidharan, Neeraj Gupta, Bharti Yadav, Naveen Kumar Bhardwaj, KL Prasanna, Birkha Bishnoi

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State of Oral Mucosa as an Additional Symptom in the Course of Primary Amyloidosis and Multiple Myeloma Disease by Maciej R. Czerniuk, Artur Jurczyszyn, Grzegorz Charlinski

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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

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Establishment and evaluation of nomogram model for risk of PICC related upper extremity deep vein thrombosis in elderly patients (高龄患者PICC导管相关性上肢深静脉血栓发生风险的列线图模型构建与评估)... by YAN Ying (闫影), QI Xiaojiu (齐晓玖), SU Qian (苏倩), WANG Pei (王培)

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Properties of new polycationic bacteriochlorin photosensitizers: cytotoxicity and interaction with biofilms by Irina Tiganova, Yulia Zhizhimova, Eteri Tolordava, Elena Makarova, Natalia Shevlyagina, Alexander Barmashov, Maria Baryshnikova, Vladimir Zhukhovitsky, Yulia Romanova

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