INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform by Chun Ngo Yau, Jacky Tin Shing Hung, Robert A. A. Campbell, Thomas Chun Yip Wong, Bei Huang, Ben Tin Yan Wong, Nick King Ngai Chow, Lichun Zhang, Eldric Pui Lam Tsoi, Yuqi Tan, Joshua Jing Xi Li, Yun Kwok Wing, Hei Ming Lai

“…We anticipate that INSIHGT can form the foundations for 3D spatial multi-omics technology development and holistic systems biology studies.…”
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…Future researches should develop multi-omics technology to identify patients who benefit from polyphenols combination drugs and devising individualized treatment plans to enhance its therapeutic effect.…”
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Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases by Chang Youn Lee, Ran Kim, Onju Ham, Jihyun Lee, Pilseog Kim, Seokyeon Lee, Sekyung Oh, Hojin Lee, Minyoung Lee, Jongmin Kim, Woochul Chang

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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The MLH1 co-expression network was established based on the LinkedOmics database. This study found that the expression of MSH2, MSH6 and PMS2 was up-regulated in STAD tissues. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…Finally, we explore the potential for personalized treatment strategies incorporating multi-omics data to optimize therapeutic outcomes. The integration of epigenetic therapies and immunotherapy offers a promising avenue for improving survival in TNBC patients.…”
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The genomes of Scedosporium between environmental challenges and opportunism by Francesco Venice, Federica Spina, Domenico Davolos, Stefano Ghignone, Giovanna Cristina Varese

“…Many efforts have been made to understand the mechanisms underlying pathogenicity in bacteria, and OMICs techniques are largely responsible for those advancements. …”
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Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer by Rui Xu, Mengyun Wan, Jiadong Pan, Jie Mei, Ji Zhou, Yan Shen, Jiayue Yang, Yichao Zhu, Jing Sun

“…Methods Multiple public datasets and an in-house cohort were utilized to assess the clinical relevance of DAAM1 in pancreatic cancer. The LinkedOmics platform was employed to perform enrichment analysis of DAAM1-associated molecular pathways in pancreatic cancer. …”
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Evaluation of imputation performance of multiple reference panels in a Pakistani population by Jiayi Xu, Dongjing Liu, Arsalan Hassan, Giulio Genovese, Alanna C. Cote, Brian Fennessy, Esther Cheng, Alexander W. Charney, James A. Knowles, Muhammad Ayub, Roseann E. Peterson, Tim B. Bigdeli, Laura M. Huckins

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A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…However, the underlying molecular mechanisms remain poorly understood. Disease-related “omics” data provide a comprehensive overview of gene relationships, helping to decode the complex molecular mechanisms involved. …”
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Metabolic interactions underpinning high methane fluxes across terrestrial freshwater wetlands by Emily K. Bechtold, Jared B. Ellenbogen, Jorge A. Villa, Djennyfer K. de Melo Ferreira, Angela M. Oliverio, Joel E. Kostka, Virginia I. Rich, Ruth K. Varner, Sheel Bansal, Eric J. Ward, Gil Bohrer, Mikayla A. Borton, Kelly C. Wrighton, Michael J. Wilkins

“…To address this, we integrate 16S rRNA amplicon datasets, metagenomes, metatranscriptomes, and annual methane flux data across 9 wetlands, creating the Multi-Omics for Understanding Climate Change (MUCC) v2.0.0 database. …”
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Hidden route of protein damage through oxygen-confined photooxidation by Seoyoon Kim, Eojin Kim, Mingyu Park, Seong Ho Kim, Byung-Gyu Kim, Seungjin Na, Victor W. Sadongo, W. C. Bhashini Wijesinghe, Yu-Gon Eom, Gwangsu Yoon, Hannah Jeong, Eunhye Hwang, Chaiheon Lee, Kyungjae Myung, Chae Un Kim, Jeong-Mo Choi, Seung Kyu Min, Tae-Hyuk Kwon, Duyoung Min

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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

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Designing innovation ecosystems for biointelligent value creation – Identification of promising technology fields and pioneer countries by Michael Rentschler, Silja Hohmann, Philipp Heuermann, Livio Valenti, Robert Miehe

“…Based on the data collected, our analysis results in a systematic derivation of five enabling technology fields assessed as particularly promising in connection with biointelligent value creation: smart greenhouses and smart farming, biorefineries and bioreactors, bio-computing and data storage, omics, as well as biosensors and bioactuators. Countries such as Israel, Finland, the USA, Canada, and Germany can be named pioneers in biointelligent value creation. …”
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Current molecular understanding of central nervous system schwannomas by Takahiro Tsuchiya, Satoru Miyawaki, Yu Teranishi, Kenta Ohara, Yudai Hirano, Shotaro Ogawa, Seiei Torazawa, Yu Sakai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito

“…Furthermore, the advent of advanced techniques like single-cell sequencing and multi-omics analysis has facilitated rapid discoveries related to the tumor microenvironment and tumor heterogeneity in schwannomas. …”
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Exploration of interstitial fluid proteome in Homo sapiens forearm through a cutting edge intradermal microdialysis and high-throughput proteomics approach: a pilot study by Yu Sakamoto, Naoto Fujii, Junko Shibato, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ranjith Kumar Bakku, Randeep Rakwal

“…Abstract There has been increasing interest in utilizing biofluids in combination with high-throughput omics to identify biomarkers, to unravel mechanisms underlying internal physiological environments. …”
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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“…Future research integrating omics approaches (e.g., transcriptomics, proteomics, metabolomics) will provide deeper insights into the molecular mechanisms that regulate stress tolerance, to aid in the development of more resilient carrot varieties suitable for cultivation under adverse environmental conditions.…”
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Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…Our approach involves a multi-omics analysis of IFI30 tumor immunological profile in the macrophage-mediated Tumor Microenvironment (TME), spanning various cancers and bolstered by rigorous co-culture laboratory work.ResultsIFI30 predominantly localizes in monocyte/macrophage populations, correlating strongly with immune cell infiltration. …”
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Rating pome fruit quality traits using deep learning and image processing by Nhan H. Nguyen, Joseph Michaud, Rene Mogollon, Huiting Zhang, Heidi Hargarten, Rachel Leisso, Carolina A. Torres, Loren Honaas, Stephen Ficklin

“…Integrative analyses enhanced by Granny's improved resolution and reduced bias, such as linking fruit outcomes to global scale ‐omics data, environmental changes, and other quantitative fruit quality metrics like soluble solids content and flesh firmness, will further enrich our understanding of fruit quality dynamics. …”
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Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…To determine specific markers of diseases, various omics technologies are applied, including metabolomics, which makes it possible to evaluate the content of low-molecular compounds – amino acids, lipids, carbohydrates, nucleic acids fragments – in biological samples available for clinical analysis (blood and urine). …”
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Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with X1X1X2X2/X1X2Y chromosom... by Haixia Zhao, Jun Li, Zhizhong Xiao, Yongshuang Xiao

“…Through an examination of sex-related genes (dmrt1, hsd11b2, amh, sox9a, sox9b, foxl2, cyp19a), hormonal influences (E2, 11-KT), and histological analyses of gonadal development, we demonstrate that the critical period for sexual differentiation occurs between 35 to 60 days post-hatching (dph). Our multi-omics analysis identified amhr2 as a candidate sex-determining gene, revealing that the males possess three distinct amhr2 transcripts (amhr2ay, amhr2by, amhr2cy), whereas females express only one (amhr2a). …”
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