Systemic Diseases in Patients with Congenital Aniridia: A Report from the Homburg Registry for Congenital Aniridia by Jessica Obst, Fabian N. Fries, Maryam Amini, Annamária Náray, Cristian Munteanu, Tanja Stachon, Shweta Suiwal, Neil Lagali, Berthold Seitz, Barbara Käsmann-Kellner, Nóra Szentmáry

“…Systemic diseases were detected in 155 of 337 (46%) patients, with the most common being obesity (29 [8.6%]), thyroid disease (28 [8.3%]), hypertension (26 [7.7%]), intellectual disability (22 [6.5%]), diabetes mellitus (19 [5.6%]), auditory perception disorder/speech development delay (16 [4.7%]), and epilepsy (12 [3.6%]). …”
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Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice by Han Wang, Lizi Zhang, Xing Chen, Lingzi Hong, Junjie Zhao, Wen Qian, Lam Khue Pham, Belinda Willard, Xiaoxia Li, Katarzyna Bulek, Xiao Li

“…Dysregulated adipose and mitochondrial metabolism contributes to obesity, highlighting the need to understand their interplay. …”
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Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents by Amilton Dos Santos-Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Osmar Henrique Della Torre, Lúcia Arisaka Paes, Adriana Perez Ferreira-Neto, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo

“…To identify the frequency of obesity and metabolic complications in child and adolescent users of risperidone. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…Pharmacological inhibition of ESRRA protects obese mice against bone loss and high marrow adiposity. …”
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Search for signals of positive selection of circadian rhythm genes <i>PER1</i>, <i>PER2</i>, <i>PER3</i> in different human populations by A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva

“…In addition, many of the selection variants in the PER1, PER2, PER3 genes appear to regulate biological processes that are associated with major modern diseases, including obesity, cancer, metabolic syndrome, bipolar personality disorder, depression, rheumatoid arthritis, diabetes mellitus, lupus erythematosus, stroke and Alzheimer’s disease, making them extremely interesting targets for further research aimed at identifying the genetic causes of human disease.…”
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Risk Factors for Coronary Events After Robotic Hybrid Off-Pump Coronary Revascularization by Aleksander Dokollari, Beatrice Bacchi, Serge Sicouri, Francesco Cabrucci, Massimo Bonacchi, Danielle Spragan, Mary Ann C. Wertan, Nitin Ghorpade, Stephanie Kjelstrom, Georgia Montone, Yoshiyuki Yamashita, Basel Ramlawi, Francis Sutter

“…The risk factors were the lack of radial artery graft use, black race, diabetes, obesity, chronic obstructive pulmonary disease, low ejection fraction <50%, severe left main coronary artery stenosis (>50%), and more than three-vessel disease. …”
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Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice by Yan Yang, Wenting Zhang, Xiaohui Wu, Jing Wu, Chengjun Sun, Feihong Luo, Zhou Pei

“…Our recent study demonstrated that growth differentiation factor 5 (GDF5) could promote white adipose tissue thermogenesis and alleviate high-fat diet- (HFD-) induced obesity in fatty acid-binding protein 4- (Fabp4-) GDF5 transgenic mice (TG). …”
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Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways by Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…Sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase-4 (DPP-4) inhibitors are glucose-lowering drugs whose anti-inflammatory properties have recently become useful in tackling metabolic syndromes in chronic inflammatory diseases, including diabetes and obesity. We investigated whether empagliflozin (SGLT2 inhibitor) and gemigliptin (DPP-4 inhibitor) improve inflammatory responses in macrophages, identified signalling pathways responsible for these effects, and studied whether the effects can be augmented with dual empagliflozin and gemigliptin therapy. …”
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Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus by Sandra Mrozinska, Piotr Radkowski, Tomasz Gosiewski, Magdalena Szopa, Malgorzata Bulanda, Agnieszka H. Ludwig-Galezowska, Iwona Morawska, Agnieszka Sroka-Oleksiak, Bartlomiej Matejko, Przemyslaw Kapusta, Dominika Salamon, Maciej T. Malecki, Pawel Wolkow, Tomasz Klupa

“…There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity. There are no data, however, on the gut microbiome structure in monogenic forms of the disease including Maturity Onset Diabetes of the Young (MODY). …”
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Prevalence of and Risk factors associated with hypertension: a community based- cross sectional study in Ndorwa West Health Sub District, Kabale district, southwestern Uganda. by Munezero,Tamu John Bosco, Mfitumukiza, Valence, Okafor, Christiana Nkiru, Mandera, Immaculate, Kabami, Jane, Arineitwe, Edward Bwengye, Namuyibwa, Lydia, Izo, Herbert, Baikaitwoha, Everd M., Okonkwo, Uchenna Prosper

“…Behavioral factors associated with HT included awareness of the BP status (p = 0.010, OR = 0.53(CI: 0.32–0.87),use of fats/oil for cooking (p = 0.02, OR = 1.73 (CI: 1.09–2.75)), reduced salt intake (p = 0.001, OR = 0.075(CI:0.01–0.55)), and overweight and obesity (BMI) level ( p = 0.010, OR = 1.77 (CI 1.12–2.80)). …”
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Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized... by Yining Lu, Julien S. Baker, Shanshan Ying, Yichen Lu

“…Greater improvements were found in individuals with overweight/obesity or T2D in protocols with longer intervals or accumulated interval duration per session/week. …”
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Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease by Jean Dallongeville, Carlos Iribarren, Jean Ferrières, Liisa Lyon, Alun Evans, Alan S. Go, Dominique Arveiler, Stephen P. Fortmann, Pierre Ducimetière, Mark A. Hlatky, Philippe Amouyel, Audrey Southwick, Thomas Quertermous, Aline Meirhaeghe

“…Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor γ (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) and coronary heart disease (CHD) in the PRIME (249 cases/494 controls, only men) and ADVANCE (1,076 cases/805 controls, men or women) studies. …”
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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals by Yuanyuan Zhang, Xianhui Qin, Chengzhang Liu, Chun Zhou, Mengyi Liu, Panpan He, Ziliang Ye, Qiguo Meng, Yuanxiu Wei, Xinyue Su

“…A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension, obesity and those who were non-smokers (all p&lt;0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy, older Chinese individuals, with an inflection point at 0.68 mg/day and a minimal risk at 0.60–1.00 mg/day of dietary thiamine intake.…”
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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general popu... by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

“…ABSTRACT Aims/Introduction Leukocyte cell‐derived chemotaxin 2 (LECT2) is an obesity‐associated hepatokine that causes skeletal muscle insulin resistance. …”
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Proportion, quality of life and factors associated with perinatal urinary incontinence among pregnant women attending at Muhimbili national hospital by Geofrey P. Chiloleti, Fransia Arda Mushi, Aboud Muhsin, Ally Mwanga

“…A significant association between UI and a normal BMI, pre-obesity [AOR 1.351 95% CI 1.161–1.765], grand multipara [AOR 1.092 95% CI 1.027–1.323], and a previous history of cesarean section [AOR. 5.126 95% CI 2.081–12.628]. …”
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The Age-Specific Association of Waist Circumference and Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus in Shandong, China by Lingling Xu, Weihong Yu, Ping Huang, Chunying Li, Yan Li, Meng Wang, Qun Xu, Jing Wang, Caixia Zheng, Bin Qu, Yanping Zhao, Meng Niu, Ou Wang, Fengying Gong

“…To examine the association of three most common obesity measures including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with chronic kidney disease (CKD) risk in patients with type 2 diabetes mellitus (T2D). …”
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May Measurement Month 2020: An Analysis of Blood Pressure Screening Results From China by Xin Chen, Li‐Ping Zhang, Xiao‐Long Wang, Ning‐Ru Zhang, Jing Yu, Li‐Ying Xu, Tong‐She Li, Hong Luan, Juan Zhang, Ya‐Min Hu, Dan Liu, Qi‐Dong Zheng, Yan Li, Ji‐Guang Wang

“…After adjustment for age, gender, and use of antihypertensive medication, systolic/diastolic BP were significantly higher with cigarette smoking (n = 8070, +0.5/+1.0 mm Hg, p < 0.05), mild (n = 4369, +1.2/+1.3 mm Hg, p < 0.001) and moderate or heavy alcohol drinking (n = 3871, +0.4/+0.7 mm Hg, p < 0.05), and overweight (+1.8/+1.4 mm Hg, p < 0.001) and obesity (+2.3/+1.5 mm Hg, p < 0.001). In conclusion, our study provided unique blood pressure data during the COVID‐19 period, and suggested that hypertension management might have been even more challenging when the medical professionals had to shift their focus on other urgencies.…”
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Predictive role of modifiable factors in stroke: an umbrella review by Yue Wang, Lu Wen, Xiaotong Wang, Man Liang, Fanxin Zeng, Yuetian Yang, Fangfang Nie, Mengke Shang, Na Ta, Lanxin Ou, Zhibin Yang, Wanyang Liu

“…High suggestive evidence mainly included total meat, processes meat, chocolate, sodium, obesity, pulse pressure, systolic blood pressure, diastolic blood pressure, sleep duration and smoking. …”
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Metabolic Phenotyping of Adipose-Derived Stem Cells Reveals a Unique Signature and Intrinsic Differences between Fat Pads by Camille Lefevre, Baptiste Panthu, Danielle Naville, Sylvie Guibert, Claudie Pinteur, Bénédicte Elena-Herrmann, Hubert Vidal, Gilles J. P. Rautureau, Anne Mey

“…While the expansion of subcutaneous adipose tissues (SAT) is protective in obesity, that of visceral adipose tissues (VAT) correlates with the emergence of metabolic diseases. …”
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The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study) by Taiji Hasegawa, Kenji Obayashi, Kimie Miyata, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata, Hiroki Tsujinaka, Mariko Yamashita, Tomo Nishi, Nobuhiro Tone, Naonori Masuda, Yutarou Mizusawa, Masahiro Okamoto, Shinji Maruoka, Masashi Kojima, Toyoaki Matsuura

“…Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. …”
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