Cutaneous metastases of invasive lobular breast cancer as the first clinical manifestation: a case report by Saja Karaja, Ahmad Almohamed, Ayham Qatza, Ahmed Aldolly, Sanaa Mansour, Alae Aldin Almasri

“…Cutaneous metastasis (CM) is a rare phenomenon, occurring in only 0.6% to 10.4% of oncology patients. Breast carcinoma represents nearly one-third of all CM cases, although it manifests in a minority of patients with breast cancer (BC). …”
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Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction by Joselle Cook, Steven Song, Anthony Ventimiglia, Carol Luhrs

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Malignant Peripheral Nerve Sheath Tumor of the Inguinum and Angiosarcoma of the Scalp in a Child with Neurofibromatosis Type 1 by Marija Milković Periša, Tihana Džombeta, Jasminka Stepan Giljević, Božo Krušlin

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Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space by Maria Moreno-Villanueva, Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu

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Prolyl 4‐hydroxylase α‐subunit family regulation of type I collagen deposition and IL17RB/c‐Jun activation synergistically mediate choline dehydrogenase promotion of colorectal can... by Xiaowen Yang, Yifei Li, Xinzhuang Shen, Shuying Wang, Zhuqing Zhang, Wenfei Du, Chenglong Yang, Xinyu Jiang, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen

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The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer by Mustafa Kandaz, Atalay Balsak, Hatice Bengü Çobanoğlu

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High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients by Annabella Di Mauro, Mariachiara Santorsola, Giovanni Savarese, Roberto Sirica, Monica Ianniello, Alessia Maria Cossu, Anna Ceccarelli, Francesco Sabbatino, Marco Bocchetti, Anna Chiara Carratù, Francesca Pentimalli, Gerardo Ferrara, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano

“…Comprehensive clinical and molecular profiling was conducted, including next-generation sequencing (NGS) for TMB evaluation with the TruSight Oncology® kit. Overall survival (OS) was the primary endpoint. …”
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Safety of interleukin inhibitors in patients with plaque psoriasis and history of neoplasms: a multicenter retrospective study – IL PSO (Italian landscape psoriasis) by Mario Valenti, Luciano Ibba, Sara Di Giulio, Luigi Gargiulo, Piergiorgio Malagoli, Anna Balato, Carlo G. Carrera, Paolo Dapavo, Eugenia V. Di Brizzi, Valentina Dini, Francesca Gaiani, Francesco Loconsole, Angelo V. Marzano, Matteo Megna, Alessandra Michelucci, Luca Potestio, Simone Ribero, Antonio Costanzo, Alessandra Narcisi

“…However, their use in patients with a history of cancer is debated.Objective: We conducted a multicenter retrospective study across nine Italian Dermatology Units to assess the real-world effectiveness and safety of IL inhibitors (IL-23, IL-17, IL-12/23) in 136 oncological patients with moderate-to-severe plaque psoriasis. …”
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Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling by Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David T.W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

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Lenvatinib and tislelizumab versus atezolizumab and bevacizumab in combination with TAE-HAIC for unresectable hepatocellular carcinoma with high tumor burden: a multicenter retrosp... by Hongjie Cai, Song Chen, Shuangyan Tang, Yi Xiao, Feng Shi, Zhiqiang Wu, Ping Ma, Huanwei Chen, Wenquan Zhuang, Wenbo Guo

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Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Conclusion: A community-based oncology patient cohort was rapidly enrolled, creating a real-world clinico-genomic dataset. …”
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HPV16 <em>E6</em> Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway by Georgios Konstantopoulos, Danai Leventakou, Despoina-Rozi Saltiel, Efthalia Zervoudi, Eirini Logotheti, Spyros Pettas, Korina Karagianni, Angeliki Daiou, Konstantinos E. Hatzistergos, Dimitra Dafou, Minas Arsenakis, Amanda Psyrri, Christine Kottaridi

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Marital Status and Survival in Patients Diagnosed with Melanoma by J. A. Maas, A. J. Monreal, E. L. Diaz, G. Castro, P. Rodriguez de la Vega, M. Varella

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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

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Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma by Juan Li, Xuyu Gu, Chanchan Gao, Jun Zhang

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PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

“…Zhaoqian He,1– 3,&ast; Hua Chen,1– 3,&ast; Chen Liang,1– 3,&ast; Xiang Tang,1– 3 Lingmin Jiang,1– 3 Feihu Xie,1– 3 Qi Liu,1– 3 Yun Zheng1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yun Zheng; Qi Liu, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People’s Republic of China, Email zhengyun@sysucc.org.cn; liuqi9@sysucc.org.cnPurpose: To compare the clinical outcomes of different systemic therapies, specifically PD(L)1 inhibitors plus Lenvatinib versus Atezolizumab plus Bevacizumab, when combined with hepatic arterial infusion chemotherapy (HAIC) based on the FOLFOX regimen (oxaliplatin, fluorouracil, and leucovorin) as first line treatment for unresectable hepatocellular carcinoma.Patients and Methods: This real-world retrospective study enrolled 294 patients with unresectable HCC. …”
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Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

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Mammography Among Women Residing in Urban Versus Rural Utah: Breast Cancer Survival by Quinn Tanner, Chun‐Pin Chang, Karen Curtin, James VanDerslice, Lisa Gren, Vikrant Deshmukh, Michael Newman, Ankita Date, Mark Dodson, N. Lynn Henry, Mia Hashibe

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A Path to High-Value Gastric Cancer Surgery Care Delivery by Swee H. Teh, MD, Sharon Shiraga, MD, Aaron M. Kellem, BS (Math), Robert A. Li, MD, David M. Le, MD, Said P. Arsalane, MSHA, Fawzi S. Khayat, MD, Yan Li, MD, I-Yeh Gong, MD, Jessica M. Lee, MD

“…This comprehensive regional program, which encompasses regionalization care, laparoscopic approach, modern oncologic care, surgical subspecialization, and the MIREC pathway, can potentially improve gastric cancer surgery outcomes. …”
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Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice by Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska

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