Ovarian cancer prevention through opportunistic salpingectomy during abdominal surgeries: A cost-effectiveness modeling study. by Angela Kather, Habib Arefian, Claus Schneider, Michael Hartmann, Ingo B Runnebaum

“…<h4>Methods and findings</h4>A state transition model representing all relevant health states (healthy, healthy with hysterectomy or tubal ligation, healthy with other gynecologic or non-gynecologic abdominal surgery, healthy with hysterectomy and salpingectomy, healthy with salpingectomy, healthy with hysterectomy and salpingo-oophorectomy, ovarian cancer and death) was developed and informed with transition probabilities based on inpatient case numbers in Germany (2019). Outcomes for women aged 20-85 years were simulated over annual cycles with 1,200,000 million individuals. …”
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Application of Minimally Invasive Oral Swab Samples for qPCR-Based Sexing in Neognathae Birds by Maria-Carmen Turcu, Anamaria Ioana Paștiu, Lucia-Victoria Bel, Anca-Alexandra Doboși, Dana Liana Pusta

“…This qPCR method assesses variations in gene copy numbers within conserved Z-specific genes such as <i>CHRNA6</i>, <i>DDX4</i>, <i>VPS13A</i>, <i>LPAR1</i>, and <i>TMEM161B</i>, which are absent from the W chromosome. …”
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Quantification of ecosystem services from mangrove silvofishery by E. Sumarga, D. Rosleine, G.B. Hutajulu, R.P. Plaurint, Tsabita ., M. Basyuni, S.H. Larekeng, M.F. Taqiyudin, N.N. Shohihah, H. Ali

“…The natural beauty of the Blanakan mangrove area attracts tourists with its diverse ecosystem and opportunities to see crocodile breeding facilities. Visitor numbers vary, averaging around 128 people per month until mid-2023. …”
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Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1–3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry by Antonio Di Muzio, Corrado Angelini, Tiziana Mongini, Liliana Vercelli, Lucia Morandi, Giovanni Antonini, Gabriele Siciliano, Lucio Santoro, Maurizio Moggio, Giacomo Brisca, Luisa Villa, Giuliano Tomelleri, Francesco Sera, Carmelo Rodolico, Lorenzo Maggi, Giulia Ricci, Angela Berardinelli, Elena Pegoraro, Sabrina Ravaglia, Chiara Fiorillo, Michelangelo Cao, Rossella Tupler, Ana Nikolic, Elisabetta Bucci, Monica Govi, Fabiano Mele, Marta Rossi, Lucia Ruggiero, Maria Chiara D'Amico, Maria Grazia D'Angelo, Claudio Bruno

“…Objectives Facioscapulohumeral muscular dystrophy type 1 (FSHD1) has been genetically linked to reduced numbers (≤8) of D4Z4 repeats at 4q35. Particularly severe FSHD cases, characterised by an infantile onset and presence of additional extra-muscular features, have been associated with the shortest D4Z4 reduced alleles with 1–3 repeats (1–3 DRA). …”
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Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury by Kurt T. K. Giuliani, Purba Nag, Benjamin C. Adams, Xiangju Wang, Seokchan Hong, Anca Grivei, Rebecca L. Johnston, Nicola Waddell, Kenneth K. C. Ho, Yilin Tian, Muhammad Ali Khan, Chang Seong Kim, Monica S. Y. Ng, Glenda Gobe, Jacobus P. J. Ungerer, Josephine M. Forbes, Helen G. Healy, Andrew J. Kassianos

“…In vitro findings were validated in human CKD bio-specimens (kidney tissue, urine), with elevated PTEC IL-1RI expression and senescence (SA-β-gal activity) detected in fibrotic kidneys and numbers of senescent (SA-β-gal+) urinary PTECs correlating with urinary IL-1β levels and severity of interstitial fibrosis. …”
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Identification of Southeast Asian Anopheles mosquito species with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a cross-correlation approach by Victor Chaumeau, Sunisa Sawasdichai, Thu Zar Ma Ma Moe Min, Thithiwarada Kularbkeeree, Naw Jaruwan, Naw Gloria, Naw Yu Lee, Muesuwa Trackoolchengkaew, Monticha Phanaphadungtham, Patcharamai Rongthong, Aritsara Inta, Wanitda Watthanaworawit, François Nosten

“…A simulation experiment was carried out by querying the reference database with the spectra of the test panel to evaluate the performance of species identification with MALDI–TOF MS at varying thresholds of the cross-correlation index for the algorithm to output an identification result and with varying numbers of technical replicates for the tested specimens, considering PCR identification results as the reference. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…Successful ACT relies on ex vivo expansion of large numbers of desired T-cells with strong cytotoxic capacity and in vivo persistence, which constitutes the greatest challenge to current ACT strategies. …”
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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

“…Given costs and prevalence of dehydration in older people we suggest use of the best formula by pathology laboratories using a cutpoint of 295 mOsm/L (sensitivity 85%, specificity 59%), to report dehydration risk opportunistically when serum glucose, urea and electrolytes are measured for other reasons in older adults.Trial registration numbers: DRIE: Research Register for Social Care, 122273; NU-AGE: ClinicalTrials.gov NCT01754012.…”
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Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibiti... by Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo, Saifei Hu, Yanni He, Yingnan Wang, Yao Chen, Youqiang Su, Congxiu Miao, Yun Qian, Ruizhi Feng

“…The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained. Methods Using microinjection mRNA and genome engineering to reintroduce the conserved pathogenic missense variants into oocytes or in generating TUBB8 variant knock‐in mouse models, we investigated that the human deleterious variants alter microtubule nucleation and spindle assembly during meiosis. …”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…These identified species have been deposited in GenBank™ under the accession numbers OM817461 (C. parvum FSA-1), OM817462 (C. parvum FSA-2), and OM817463 (C. parvum FSA-3) and revealed closed genetic identity with those species reported from human and other animal species in the same geographic location.ConclusionOverall, this study represents the first morphological and genetic identification of C. parvum isolated from fecal samples of fat sand rats trapped from periurban areas in Egypt. …”
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Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled... by Juliet Nabbuye Sekandi, Esther Buregyeya, Sarah Zalwango, Damalie Nakkonde, Patrick Kaggwa, Trang Ho Thu Quach, David Asiimwe, Lynn Atuyambe, Kevin Dobbin

“…Each group was further stratified to ensure equal numbers of males and females. Eligible patients were aged 18-65 years, had a confirmed diagnosis of TB, and were undergoing daily treatment. …”
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Investigation of Moral Literacy Levels of University Students (The Case of Mus Alparslan University) by Fatma BİLDİRİCİ, Teceli KARASU

“…Before the research, the ethics committee approval dated 10.05.2024 and numbered 141173 was obtained from Muş Alparslan University Scientific Research and Publication Ethics Committee. …”
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Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

“…In Scenario 3, it was assumed that the absolute numbers of years of life lost (YLL) and years lived with disability (YLD) in 2030 would remain unchanged from the 2020 levels. …”
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Pengembangan Jadwal Shift Staf Editor Video pada Stasiun Televisi Nasional Trans7 berbasis Android menggunakan Algoritma Ant Colony dengan Firebase by Rizal Rizal, Eliyani Eliyani

“…The suitable algorithm to generate a schedule quickly in large numbers with no data clashing is ant colony.Ant colony algorithm refers to the way of ants when looking for food in a group, then they can return again to their original place with the same path and fast. …”
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Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics by Kapish Gupta, Jessica Llewellyn, Emilia Roberts, Chengyang Liu, Ali Naji, Richard K. Assoian, Rebecca G. Wells

“…We showed that neonatal EHBDs as well as mice heterozygous for Efemp1 have decreased numbers of elastic fibers, and that this alters EHBD mechanics. …”
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Assessment of post-partum physical exercise practice and its associated factors among women in postpartum period, in West Wollega zone, Oromia, Ethiopia by Tegegne Yadeta, Daniel Belema, Seifedin Ahmad, Nurye Sirage, Abubeker Seid Ali, Kedir Ali, Ali Yimer

“…A sample of 422 women was chosen through a simple random sampling method utilizing computer-generated random numbers. The data was inputted into Epi-Data 4.6 and processed with SPSS 26. …”
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Determinants of Parental Attitudes towards Children’s Vaccination in Lithuania: An Online Survey by Kamilė Čeponytė, Eglė Narkevičiūtė, Aušra Beržanskytė, Sigita Burokienė

“… Background: Data from recent years show that the COVID-19 pandemic has significantly reduced the scope of child immunisation worldwide. If the numbers continue to fall, we may have a vaccination crisis. …”
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Syphilis reactivity among blood donors in Brazil: associated factors and implications for public health monitoring by Natalia A. Braga, Sheila de Oliveira Garcia Mateos, Renata Buccheri, Vivian I. Avelino-Silva, Donald E. Warden, Cesar de Almeida-Neto, Maisa Ribeiro, Luiz Amorim, Paula Loureiro, Nelson Fraiji, Marcio K. Oikawa, Eduard Grebe, Mars Stone, Ester C. Sabino, Brian Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)

“…Blood donors had lower rates of syphilis compared to the general population, with correspondence between numbers in blood donors and congenital syphilis rates registered by the Brazilian surveillance system between 2012 and 2022. …”
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Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat by Shellye González-González, Mariana Gutiérrez-Pérez, Mara A. Guzmán-Ruiz, Estefania Espitia-Bautista, Rosa María Pavón, Karla P. Estrada-Rodríguez, Alejandro Díaz-Infante R., Cecilia G. Guadarrama Gándara, Carolina Escobar, Natalí N. Guerrero-Vargas

“…In contrast, DLAN male offspring exhibited a significant decrease in social play behavior compared to LD animals, which was associated with higher numbers of microglia in the NAc that had more ramified morphology. …”
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Sustainable healthy settlement on a small island as a cultural heritage area by I. Martias, R. Rifardi, A. Agrina, I. Suprayogi

“…Several attributes significantly influenced the sustainability of healthy settlement arrangements in the coastal area of Penyengat Island, including household waste management, lighting in houses, noise levels, residential density, clean water supply, corporate social responsibility (CSR) funding, occupation, income growth, technological innovation, tourist numbers, public perception of the distance between cultural heritage and settlements, social conflicts, implementation of mutual cooperation, community group management, handling cross-program problems, education and training, settlement regulations, community organization regarding settlements, socialization of regulations, cultural heritage organizations, hedgerows, additional vegetation, tree canopy expansion, and rain gardens. …”
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