Gender Analysis, Milk Value Chain, Kabale Uganda. Kabale: Kabale University. by Tugume, Samuel

“…The few females that owned herds had fewer numbers when compared to the males. Most of the female respondents were involved in pasteurization. …”
Get full text

Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…Material impact on bone formation was assessed in vitro regarding osteoclast/osteoblast numbers and activity. In vivo, drilling defects in a rat- and the 5T33-myeloma mouse model were treated by both materials and assessed by immunohistochemistry, UPLC-MS/MS, µCT, and ToF-SIMS. …”
Get full text

Phenotypic diversity of CTCs and tdEVs in liquid biopsies of tumour-draining veins is linked to poor prognosis in colorectal cancer by Stefan A. Cieslik, Andrés G. Zafra, Christiane Driemel, Monica Sudarsanam, Jan-Philipp Cieslik, Georg Flügen, Levent Dizdar, Andreas Krieg, Sascha Vaghiri, Hany Ashmawy, Stephen Fung, Miriam Wilms, Leon W. M. M. Terstappen, Afroditi Nanou, Hans Neubauer, Nuh N. Rahbari, Wolfram T. Knoefel, Nikolas H. Stoecklein, Rui P. L. Neves

“…Results CTCs and tdEVs were more abundant in the DV samples compared to CVC samples (p < 0.05). tdEVs were detected in higher numbers than CTCs in both compartments. Importantly, tdEVs in CVCs were associated with tumor spread, whereas CTCs in DVs were linked to tumor size. …”
Get full text

First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…Peak persistence was higher in patients who received higher doses.Conclusion In conclusion, IMA202 had a manageable safety profile, and it was associated with biological and potential clinical activity of MAGEA1-targeting genetically engineered TCR-T cells in a poor prognosis, multi-indication solid tumor cohort.Trial registration numbers NCT04639245, NCT05430555.…”
Get full text

The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Citral supplementation significantly improved intestinal morphology, with goblet cell numbers, mucosal thickness, and villus-to-crypt ratios peaking at 2–4 mL/kg (P < 0.05). …”
Get full text

Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Background &amp; Aims: Radiofrequency ablation (RFA) is the standard treatment for small hepatocellular carcinoma (HCC), specifically for tumors <3 cm in size and numbering fewer than three, excluding surgical candidates. …”
Get full text

Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…CyTOF indicated that the bone marrow (BM) of both models was inflamed, suggesting that immune suppressive cells might be inhibiting the reactivation of T cells in the BM. We observed higher numbers of MDSCs, regulatory T (Treg) cells, and tumor-associated macrophage (TAMs) in myeloma BM compared with that of tumor-free mice. …”
Get full text

Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…Promoter activity assays showed that the transcriptional repressor RstR protected against CTXΦ superinfection by preventing the replication and integration of CTXΦ/pre-CTXΦ phages containing the same <i>rstR</i> allele, supporting the co-integration of the diverse CTXΦ/pre-CTXΦ members observed. The numbers and types of prophages and their co-integration arrangements in serogroup O139 strains were more complex than those in serogroup O1 strains. …”
Get full text

Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…IRs remained consistent with previous reports from the tofacitinib RA clinical development programme, and stable over time.Trial registration numbers NCT01262118; NCT01484561; NCT00147498; NCT00413660; NCT00550446; NCT00603512; NCT00687193; NCT01164579; NCT00976599; NCT01059864; NCT01359150; NCT02147587; NCT00960440; NCT00847613; NCT00814307; NCT00856544; NCT00853385; NCT01039688; NCT02187055; NCT00413699; NCT00661661.For summary of phase I, phase II, phase III, phase IIIb/IV and LTE studies included in the integrated safety analysis, see online supplemental table 1.…”
Get full text

Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…Trial Registration The supplementary Table S1 provides a comprehensive list of clinical trials and their registration numbers.…”
Get full text

Yeast cell wall polysaccharides accelerate yet in-feed antibiotic delays intestinal development and maturation via modulating gut microbiome in chickens by Fangshen Guo, Jianing Qiao, Zeqiong Hu, Jia Huang, Ruichen Bi, Waseem Abbas, Wenrui Zhen, Yuming Guo, Zhong Wang

“…Nevertheless, dietary YCWP addition significantly increased the ratio of villus height to crypt depth (d 21), villus surface area (d 21 and d 42), ileal alkaline phosphatase and maltase activities as well as goblet cell (d 21 and d 42) and IgA-producing plasma cell numbers as compared to BMD treatment (d 21, P < 0.05). …”
Get full text

Selective dry cow therapy: Clinical field trial on prevention and cure of intramammary infections by R.E. Niemi, M. Hovinen, P.J. Rajala-Schultz

“…Based on odd or even identification numbers, cows with an SCC between 100,000 and 250,000 cells/mL were sequentially assigned to either receive DCT at dry-off (DCT100–250) or remain untreated (NoDCT100–250). …”
Get full text

La question du logement social à New York by Catherine Pouzoulet

“…At the same time, New York City had become sadly famous for housing unrivalled numbers of its working‑class and immigrants in unhealthy, dilapidated tenements. …”
Get full text

Effect of Scalp-acupuncture Treatment on Language Reorganization in Poststroke Aphasia：A Functional Near-Infrared Spectroscopy by LIN Bingbing, NI Jinglei, XIONG Xiao, HUANG Yunshi, HUANG Jia

“…Methods A total of 64 PSA patients hospitalized in the Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine from July 2022 to September 2023 were selected，and a table of random numbers was generated using SAS 9. 1 statistical software，and each group was divided into a control group and an observation group according to a 1：1 ratio，with 32 cases in each group. …”
Get full text

Kombinasi K-Means dan Support Vector Machine (SVM) untuk Memprediksi Unsur Sara pada Tweet by Wiga Maulana Baihaqi, Muliasari Pinilih, Miftakhul Rohmah

“…Abstract Posts sent via twitter are called tweets or in Indonesian better known as chirping, the posts shared have a maximum limit, the writing cannot be more than 140 characters, the characters here consist of letters, numbers, and symbols. Broadcasting in discussions that often occur on social media, often users of social media consciously or unconsciously have created content that contains issues of ethnicity, religion, race (nationality) and intergroup (SARA). …”
Get full text

Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…Though the hyper ammonia-producing bacteria (HAB) are present inside the rumen (Clostridium aminophilum, Peptostreptococcus anaerobius, and Clostridium sticklandii) in low numbers, the concentration of ammonia (>300 nmol NH3/ mg cell protein/ min) they can produce makes them quantitatively important. …”
Get full text

Magnetocaloric Effect for a <i>Q</i>-Clock-Type System by Michel Aguilera, Sergio Pino-Alarcón, Francisco J. Peña, Eugenio E. Vogel, Natalia Cortés, Patricio Vargas

“…We calculate the thermodynamic quantities using Monte Carlo simulations for even <i>Q</i> numbers, ranging from <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>2</mn></mrow></semantics></math></inline-formula> to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>8</mn></mrow></semantics></math></inline-formula> spin orientations per site in a lattice. …”
Get full text

Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Chunfang Zhao, Erhui Jin, Erhui Jin, Youfang Gu, Youfang Gu, Hongyu Wang, Feng Zhang, Feng Zhang

“…Berberine increased jejunal villus height, villus/crypt ratio, mucosal thickness (P &lt; 0.05), and goblet cell numbers in the villi and crypts (P &lt; 0.05). Furthermore, berberine increased the optical density of mucin 2 and the mucin 2, P-glycoprotein, and CYP3A4 mRNA expression levels (P &lt; 0.05). …”
Get full text

L’africanisation de l’Église évangélique au Maroc : revitalisation d’une institution religieuse et dynamiques d’individualisation by Bernard Coyault

“…Attended first by Europeans only, its numbers had inexorably declined from Morocco’s independence in 1956 until the nineties. …”
Get full text

On Discrete Shifts of Some Beurling Zeta Functions by Antanas Laurinčikas, Darius Šiaučiūnas

“…We consider the Beurling zeta function <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>ζ</mi><mi mathvariant="double-struck">P</mi></msub><mrow><mo>(</mo><mi>s</mi><mo>)</mo></mrow></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>s</mi><mo>=</mo><mi>σ</mi><mo>+</mo><mi>i</mi><mi>t</mi></mrow></semantics></math></inline-formula>, of the system of generalized prime numbers <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="double-struck">P</mi></semantics></math></inline-formula> with generalized integers <i>m</i> satisfying the condition <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mo>∑</mo><mrow><mi>m</mi><mo>⩽</mo><mi>x</mi></mrow></msub><mn>1</mn><mo>=</mo><mi>a</mi><mi>x</mi><mo>+</mo><mi>O</mi><mrow><mo>(</mo><msup><mi>x</mi><mi>δ</mi></msup><mo>)</mo></mrow></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>a</mi><mo>></mo><mn>0</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0</mn><mo>⩽</mo><mi>δ</mi><mo><</mo><mn>1</mn></mrow></semantics></math></inline-formula>, and suppose that <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>ζ</mi><mi mathvariant="double-struck">P</mi></msub><mrow><mo>(</mo><mi>s</mi><mo>)</mo></mrow></mrow></semantics></math></inline-formula> has a bounded mean square for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>σ</mi><mo>></mo><msub><mi>σ</mi><mi mathvariant="double-struck">P</mi></msub></mrow></semantics></math></inline-formula> with some <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>σ</mi><mi mathvariant="double-struck">P</mi></msub><mo><</mo><mn>1</mn></mrow></semantics></math></inline-formula>. …”
Get full text