Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. by Ning-xia Sun, Chen Ye, Qian Zhao, Qing Zhang, Chen Xu, Shao-bing Wang, Zhi-jun Jin, Shu-han Sun, Fang Wang, Wen Li

“…Conclusion: These results demonstrated that lncRNA-EBIC was an oncogenic lncRNA, which could promote tumor cell invasion in CC by binding to EZH2 and inhibiting E-cadherin expression.…”
Get full text

Identification of a Novel PPAR Signature for Predicting Prognosis, Immune Microenvironment, and Chemotherapy Response in Bladder Cancer by Ke Zhu, Wen Deng, Hui Deng, Xiaoqiang Liu, Gongxian Wang, Bin Fu

“…GSEA analysis indicated that PPAR signature was implicated in multiple oncogenic signaling pathways and correlated with tumor immune cell infiltration. …”
Get full text

A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets by Xinghao Fu, Feihong Ji, Qi He, Xinguang Qiu

“…Our first pan-cancer analysis offers a pretty comprehensive knowledge of YY1’s oncogenic involvement in various cancers.…”
Get full text

Establishment and Validation of a Gene Signature-Based Prognostic Model to Improve Survival Prediction in Adrenocortical Carcinoma Patients by Xiaoqin Ge, Zhenzhen Liu, Xuehua Jiao, Xueyan Yin, Xiujie Wang, Gengxu Li

“…As a secondary important finding, we report the discovery and validation of a new oncogene, TIGD1, which was consistently overexpressed in ACC. …”
Get full text

Insight of microRNA role in Colorectal Cancer by Kwan-Liang Lye, Loh Teng-Hern Tan, Hui-Min Yap

“…Mutations in the V-KiRas2 (Kras) oncogene have been implicated in 30-50% of the colorectal cancer patients and usually lead to poorer prognosis. …”
Get full text

Human papillomavirus, vaginal microbiota and metagenomics: the interplay between development and progression of cervical cancer by Paul Leon-Gomez, Vanessa I. Romero, Vanessa I. Romero

“…Persistent infection with oncogenic human papillomavirus (HPV) types, such as HPV 16 or 18, is a major factor in cervical cancer development. …”
Get full text

Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis... by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…This study focuses on MYEOV, an oncogene encoding for two protein isoforms, reported as causally involved in promoting cancer cell proliferation and metastasis in both haematological malignancies and solid tumours. …”
Get full text

Potensi Eugenol Fraksi Etil Asetat Bunga Cengkeh terhadap Proliferasi Kanker Serviks (HeLa Cell Line) by Fajri Rahendra Pratama, Annisa Permata Sari, Aprilia Susanti, Hasya Syakira, Amilia Salsabila, Dessy Arisanty

“…<p>Cervix cancer, also known as cervical cancer, is a type of cancer that is caused mainly by oncogenic Human Papillomavirus (HPV), which attacks the cervix. …”
Get full text

GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway by Wenjing Xue, Ying Li, Yanna Ma, Feng Zhang

“…Pharmacological inhibition of the TGFβ signaling pathway effectively abrogated the oncogenic activities of GDF15 in MM cells, including cell proliferation, apoptosis, and fermentation. …”
Get full text

The First Record of an Aggressive Form of Ocular Tumour Enhanced by Marek’s Disease Virus Infection in Layer Flock in Al-Najaf, Iraq by Aoula Al-Zebeeby, Ali Hadi Abbas, Haider Abas Alsaegh, Furkan Sabbar Alaraji

“…Tumours accompany MD, mostly caused by oncogenic Gallid alpha herpesvirus 2 (MD Herpes virus serotype I). …”
Get full text

Knockdown of S100A2 inhibits the aggressiveness of endometrial cancer by activating STING pathway by Chengcheng Li, Dandan Zhu, Xun Cao, Ying Li, Xiaoyuan Hao

“…Inhibition of S100A2 dramatically suppresses the tumour growth in vivo.Conclusions S100A2 functions as an oncogene in endometrial cancer. Targeting S100A2 may be a promising therapeutic method to treat endometrial carcinoma.…”
Get full text

The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat by Carolyn M. Ecelbarger, Arjun Rash, Rajesh K. Sinha, Swasti Tiwari

“…Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-β1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ. …”
Get full text

Computational approaches of modelling human papillomavirus transmission and prevention strategies: a systematic review by Weiyi Wang, Shailendra Sawleshwarkar, Mahendra Piraveenan

“…Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the world. Persistent oncogenic HPV infection has been a leading threat to global health and can lead to serious complications such as cervical cancer. …”
Get full text

Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer by Marisa Shiina, Lilly Y. W. Bourguignon

“…Together, our findings suggest that selective activation of oncogenic signaling by certain sizes of HA (e.g., 200 kDa-HA) may be instrumental in the formation of CSC functions leading to tumor cell survival and chemoresistance in head and neck cancer progression.…”
Get full text

Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trial... by Andrea Messori, Andrea Ossato, Lorenzo Gasperoni, Luna Del Bono, Alessandro Inno, Vera Damuzzo

“…Background: Immune checkpoint inhibitors (ICIs), either alone or in combination with platinum-based chemotherapy, are effective in the first-line treatment of metastatic, non-oncogene-addicted, non-small cell lung cancer (NSCLC). …”
Get full text

Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer by Alejandra M. Scursoni, Laura Galluzzo, Sandra Camarero, Jessica Lopez, Fabiana Lubieniecki, Claudia Sampor, Valeria I. Segatori, Mariano R. Gabri, Daniel F. Alonso, Guillermo Chantada, María Teresa G. de Dávila

“…No significant differences were observed between neuroblastoma with and without NMYC oncogene amplification, suggesting that expression of NeuGc-GM3 is preserved in more aggressive cancers. …”
Get full text

Highly Proliferative Immortalized Human Dental Pulp Cells Retain the Odontogenic Phenotype when Combined with a Beta-Tricalcium Phosphate Scaffold and BMP2 by Xiangfen Li, Liu Wang, Qin Su, Ling Ye, Xuedong Zhou, Dongzhe Song, Dingming Huang

“…Furthermore, highly proliferative iHDPCs displayed no oncogenicity when subcutaneously implanted into athymic nude mice. …”
Get full text

Expression analysis of nuclear factor kappa B (NF-κB) in oral squamous cell carcinoma by Dev Arora, Dhanraj M. Ganapathy, Ashikha Shirin Usman Pp, K.P. Ameya, Durairaj Sekar, Kumaravel Kaliaperumal

“…As a result, we conclude that NF-κB was found to be an important oncogene in the tumor growth and metastasis of various cancers, including OSCC. …”
Get full text

A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion by Carlotta Giani, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Alessia Tacito, Laura Valerio, Laura Agate, Clara Ugolini, Michele Marinò, Fulvio Basolo, Alessandro Franchi, Simona Borsari, Angela Michelucci, Cesare Selli, Gabriele Materazzi, Filomena Cetani, Rossella Elisei

“…Multiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by RET proto-oncogene mutation. Two different clinical variants of MEN2 are known (MEN2A and MEN2B): medullary thyroid carcinoma (MTC) almost always present and associated with pheochromocytoma (Pheo), and primary hyperparathyroidism (HPTH) in MEN2A and with Pheo and other nonendocrine diseases in MEN2B. …”
Get full text

Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression by Lei Song, Xi Yu, Yang Wu, Wenwen Zhang, Yu Zhang, Yanchi Shao, Zhenxin Hou, Chen Yang, Yue Gao, Yanbin Zhao

“…Moreover, interleukin 8 (IL8) and interleukin 10 (IL10) produced by M2‐like macrophages regulate the expression of ITGβ8 in LUAD cells through the spi‐1 proto‐oncogene (SPI1). This study elucidates the feedback mechanism of ITGβ8 between LUAD cells and macrophages.…”
Get full text