THE NORTHERN TERRITORIES OF WESTERN SIBERIA: DEMOGRAPHIC TRENDS AND GROWTH PARADOXES by Andrei G. Shelomentsev, Vladimir M. Kurikov, Kseniya S. Goncharova, Alina V. Istratii

“…The findings highlight the need for further comprehensive analysis of socio-demographic trends, with particular attention to permanent residents, indigenous small-numbered peoples of the North, and populations engaged in shift work. …”

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation by Nagarajan Selvamurugan, Zhiming He, Daniel Rifkin, Branka Dabovic, Nicola C. Partridge

“…PEMF stimulation of hBMSCs’ cell numbers mainly affected genes of cell cycle regulation, cell structure, and growth receptors or kinase pathways. …”
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GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome by Laetitia Largeaud, Vincent Fregona, Laura A. Jamrog, Camille Hamelle, Stéphanie Dufrechou, Naïs Prade, Esmaa Sellam, Pauline Enfedaque, Manon Bayet, Sylvie Hébrard, Mathieu Bouttier, Christine Didier, Bastien Gerby, Eric Delabesse, Marlène Pasquet, Cyril Broccardo

“…These include increased LT-HSC numbers, reduced self-renewal potential, and impaired response to acute inflammatory stimuli. …”
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Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice by Yong Xie, Hongliang Zeng, Zhiji Huang, Hui Xu, Qunyan Fan, Yi Zhang, Baodong Zheng

“…Moreover, BDNF levels for CA1, CA2, and CA3 regions in hippocampi and the numbers of dyed neurons in CA1, CA2, CA3, and DG regions among the offspring were significantly enhanced due to the intake of EBN by the maternal mice. …”
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Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites by Brian J. Parrett, Satoko Yamaoka, Michael A. Barry

“…Here, we use a luciferase reporter system to compare different copy numbers and insertion locations of miR-122 binding sequences to restrict liver expression. …”
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In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications by Guoguang Niu, John P. McQuilling, Yu Zhou, Emmanuel C. Opara, Giuseppe Orlando, Shay Soker

“…Dissociated islet cells that are cultured in cell numbers by in vitro proliferation provide a promising platform for redifferentiation towards β-cells phenotype. …”
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Flexible Work: Opportunity and Challenge (FLOC) for individual, social and economic sustainability. Protocol for a prospective cohort study of non-standard employment and flexible... by Gunnar Bergstrom, David M Hallman, Marina Heiden, Sven Svensson, SvendErik Mathiassen, Arne Fagerström, Jean Claude Mutiganda

“…The analyses will take into account that respondents are nested in organisations, divisions and/or have specific managers.Ethics and dissemination FLOC is approved by the Swedish Ethical Review Authority (decision numbers 2019–06220, 2020–06094 and 2021–02725). Data will be published in peer-reviewed journals and presented at international conferences, and researchers will assist the organisations in improving policies and routines for employment and organisation of work.…”
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Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice by Xiaoxie Xu, Jun Huang, Mei Zhao, Huanpeng Chen, Jinhua Mo, Xiaoqing Zhou, Qiao Su, Bolan Yu, Zhaofeng Huang

“…Meanwhile, stabilized β-catenin obviously decreased the numbers of spleen TCRβ+CD4−CD8− T (DNT) cells, and the levels of some serum proinflammatory factors also were lowered in β-catTglpr/lpr mice. …”
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Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice by Ana Paula M. S. Brandão, Fernanda S. Oliveira, Natalia B. Carvalho, Leda Q. Vieira, Vasco Azevedo, Gilson C. Macedo, Sergio C. Oliveira

“…At 1 week after infection, IFN-γ KO and IL-12/β2-m KO mice showed increased numbers of bacterial load in spleens; however, at 3 weeks postinfection (p.i.), only IFN-γ KO succumbed to Brucella. …”
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Novel Multicriteria Decision Making Approach for Interactive Aggregation Operators of q-Rung Orthopair Fuzzy Soft Set by Rana Muhammad Zulqarnain, Imran Siddique, Aiyared Iampan, Jan Awrejcewicz, Maksymilian Bednarek, Rifaqat Ali, Muhammad Asif

“…Considering the interaction, this paper will develop some novel operational laws for q- rung orthopair fuzzy soft numbers (q-ROFSNs). Some aggregation operators (AOs) such as q-rung orthopair fuzzy soft interactive weighted average (q-ROFSIWA) and q-rung orthopair fuzzy soft interactive weighted geometric (q-ROFSIWG) operators have been introduced. …”
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Adherence to clinical practice guidelines on community acquired pneumonia and its relation to mortality rates. by María Caridad Fragoso Marchante, Alfredo Darío Espinosa Brito, Gustavo Álvarez Amador, Iris González Morales, José Luis Bernal Muñoz, Miguel Mosquera Fernández

“…<br /><strong>Results</strong>: The results are presented in tables of numbers and percent. Variables independently associated with mortality were: age (over 65 years old people), radiological lesions in more than one lobe or bilateral, atypical pneumonia debut, negative assessments as to the adherence to guidelines and inadequate treatments. …”
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Cost-utility analysis of combination medical therapies in chronic coronary syndrome: a comparative study using real-world and patient-level data from Iran by Fatemeh Soleymani, Parham Sadeghipour, Majid Davari, Abbas Kebriaeezadeh, Behzad Fatemi, Mohammad Reza Maracy, Nasim Naderi, Saman Zartab

“…Objectives The main objective was to evaluate the cost-effectiveness of various medical therapy combinations in managing chronic coronary syndrome (CCS) in Iran, based on real-world and patient-level data.Design A cost-utility analysis employing a Markov model was conducted using data from a retrospective cohort study.Setting The study was conducted in the healthcare setting of Iran, focusing on primary and secondary care.Participants Patients with CCS were included in the study. Numbers entering and completing the study were reported, with clear definitions of selection, entry and exclusion criteria.Interventions All combinations of recommended medical therapies for CCS were permitted. …”
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Clinico-epidemiological characteristics of patients reported with intra-hospital infection in the Pediatric Intensive Care Unit. Cienfuegos, 2015-2019 by Lourdes Elena Duany Badell, Sadis Suárez del Villar Seuret, Tania Cantero Martínez, Maribel Caridad Águila Toledo, Sarah Hernández Malpica, Vivian Hernández Monsón

“…<br /><strong>Conclusions:</strong> the nosocomial infection rate is comparable with the numbers reported internationally. Children under one year of age are more infected, with a non-negligible lethality, so prevention and control measures aimed at the main risk factors for their appearance must be taken to extremes.…”
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Fas Ligand DNA Enhances a Vaccination Effect by Coadministered DNA Encoding a Tumor Antigen through Augmenting Production of Antibody against the Tumor Antigen by Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

“…We did not detect increased numbers of β-gal-specific CD8+ T cells in lymph node of mice that received combination of β-gal and FasL DNA, but amounts of anti-β-gal antibody increased with the combination but not with β-gal or FasL DNA injection alone. …”
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SensorDBSCAN: Semi-Supervised Active Learning Powered Method for Anomaly Detection and Diagnosis by Petr Ivanov, Maria Shtark, Alexander Kozhevnikov, Maksim Golyadkin, Dmitry Botov, Ilya Makarov

“…Unlike existing methods, SensorDBSCAN eliminates the need for manual labeling large amounts of data, cluster analysis, and pre-defining cluster numbers, providing greater usability in real-world cases. …”
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Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism by Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He

“…The results showed that tryptase induced up to 6.7-fold increase in mast cell numbers in mouse peritoneum following injection. Inhibitors of tryptase, an antagonist of PAR-2 FSLLRY-NH2, and pretreatment of mice with anti-ICAM-1, anti-CD11a, and anti-CD18 antibodies dramatically diminished tryptase induced mast cell accumulation. …”
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The Clock Drawing Task reveals executive dysfunction in the dialysis population – an underrecognized and underestimated problem by Piotr Olejnik, Aleksandra Golenia, Oliwia Maciejewska, Ewa Wojtaszek, Paweł Żebrowski, Jolanta Małyszko

“…Moreover, remarkably similar pattern of clock drawing was observed, with numbers written outside the clock face in the CLOX1 test.Conclusions Executive dysfunctions in dialysis patients may manifest itself before the onset of global cognitive impairment. …”
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The role of wetland birds in biocultural conservation: analysing global discourses and practices on species and ecosystems by Paola Araneda, Peter Bridgewater, José Cristóbal Pizarro, José Tomás Ibarra

“…The publications spanned 96 countries, with Mexico, the United States, and India having the highest numbers of studies. This is consistent with the ethnobotanical research tradition from the dominant anthropological discourse. …”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

“…Results showed that co-exposure to PS-NPs and Cd exacerbated ovarian toxicity in rats, primarily through increased atretic follicle numbers and endocrine disruption. Further studies revealed that PS-NPs and Cd synergistically repressed the SIRT3-SOD2/Gpx4 pathway, inducing mitochondrial oxidative stress and ferroptosis, resulting in damage to ovarian structure and function. …”
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Assessment of grazing livestock balance on the Eastern Mongolian Plateau based on remote sensing monitoring and grassland carrying capacity evaluation by Menghan Li, Juanle Wang, Kai Li, Yaping Liu, Altansukh Ochir, Davaadorj Davaasuren

“…However, the overall grassland carrying condition has gradually deteriorated, primarily due to factors such as grassland fires and an increase in livestock numbers. Based on the varying degrees of grassland degradation, different policy recommendations have been proposed. …”
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