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361
HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis
Published 2025-02-01“…Objectives: This study aims to investigate the functional implications of UPF3B-S (a truncated oncogenic splice variant) in HCC metastasis. Methods: Basescope assay was performed to analyze the expression of UPF3B-S mRNA in tissues and cells. …”
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362
Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription
Published 2025-01-01“…Functionally, the PDE5 inhibitor sildenafil exhibited the suppressive ability to prevent oncogenic growth in GC. Mechanistically, sildenafil restrained GC growth by directly activating PKG through PDE5 inhibition for regulating c-MYC expression via its phosphorylation and ubiquitination degradation, thereby suppressing c-MYC stability for IL-6 transcription within the downstream IL-6/JAK/STAT3 signalling pathway. …”
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363
PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells
Published 2025-01-01“…The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. Nevertheless, there is limited knowledge regarding its function in SCLC. …”
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364
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Published 2025-01-01“…RNA sequencing in cells treated with T6I-29 reveals a neomorphic downregulation of DKK1, a secreted glycoprotein known to play oncogenic roles in other cancers. Importantly, we find that DKK1 is significantly enriched in ER + breast cancer plasma compared to healthy controls. …”
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365
Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer
Published 2025-01-01“…Exome sequencing analysis further identified significant somatic oncogenic drivers and revealed a dominant mutational signature SBS3 across BRCA1/2-negative samples, reinforcing the contribution of omologous recombination deficiency underlying the MBC development. …”
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366
USP8‐Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression
Published 2025-01-01“…ABSTRACT Background Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy, and the molecular underpinnings of its aggressive behavior are not fully understood. FYN proto‐oncogene, Src family tyrosine kinase (FYN) has been linked to cancer progression, yet its role in ESCC remains elusive. …”
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367
Proximal bronchiolar adenoma with malignant transformation to invasive mucinous adenocarcinoma with 4 years follow-up: a case report and literature review
Published 2025-01-01“…Hybridization Capture-based next-generation sequencing (NGS) analysis detected driver gene mutations in Kirsten Rat Sarcoma viral oncogene homolog (KRAS) and Cyclin-Dependent Kinases (CDK) 6 in the case, thereby inferring the malignant transformation of BA into IMA.ConclusionIn this case, the detection of driver gene KRAS mutation and loss of continuity in the basal cell layer within the mucous glandular structures of the nodule suggests the malignant transformation of BA into IMA, inferring the malignant potential of BA.…”
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368
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
Published 2025-01-01“…These effects were accompanied by enhanced H3K9 histone acetylation (H3K9ac) and decreased expression of the <i>MYC</i> oncogene. VPA impaired the expansion of MB neurospheres enriched in stemness markers and reduced <i>MYC</i> while increasing <i>TP53</i> expression in these neurospheres. …”
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369
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer
Published 2023-10-01“…Herein, we refine the oncogenic role of ERRα in the pyroptosis pathway and glycolytic metabolism. …”
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370
NCAPD3‐mediated AKT activation regulates prostate cancer progression
Published 2025-02-01“…Moreover, there was a positive mutual activation between STAT3 and JAK2, further enhanced by NCAPD3 to promote PCa progression. NCAPD3, as an oncogene, promoted PCa progression by phosphorylating and activating AKT, which suggests a novel functional pathway of NCAPD3 in promoting PCa progression.…”
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371
Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness
Published 2025-01-01“…Conclusions In summary, miR-1307-5p reduces angiogenesis in breast cancer, thereby antagonizing the oncogenic effects of miR-1307-3p. Our results emphasize the importance of future research on the regulation of miRNA arm selection in cancer. …”
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372
T cell receptors specific for an imatinib-induced mutation in BCR-ABL for adoptive T cell therapy
Published 2025-01-01“…BCR-ABL kinase is the major oncogenic driver of chronic myeloid leukemia (CML). …”
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373
Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting
Published 2025-02-01“…Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD). …”
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374
Black Chokeberry (<i>Aronia melanocarpa</i>) Juice Supplementation Affects Age-Related Myocardial Remodeling in Rats
Published 2024-12-01“…Furthermore, the angiotensin converting enzyme 2 (ACE2) immunoexpression in the myocardium increased by 37% (<i>p</i> < 0.05) and the Proto-oncogene Mas receptor (MAS1) immunoexpression increased by 6% (<i>p</i> < 0.05) in the AMJ group, as compared to CO. …”
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375
Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas
Published 2018-09-01“…CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600E ), which has attracted considerable attention in clinical trials for the treatment of human cancers. …”
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376
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development
Published 2025-01-01“…SIRT5 exhibits dual functionalities: it can promote tumor proliferation, metastasis, drug resistance, and metabolic reprogramming, thereby acting as an oncogene; conversely, it can also inhibit tumor cell growth and induce apoptosis, functioning as a tumor suppressor gene. …”
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377
Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation
Published 2018-01-01“…Ir-6 also inhibited ATP-release, intracellular Ca2+ mobilization, P-selectin expression, and the phosphorylation of phospholipase Cγ2 (PLCγ2), protein kinase C (PKC), v-Akt murine thymoma viral oncogene (Akt)/protein kinase B, and mitogen-activated protein kinases (MAPKs), in collagen-activated platelets. …”
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378
CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment
Published 2025-03-01“…In vitro and in vivo assays were performed to investigate the oncogenic function of CSF3 in the tumor associated malignant phenotypes and the tumorigenic capability of CRC cells. …”
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379
Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
Published 2025-12-01“…ALA downregulated hTERT oncogene while upregulating the mRNA expression of TSGs (Tumor Suppressor Genes) CDH1, RARβ, and DAPK in all the cell lines. …”
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380
High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma
Published 2023-01-01“…TET1 was closely involved in immune infiltration and activation of oncogenic pathways. The DNA demethylation-related risk model was potential to be applied for predicting HCC prognosis in clinics.…”
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