Comparison of differences in transcriptional and genetic profiles between intra-central nervous system and extra-central nervous system large B-cell lymphoma by Shu Wang, Hong Chen, Bo Dai, Kang Zheng, Jiajun Zheng, Yuqi Zhu, Yan Yuan, Tianling Ding, Qian Wang, Liqian Xie, Rui Feng, Fengping Zhu, Jianbin Xiang, Weiqun Ding, Hong Ding, Yuan Li, Xiaodong Gu, Kunpeng Wu, Yifan Yuan, Jianping Song, Dongxiao Zhuang, Haoshu Zhong, Hanfeng Wu, Ying Mao, Tong Chen

“…In summary, our study provides comprehensive insights into the transcriptomic and genetic characteristics of PCNS-DLBCL in contrast to ecDLBCL and will help dissect the oncogenic mechanism of this disease.…”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. …”
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Expression Levels of Some Antioxidant and Epidermal Growth Factor Receptor Genes in Patients with Early-Stage Non-Small Cell Lung Cancer by Giuseppe De Palma, Paola Mozzoni, Olga Acampa, Eveline Internullo, Paolo Carbognani, Michele Rusca, Matteo Goldoni, Massimo Corradi, Marcello Tiseo, Pietro Apostoli, Antonio Mutti

“…Antioxidant genes included heme oxygenase 1 (HO-1), superoxide dismutase-1 (SOD-1), and -2 (SOD-2), whereas epidermal growth factor receptor genes consisted of epidermal growth factor receptor (EGFR) and v-erb-b2 erythroblastic leukaemia viral oncogene homolog 2 (HER-2). Twenty-eight couples of lung biopsies were obtained and gene transcripts were quantified by Real Time RT-PCR. …”
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Role of silent mutations in KRAS-mutant tumors by Jun Lu, Chao Zhou, Feng Pan, Hongyu Liu, Haohua Jiang, Hua Zhong, Baohui Han, Xiangxiang Pan

“…Kirsten-RAS (KRAS) mutations, predominantly oncogenic, are pivotal drivers in various cancers. …”
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Targeting KRAS‐mutant pancreatic cancer through simultaneous inhibition of KRAS, MEK, and JAK2 by Satoru Miyazaki, Masato Kitazawa, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Masahiro Kataoka, Hirokazu Tanaka, Michiko Takeoka, Daisuke Komatsu, Yuji Soejima

“…The Kirsten rat sarcoma (KRAS) oncogene was considered “undruggable” until the development of sotorasib, a KRASG12C selective inhibitor that shows favorable effects against lung cancers. …”
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Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle by Mohammed A. Hamad, Ahmed M. Al-Shammari, Shoni M. Odisho, Nahi Y. Yaseen

“…BPV is a widely spread oncogenic virus in Iraqi cattle and is associated with the formation of both benign and malignant lesions, resulting in notable economic losses in dairy and beef cattle. …”
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Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells by HyunJun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben Pathak, William Graff, Alexis LeVee, Jun Wu, Mark A. LaBarge, David Frankhouser, Russell C. Rockne, Patrick Pirrotte, Bin Zhang, Joanne Mortimer, Le Xuan Truong Nguyen, Guido Marcucci

“…OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro. OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo models, i.e., cell line-derived (CDX), patient-derived (PDX), and mammary fat pad xenografts. …”
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Melanoma genomics – will we go beyond BRAF in clinics? by Justyna Mirek, Wiesław Bal, Magdalena Olbryt

“…However, evaluating the oncogene BRAF mutation in codon V600 is still the only companion diagnostic genomic test commonly implemented in clinics for molecularly targeted treatment of advanced melanoma. …”
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Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma by Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu

“…Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of polyamine metabolism and its effects on the immune microenvironment and response to immunotherapy in HCC remain unclear. …”
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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are found in 90% of PDAC cases, and tumors dependent on KRAS (dKRAS) can be identified using gene expression signature scores. …”
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Isolation of Viral Biofilms From HTLV-1 Chronically Infected T Cells and Integrity Analysis by Coline Arone, Hélène Dutartre, Delphine Muriaux

“…The human T-lymphotropic virus type-1 (HTLV-1) is an oncogenic retrovirus that predominantly spreads through cell-to-cell contact due to the limited infectivity of cell-free viruses. …”
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Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…The dissemination of pathogens through the circulation may contribute to the establishment of an immune-suppressive environment that promotes carcinogenesis in extraintestinal organs either directly or indirectly. The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. …”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…In this report, we also discuss the oncogenic potential of BK virus, the use of checkpoint inhibitors in urothelial carcinoma, and the feasibility of retransplant for this patient population.…”
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Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype by Elena I. Dyachenko, Lyudmila V. Bel’skaya

“…In addition to the main signaling pathway PI3K/Akt/mTOR, the activity of the oncogene c-Myc, HIF, p53, GATA2, NF-kB and MAT2A have a direct effect on the amino acid metabolism of cancer cells, their growth and proliferation, as well as the maintenance of homeostatic equilibrium. …”
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells by Yun Zhao, Shanel Dhani, Vladimir Gogvadze, Boris Zhivotovsky

“…Previously, we demonstrated the oncogenic role of Tudor Staphylococcal nuclease (TSN, also known as Staphylococcal nuclease domain-containing protein 1, SND1), in regulating chemoresistance in NSCLC cells. …”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…The in vivo ubiquitination assay showed that FBXW7 repressed HCC malignancy by regulating the oncogenic activity of ACTL6A in a ubiquitin-dependent manner. …”
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YPEL2 regulates the efficacy of BRD4-EZH2 dual targeting in EZH2Y641mut germinal center-derived lymphoma by Aránzazu Chamorro-Jorganes, Núria Profitós-Pelejà, Clara Recasens-Zorzo, Juan G Valero, Diana Reyes-Garau, Laura Magnano, Ray Butler, Antonio Postigo, Patricia Pérez-Galán, Marcelo Lima Ribeiro, Gaël Roué

“…While this factor is known to cooperate with the proto-oncogene MYC during malignant B cell development, the effect of interfering with both factors remains underexplored. …”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Moreover, our investigation identified FUT8, a fucosyltransferase, as a potential target for morusinol. FUT8’s role as an oncogene in DLBCL and its correlation with poor survival further underscored its significance. …”
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Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings by Rong Li, Songzuo Yu, Xiao Liang, Yu Li, Keng Po Lai

“…Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. …”
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Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis by Mio Takahashi, Kohei Nakamura, Tatsuyuki Chiyoda, Chihiro Okada, Sachio Nohara, Reika Takamatsu, Shintaro Yanazume, Hiroaki Kobayashi, Hiroshi Nishihara, Wataru Yamagami

“…Furthermore, the transcriptomic data highlighted a novel and substantial similarity between BOTs and EC, suggesting deeper biological linkages, including potentially shared oncogenic pathways or tumor microenvironmental factors. …”
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