Computational frameworks transform antagonism to synergy in optimizing combination therapies by Jinghong Chen, Anqi Lin, Aimin Jiang, Chang Qi, Zaoqu Liu, Quan Cheng, Shuofeng Yuan, Peng Luo

“…This review systematically analyzes computational methods for predicting drug combination effects through multi-omics data integration. We comprehensively assess key algorithms including DrugComboRanker and AuDNNsynergy, and evaluate integration approaches encompassing kernel regression and graph networks. …”
Get full text

Importance of Human Faecal Biobanking: From Collection to Storage by Lewandowska Izabela, Grzech Katarzyna, Krzysztoń-Russjan Jolanta

“…The review includes research on faecal microbiota transplantation (FMT), microbiome analysis, ‘-omics’ research, cancer and parasites. The primary topic addressed in this research is the impact of storage conditions and freezing methods for faecal samples on the stability and diversity of the gut microbiome. …”
Get full text

Microbial community structure and functional traits involved in the adaptation of culturable bacteria within the gut of amphipods from the deepest ocean by Yukun Cui, Yu Xiao, Zhuo Wang, Paiyao Ji, Changhao Zhang, Yongqi Li, Jiasong Fang, Xi Yu

“…This not only complements the current omics-dominated field but also paves the way for future resource development of extreme microbes. …”
Get full text

Bioinformatics services for analyzing massive genomic datasets by Gunhwan Ko, Pan-Gyu Kim, Youngbum Cho, Seongmun Jeong, Jae-Yoon Kim, Kyoung Hyoun Kim, Ho-Yeon Lee, Jiyeon Han, Namhee Yu, Seokjin Ham, Insoon Jang, Byunghee Kang, Sunguk Shin, Lian Kim, Seung-Won Lee, Dougu Nam, Jihyun F. Kim, Namshin Kim, Seon-Young Kim, Sanghyuk Lee, Tae-Young Roh, Byungwook Lee

“…Bio-Express is loaded with predefined multi-omics data analysis pipelines, which are divided into genome, transcriptome, epigenome, and metagenome pipelines. …”
Get full text

Allele frequency of pathogenic variants causing acid sphingomyelinase deficiency and Gaucher disease in the general Japanese population by Shuhei Sako, Kimihiko Oishi, Hiroyuki Ida, Eri Imagawa

“…Here, we reviewed the allele frequencies of pathogenic variants causing ASMD and GD in the Japanese population and populations with various ancestry backgrounds using the Japanese Multi-Omics Reference Panel 54KJPN and the Genome Aggregation Database v4.0.0. …”
Get full text

A COMPREHENSIVE REVIEW ON-APPLICATION AND FUTURE PROSPECT OF CYTOPLASMIC MALE STERILITY by Sujan Chapagain

“…Moreover, the review elucidates on the recent advancements in biotechnology, omics technologies, and breeding approaches, which promise to further harness the potential of CMS in addressing global food security challenges. …”
Get full text

Integrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders by Yue Ge

“…New Approach Methodologies (NAMs)—including high-throughput screening (HTS), OMICS technologies, computational modeling, and advanced in vitro systems—offer transformative tools to tackle these challenges. …”
Get full text

Biological Aging and Venous Thromboembolism: A Review of Telomeres and Beyond by Rafaela Vostatek, Cihan Ay

“…In the last decade, advancements in omics methodologies provided insights into the molecular complexity of biological aging. …”
Get full text

Synergistic effects of mutation and glycosylation on disease progression by Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh

Get full text

Comparison of metabarcoding taxonomic markers to describe fungal communities in fermented foods by Rué, Olivier, Coton, Monika, Dugat-Bony, Eric, Howell, Kate, Irlinger, Françoise, Legras, Jean-Luc, Loux, Valentin, Michel, Elisa, Mounier, Jérôme, Neuvéglise, Cécile, Sicard, Delphine

Get full text

Identification of Potential Biomarkers and Metabolic Changes in the Serum of Breast Lump Patients Among Kelantanese Based on 1H NMR Metabolomics by Ahmad Zulkefly, Wan Norlina Wan Azman, Julia Omar, Nurul Syakima Ab Mutalib, Desy Fitrya Syamsumir, M Maulidiani, Faridah Abas, Maya Mazuwin Yahya, Muhamad Syahmi Yamin, Wan Faiziah Wan Abdul Rahman, Tengku Ahmad Damitri Al-Astani Tengku Din

“…However, further research and integration with other ‘omics’ technologies are necessary for clinical translation. …”
Get full text

Proteomic dataset of sorghum leaf and root responses to single and combined drought and heat stress by Ali Elnaeim Elbasheir Ali, Robert E. Sharp, Laura Greeley, Scott C. Peck, David L. Tabb, Ndiko Ludidi

“…Interpretation as well as integration of these proteomics data with other ‘omics’ signatures may highlight key mechanisms involved in sorghum adaptations to these stresses.…”
Get full text

Review of statistical methods for survival analysis using genomic data by Seungyeoun Lee, Heeju Lim

“…However, with the development of high-throughput technologies for producing “omics” data, more advanced statistical methods, such as regularization, should be required to construct the predictive survival model with high-dimensional genomic data. …”
Get full text

Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii by Jack C. Leo

Get full text

Increased FOXM1 Expression was Associated with the Prognosis and the Recruitment of Neutrophils in Endometrial Cancer by Jing Chen, Pusheng Yang, Shaojing Li, Yichen Feng

“…Bioinformatics analysis, including GEPIA, TIMER, cBioPortal, LinkedOmics, and STRING were used to analyze the FOXM1 gene expression, genetic alteration, and immune cell infiltration in EC. …”
Get full text

QCanvas: An Advanced Tool for Data Clustering and Visualization of Genomics Data by Nayoung Kim, Herin Park, Ningning He, Hyeon Young Lee, Sukjoon Yoon

“…We developed a user-friendly, interactive program to simultaneously cluster and visualize omics data, such as DNA and protein array profiles. …”
Get full text

EpigenomeViewer: A Shiny Web Application for Visualizing Methylation Patterns Across Biological Samples by Nurul Syakima Ab Mutalib

“…Future developments include expanded support for multi-omics data and additional gene ontology features. …”
Get full text

Metabonomics Research Progress on Liver Diseases by Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu

“…Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. …”
Get full text

BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats by Ying Wang, Guang Li, Guofeng Li, Yutao Pan, Zhongmin Liu

“…Methods Bioinformatics was completed in Link omics. GO analysis and KEGG analysis were carried out, and the grope tool of Link omics database was used to evaluate PPI information and other core path analysis information. …”
Get full text

A CACTA-like transposon in the Anthocyanidin synthase 1 (Ans-1) gene is responsible for apricot fruit colour in the raspberry (Rubus idaeus) cultivar 'Varnes'. by Daniel James Sargent, Matteo Buti, Stefan Martens, Claudio Pugliesi, Kjersti Aaby, Dag Røen, Chandra Bhan Yadav, Felicidad Fernández Fernández, Muath Alsheikh, Jahn Davik, R Jordan Price

“…In this investigation, we used a multi-omics approach to elucidate the genetic basis of the apricot fruit colour in raspberry. …”
Get full text