A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal by Corry van den Bosch

“…Additionally, infection with Chikungunya Fever, a potentially oncogenic arbovirus, was associated with the onset of endemic Burkitt’s Lymphoma in one study and also with space-time case clusters of the lymphoma. …”
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Age Dependent Switching Role of Cyclin D1 in Breast Cancer by Carmela Rinaldi, Natalia Maria Malara, Rosalia D’Angelo, Antonina Sidoti, Attilio Leotta, Santo Lio, Basilio Caparello, Alessia Ruggeri, Vincenzo Mollace, Aldo Amato

“…Background: Cyclin D1 gene (CCND1) plays pivotal roles in the development of several human cancers, including breast cancer, functioning as an oncogene. The aim of this study was to better understand the molecular dynamics of ductal carcinomas with regard to proliferation and the ageing process.…”
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Fibroblast Growth Factor Receptor 3 (FGFR3)–Analyses of the S249C Mutation and Protein Expression in Primary Cervical Carcinomas by Haiyan Dai, Ruth Holm, Gunnar B. Kristensen, Vera M. Abeler, Anne‐Lise Børresen‐Dale, Åslaug Helland

“…This report weakens the hypothesis of FGFR3 as an oncogene of importance in cervical carcinomas.…”
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Cellular Senescence as a Target in Cancer Control by Mar Vergel, Juan J. Marin, Purificacion Estevez, Amancio Carnero

“…Recent findings suggest that cellular senescence is a natural mechanism to prevent undesired oncogenic stress in somatic cells that has been lost in malignant tumors. …”
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The Expression Regulation and Cancer-Promoting Roles of RACGAP1 by Jiacheng Lin, Yuhao Zhu, Zhaoping Lin, Jindong Yu, Xiaobing Lin, Weiyuan Lai, Beibei Tong, Liyan Xu, Enmin Li, Lin Long

“…This article mainly reviews the expression regulation of RACGAP1 and its cancer-promoting functions through oncogene expression mediation and Rho-GTPase activation.…”
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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…Nowadays, oncogene-directed therapy and immunotherapy represent the two most promising avenues for patients with metastatic melanoma. …”
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The Interaction of Src Kinase with β3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer by Stephan Huveneers, Erik H. J. Danen

“…Moreover, recent evidence from patient material and in vivo studies strongly indicate that this oncogenic signaling complex, consisting of c-Src and αvβ3, underlies tumor progression of human tumors. …”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Current evidence suggest that early growth response 1 (EGR1) plays a dual role as both an oncogene and a tumour suppressor in glioblastoma. Early growth response 1 expression is prevalent in glioblastoma, affecting over 80% of cases. …”
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Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets? by Athina Kladi-Skandali, Kleita Michaelidou, Andreas Scorilas, Konstantinos Mavridis

“…The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers. …”
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Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. Innovatively, the review synthesizes recent discoveries on the multifaceted roles of non-coding RNAs and cellular signaling pathways in modulating cell death within the context of EBV infection. …”
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Extragastrointestinal Stromal Tumor during Pregnacy by Ilay Gözükara, T. U. Kutlu Dilek, Hüseyin Durukan, Duygu Düsmez Apa, Suna Kabil Kucur, Saffet Dilek

“…Both of them most often express immunoreactivity for CD-117, a c-kit proto-oncogene protein. The coexistence of GIST and pregnancy is very rare, with only two cases reported in the literature. …”
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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. by Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger

“…Paradoxically, Rabex-5 is reported to be an oncogene in other cancers. We propose that Rabex-5 acts as a tumor suppressor via its E3 activity to inhibit Ras, Notch, and PI3K signaling and as an oncogene via its Rab5 GEF activity to enhance Ras and Notch signaling.…”
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p53 dosage can impede KrasG12D- and KrasQ61R-mediated tumorigenesis. by Özgün Le Roux, Jeffery I Everitt, Christopher M Counter

“…These results suggest that an extra copy of p53 can impede oncogenic Kras driven tumorigenesis in some tissues.…”
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Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…In the subsequent prognosis validation, the high-risk group included more patients with stage T3 + 4, N1 + 2 + 3, M1, and III + IV cancer; higher recurrence/metastasis rates; and lower 1, 3, and 5 year overall survival rates. In the oncogenic pathway analysis, most of the oncogenic mutations were detected in the high-risk group. …”
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Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis by Hong Lin, Jinpeng Yuan, Guoxi Liang, Yanxuan Wu, Liming Chen

“…Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. …”
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Prognostic and diagnostic significance of circRNAs expression in hepatocellular carcinoma patients: A meta‐analysis by Xin Huang, Weiyue Zhang, Zengwu Shao

“…As for clinicopathological parameters, high expression of oncogenic circRNAs had a significant association with poor clinicopathological features and tumor‐suppressor circRNAs proved the contrary. …”
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IL-17 Affects the Progression, Metastasis, and Recurrence of Laryngeal Cancer via the Inhibition of Apoptosis through Activation of the PI3K/AKT/FAS/FASL Pathways by Yang Song, Ming Yang, Hongjian Zhang, Yan Sun, Ye Tao, Huihui Li, Jing Zhang, Yuncheng Li, Jianming Yang

“…Finally, in vitro experiments demonstrated that IL-17 functioned as an oncogene by inhibiting the apoptosis of LC cells via the PI3K/AKT/FAS/FASL pathways. …”
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Inhibition of glutathione peroxidase 4 suppresses gastric cancer peritoneal metastasis via regulation of RCC2 homeostasis by Can Hu, Jingli Xu, Yanqiang Zhang, Ruolan Zhang, Siwei Pan, Jiahui Chen, Yan Wang, Qianyu Zhao, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Shengjie Zhang, Dan Zu, Zhiyuan Xu, Ji Jing, Xiangdong Cheng

“…Proteomic analysis revealed that GPx4 expression regulated the Homeostasis of RCC2, an oncogene link to epithelial-mesenchymal transition (EMT). …”
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Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer by Rui Xu, Mengyun Wan, Jiadong Pan, Jie Mei, Ji Zhou, Yan Shen, Jiayue Yang, Yichao Zhu, Jing Sun

“…Additionally, high expression of DAAM1 was associated with poor prognosis. DAAM1 acted as an oncogene in pancreatic cancer, and its inhibition suppressed tumor cell proliferation, migration, and invasion, while promoted apoptosis. …”
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A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality by Jain Nem Kumar, Tailang Mukul, Thangavel Neelaveni, Makeen Hafiz A., Albratty Mohammed, Najmi Asim, Alhazmi Hassan Ahmad, Zoghebi Khalid, Alagusundaram Muthumanickam, Jain Hemant Kumar, Chandrasekaran Balakumar

“…FDA has approved four anticancer agents such as erdafitinib, pemigatinib, infigratinib, and futibatinib, for clinical use in oncogenic FGFR-driven malignancies. These include cholangiocarcinoma, urothelial carcinoma, and myeloid/lymphoid malignancies. …”
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