Showing 181 - 200 results of 430 for search '"oncogenes"', query time: 0.05s Refine Results
  1. 181

    Restriction Enzyme Analysis of DNA Methylation in “Condensed” Chromatin of Ha-Ras-Transformed NIH 3T3 Cells by Maria Luiza S. Mello, Ann F. Chambers, Benedicto C. Vidal, Wolfgang Planding, Ulrich Schenck

    Published 2000-01-01
    “…., localized areas of high DNA density, or chromatin higher order packing state) have been described in NIH 3T3 cells transformed with the Ha‐ras oncogene. The structural basis for this oncogene‐mediated alteration in nuclear organization is unknown. …”
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  2. 182
  3. 183

    Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival by Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk

    Published 2025-01-01
    “…Compared to partial glucose uptake inhibition, dependency on mitochondrial respiration is less apparent suggesting robust blockage of glucose uptake is essential to create a metabolic vulnerability. When wild-type and oncogenic RAS patient-derived induced pluripotent stem cell acute myeloid leukemia (AML) models were examined, KL-11743 mediated induction of mitochondrial respiration and dependency for survival associated with oncogenic RAS. …”
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  4. 184

    Cervical uterine cancer: prevention and treatment by Eneida Bravo Polanco, Narciso Águila Rodríguez, Dayamí Guerra Villarpanda, Yamiley Blanco Vázquez, Oskeimy Rodríguez González, Madelín Oliva Santana

    Published 2020-08-01
    “…Cervical uterine cancer is a cellular alteration which starts in the cervix epithelium due to the persistence of human papillomavirus oncogenic serotypes and that initially manifests itself through precancerous lesions of slow and progressive evolution. …”
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  5. 185

    Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer by Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

    Published 2025-01-01
    “…The integrin-linked kinase (ILK) gene has been identified as an oncogenic driver in hormonal cancers, including PCa. …”
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  6. 186

    Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

    Published 2025-01-01
    “…These findings form a promising foundation for future research on oncogenic RTKs and the application of cell-free systems for synthesising functional membrane proteins.…”
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  7. 187
  8. 188

    TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

    Published 2023-01-01
    “…Mechanistic studies revealed that high TMEM147 expression was linked to the B lymphocyte, antigen response, IL6 signaling pathway, cell cycle, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling pathway, and myelocytomatosis oncogene (MYC) targets. …”
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  9. 189

    The Expression and Action of Decay-Accelerating Factor (CD55) in Human Malignancies and Cancer Therapy by Jan-Henrik Mikesch, Kathrin Schier, Antje Roetger, Ronald Simon, Horst Buerger, Burkhard Brandt

    Published 2006-01-01
    “…Here DAF seems to exert different functions beyond its immunological role such as e.g. promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding. …”
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  10. 190

    Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

    Published 2012-01-01
    “…As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.…”
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  11. 191

    Hepatitis C Virus and Nonliver Solid Cancers: Is There an Association between HCV and Cancers of the Pancreas, Thyroid, Kidney, Oral Cavity, Breast, Lung, and Gastrointestinal Trac... by Saad Qadwai, Tayyaba Rehman, Jonathan Barsa, Zeeshan Solangi, Edward Lebovics

    Published 2017-01-01
    “…Hepatitis C virus (HCV) is known for its oncogenic potential and has been found to be associated with hepatocellular carcinoma (HCC) and non-Hodgkin lymphoma. …”
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  12. 192

    Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

    Published 2025-02-01
    “…Targeting TFF3 with an interfering RNA plasmid or a small-molecule inhibitor (AMPC) inhibited these oncogenic characteristics, highlighting the therapeutic potential of targeting TFF3 in ER+HER2+ MC. …”
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  13. 193

    Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

    Published 2020-01-01
    “…Functionally, knockdown of B7-H6 in GSLCs by siRNAs led to the inhibition of cell proliferation, with decrease in the expression of the oncogene Myc as well as inactivation of PI3K/Akt and ERK/MAPK signaling pathways. …”
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  14. 194

    PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer by Diyou Li, Yinglin Pan, Yating Huang, Ping Zhang, Xuhong Fang

    Published 2018-01-01
    “…P21cdc42/rac1-activated kinase 5 (PAK5) is a newly identified protein that has been indicated to have oncogenic potential. The present study investigated the expression level of PAK5 in clinical ovarian cancer and the functional roles of PAK5 in ovarian cancer progression. …”
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  15. 195

    Portrait of WWP1: the current state in human cancer by Jiaming Lei, Jun Chen, Wenwen Yu, Qing Wu, Shuang Jing, Yuanguang Tang, Li Lin, Meichun Hu

    Published 2025-01-01
    “…WWP1 demonstrates a dual function, acting predominantly as an oncogene in tumors but occasionally as a tumor suppressor. …”
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  16. 196

    Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults by Anna Koumarianou, Panagiota Oikonomopoulou, Margarita Baka, Dimitrios Vlachodimitropoulos, Stylianos Argentos, Theodoros Piperos, Maria-Ioanna Christodoulou, Kakoulis Theodoulou, Theodoros Mariolis-Sapsakos

    Published 2013-01-01
    “…MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. …”
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  17. 197

    PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers by Nobendu Mukerjee, Dattatreya Mukherjee

    Published 2025-12-01
    “…Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies.…”
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  18. 198

    Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature by Carlos Zagalo, Francesca Pierdomenico, José Cabeçadas, Pedro David Santos

    Published 2013-01-01
    “…The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. …”
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  19. 199

    Inhibition of miMOMP-induced SASP to combat age-related disease by Xiaoli Liao, Zhennan Guo, Zhennan Guo, Mouhai He, Yichun Zhang

    Published 2025-01-01
    “…This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). …”
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  20. 200

    The Role of Leukotriene Receptor Signaling in Inflammation and Cancer by Ramin Massoumi, Anita Sjölander

    Published 2007-01-01
    “…In addition, we delineate how continuous CysLT1 receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.…”
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