An Overview of Solar Orbiter Observations of Interplanetary Shocks in Solar Cycle 25 by Domenico Trotta, Andrew Dimmock, Heli Hietala, Xochitl Blanco-Cano, Timothy S. Horbury, Rami Vainio, Nina Dresing, Immanuel Christopher Jebaraj, Francisco Espinosa Lara, Raúl Gómez-Herrero, Javier Rodriguez-Pacheco, Yulia Kartavykh, David Lario, Jan Gieseler, Miho Janvier, Milan Maksimovic, Nasrin Talebpour Sheshvan, Christopher J. Owen, Emilia K. J. Kilpua, Robert F. Wimmer-Schweingruber

“…The fundamental shock parameters (shock normals, shock normal angles, shock speeds, compression ratios, Mach numbers) have been estimated and studied as a function of heliocentric distance, revealing a rich scenario of configurations. …”
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Income level is associated with differences in primary and secondary stroke prevention in China by Huiming Ren, Junrong Ma, Xu Guo, Ruijie Zhang, Liyuan Pu, Tian Zhao, Fangfang Zeng, Chang Shu, Liyuan Han, Yunzhi Wang, Qiang Li, Xiaojie Wang

“…Stroke was determined by the self-reporting of a doctor’s diagnosis, and participants with a high risk of stroke were identified using the model developed in the Prediction for ASCVD Risk in China study. Results The final numbers of people included in this study were 8,884 with stroke and 218,972 with a high risk of stroke. …”
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Evaluation of the efficacy of low concentration fluoride gel using custom trays to prevent radiation-related dental caries in patients with head and neck cancer: protocol for a ran... by Yumiko Kawashita, Masahiro Umeda, Toshiyuki Saito, Sakiko Soutome, Souichi Yanamoto, Maho Murata, Masako Yoshimatsu, Madoka Funahara

“…The datasets generated during the current study will be available from the corresponding author on reasonable request.Trial registration numbers jRCTs 072190039 and UMIN000041426…”
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Characterization and Comparative Analysis of RWP-RK Proteins from Arachis duranensis, Arachis ipaensis, and Arachis hypogaea by Chenyang Liu, Dongliang Yuan, Tong Liu, Mengge Xing, Wenying Xu, Huiying Zhang, Hanqi Jin, Chunmei Cai, Shuai Li

“…One, one, and seventeen duplicated gene pairs were identified within the A. duranensis, A. ipaensis, and A. hypogaea genomes, respectively. Moreover, different numbers of cis-acting elements in the RWP-RK promoters were found in wild and cultivated species (87 in A. duranensis, 89 in A. ipaensis, and 92 in A. hypogaea), and as a result, many RWP-RK genes showed distinct expression patterns in different tissues. …”
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Differentiation and Molecular Properties of Mesenchymal Stem Cells Derived from Murine Induced Pluripotent Stem Cells Derived on Gelatin or Collagen by Chizuka Obara, Kazuya Takizawa, Kenichi Tomiyama, Masaharu Hazawa, Ai Saotome-Nakamura, Takaya Gotoh, Takeshi Yasuda, Katsushi Tajima

“…The cells were derived by a one-step method and expressed CD73 and CD90, but CD105 was downregulated in iMSCs cultured only on gelatin-coated plates with increasing numbers of passages. A pairwise scatter analysis revealed similar expression of MSC-specific genes in iMSCs derived on gelatin and on collagen surfaces as well as in primary mouse bone marrow MSCs. …”
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In Situ Aqueous Spice Extract-Based Antifungal Lock Strategy for Salvage of Foley’s Catheter Biofouled with <i>Candida albicans</i> Biofilm Gel by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Kalidas Shetty, Adithya Rathish, Harshala Shivkumar, Malavika Gundreddy, Nikhil Kumar Kagganti Narendra, Nethra Machamada Devaiah

“…SEM revealed a switch from the biofilm to the yeast mode and a drastic reduction in cell numbers, with mostly clumped or lysed cells. The study will provide an impetus to the development of novel spice extract-based ALT, reducing the selection pressure on the pathogen and lowering antimicrobial resistance. …”
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CircRNA-Disease Associations Prediction Based on Metapath2vec++ and Matrix Factorization by Yuchen Zhang, Xiujuan Lei, Zengqiang Fang, Yi Pan

“…Evidence has shown that circRNAs are related to many biological processes and play essential roles in different biological functions. Although increasing numbers of circRNAs are discovered using high-throughput sequencing technologies, these techniques are still time-consuming and costly. …”
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Clinical characteristics of pediatric patients with SARS-CoV-2 infection. Cienfuegos, 2020-2021 by Mercedes Fonseca Hernández, Dunia María Chávez Amaro, Vivian Isabel Chávez Pérez, Julio Héctor Jova Dueñas, Tamara L. Jiménez Sáez, Ifrain Machín Caride

“…<p><strong>Background:</strong> the significant increase in the numbers of COVID-19 patients in Cuba and the increasing incidence rate in the pediatric age represent an emerging health problem.…”
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Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking by Hyo Kyung Lee, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, Joo Youn Oh

“…There were no differences in corneal thickness and epithelial healing between the groups. The numbers of BrdU-labelled and p63+ limbal epithelial cells were markedly reduced in the group without a ring, but significantly increased when a ring was used. …”
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IMPACT OF COVID-19 ON HAND AND WRIST ORTHOPEDIC SURGERIES IN A PRIVATE SERVICE by Erick Yoshio Wataya, Katherine Vanessa Tenezaca Rodriguez, Lucas Sousa Macedo, Ricardo Boso Escudero, Luiz Sorrenti, Bernardo Figueira Althoff, Ana Katherina Abarca Herrera, Maurício Pinto Rodrigues, Antonio Carlos da Costa, Mateus Saito, João Carlos Nakamoto

“…The total surgeries were computed and separated into elective or emergency surgeries. The numbers were analyzed by month, quarter, and year before and after the pandemic (March 2020). …”
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Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…The resistance to four antibiotics, including last resort drugs, was significantly reduced by individual and multi-gene targeting of ARGs in low- to high-copy numbers in recombinant E. coli. Escaper analysis confirmed the absence of mutations in target sequence, corroborating the harmless role of CRISPRi in the selection of new resistances. …”
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Morphometric Changes in Patients with Chronic Kidney Disease who Died Related to Diabetes Mellitus, Arterial Hypertension and Obesity by Ivette Gómez Fernández, Adys Castro Barberena, Greta Margarita Arrechea García, Georgina Jiménez Estrada, Javier Martínez Navarro, Domingo Fuentes Febles

“…The data was processed in the statistical package of SSPS v. 11.5 presenting tables in absolute numbers and percentages. <strong><br />Results:</strong> the female sex predominated, aged between 70-79 years, with clinical stage I and IV of chronic kidney disease, the obese represented 57.6 %, the hypertensive 67.1 % and the diabetic 25.8 %. …”
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Foliar spraying melatonin reduces the threat of chromium-contaminated water to wheat production by improving photosynthesis, limiting Cr translocation and reducing oxidative stress by Chuanjiao Sun, Libing Xu, Qiang Gao, Shuzhen Sun, Xiaoxue Liu, Zigang Zhang, Zhongwei Tian, Tingbo Dai, Jianyun Sun

“…Our results showed that Cr-contaminated water irrigation significantly reduced dry weight, grain numbers, grain weight, yield, harvest index, net photosynthetic rate (Pn), maximum and actual photochemical efficiency of photosystem II (Fv/Fm and ΦPSII), chlorophyll contents, and the a/b ratio. …”
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Application of a targeted amplicon sequencing panel to screen for insecticide resistance mutations in Anopheles darlingi populations from Brazil by Holly Acford-Palmer, Alice O. Andrade, Jody E. Phelan, Rosa A. Santana, Stefanie C. P. Lopes, Jansen F. Medeiros, Taane G. Clark, Maisa S. Araujo, Susana Campino

“…When used in tandem with dual-index barcoding of amplicons, this approach permits high numbers of loci and samples to be sequenced in single runs, thereby decreasing costs and increasing efficiency. …”
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Federated Digital Twins: A Scheduling Approach Based on Temporal Graph Neural Network and Deep Reinforcement Learning by Young-Jin Kim, Hanjin Kim, Beomsu Ha, Won-Tae Kim

“…Furthermore, even in untrained scenarios with increasing numbers of fDTs and DTs, it outperforms baseline algorithms on both metrics, confirming its scalability.…”
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DNA origami-designed 3D phononic crystals by Park Sung Hun, Park Haedong, Nam Jwa-Min, Ke Yonggang, Liedl Tim, Tian Ye, Lee Seungwoo

“…Furthermore, their lattice symmetry can be molecularly programmed to be at the highest level in a hierarchy of symmetry groups and numbers, which can facilitate the widening of the PnBG. …”
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A comprehensive global mapping of offshore lighting by C. D. Elvidge, T. Ghosh, N. Chatterjee, N. Chatterjee, M. Zhizhin, M. Zhizhin, P. C. Sutton, M. Bazilian

“…., fishing grounds, platforms, anchorages, gas flares, transit routes, and the glow surrounding bright lighting onshore. The richness of the numbers and types of offshore lighting structures can be traced back to the DNB spike detector at the core of the VBD algorithm. …”
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Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

“…We will submit the results for publication in a peer-reviewed journal.Trial registration numbers ISRCTN—ISRCTN44351742 and ClinicalTrials.gov—NCT02040272.…”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…Upregulated GRID1 mediates signal transmission in neural pathways, restores the regenerative ability of hippocampal nerve cells, promotes nerve growth and synaptic formation, increases synapse numbers, and enhances synaptic function. Our findings highlight the therapeutic potential of targeting HDAC5 in depression and clarify the antidepressant mechanism of T2943.…”
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Multiscale Feature-Enhanced Water Body Detector of Truncated Gaussian Clutter in SAR Imagery by Bo Zhu, Yuli Xia, Yongsheng Zhou, Xiaoning Lv, Minqin Liu

“…Furthermore, shadows in SAR imagery have similar digital numbers and statistical parameters to water, making them difficult to distinguish. …”
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