Inflammasome Genes’ Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment by Shady Z. K. Estfanous, Sahar A. Ali, Sameh M. Seif, Sameh H. A. Soror, Dalia H. A. Abdelaziz

“…The aim of our study was to investigate the association of nine single-nucleotide polymorphisms in four inflammasome genes (NLRP3, CARD8, IL-1β, and IL-18) with the susceptibility to HCV infection and outcome of interferon treatment in 201 Egyptian chronic hepatitis C patients and 95 healthy controls. …”
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The complete mitochondrial genome of Gyrodactylus pseudorasborae (Platyhelminthes: Monogenea) with a phylogeny of Gyrodactylidae parasites by Xinyi Zeng, Ye Li, Yang Liu, Yaoying Chen, Yajing Liu, Mengwei Song, Tao Chen

“…The mitogenome of G. pseudorasborae presents a clear bias in nucleotide composition with a negative AT skew and a positive GC skew except for NCR. …”
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Evaluation of current gene pool of Kholmogor and Black-and-white cattle breeds based on whole genome SNP analysis by A. V. Dotsev, A. A. Sermyagin, A. V. Shakhin, I. A.  Paronyan, K. V. Plemyashov, H. Reyer, K. Wimmers, G. Brem, N. A. Zinovieva

“…The aforementioned breeds were studied using their whole-genome single nucleotide polymorphism (SNP) genotypes. The Kholmogor breed was subdivided into three groups: purebred (KHLM, n = 3), admixed with Holsteins (KHLM-HLST, n = 4) and representatives of old-type breed (KHLM-INTA, n = 15). …”
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Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0... by Alena S. Ovchinnikova, Dmitrii A. Odnoshevsky, Alexey S. Kabanov, Sergey A. Bodnev, Oleg V. Pyankov, Oksana P. Os'kina, Maria V. Sivay, Andrey V. Bespalov, Tatyana V. Tregubchak, Larisa N. Shishkina, Oleg S. Taranov, Vladimir V. Zolin, Artemiy A. Sergeev, Alexander P. Agafonov

“…The disease was confirmed by PCR followed by determination of the nucleotide sequence of viral DNA by sequencing. Isolation of the new MPXV strain from clinical samples was carried out in Vero E6 cells. …”
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Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis by Denisa Kavrikova, Petra Borilova Linhartova, Svetlana Lucanova, Hana Poskerova, Antonin Fassmann, Lydie Izakovicova Holla

“…A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580). …”
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Distribution and species composition of potato viruses in the Novosibirsk region by V. S. Maslennikova, M. B. Pykhtina, K. A. Tabanyukhov, E. V. Shelikhova, K. I. Mosalev, A. V. Katokhin, A. A. Bondar, A. B. Beklemishev, M. I. Voevoda

“…To develop methods for determining the strain affiliation of the studied samples, the nucleotide sequences of the capsid protein genes of 10 Y-virus isolates were sequenced. …”
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Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…The high-throughput sequencing project “1 000 Genomes” made it possible to catalog and utilize genetic loci and single nucleotide polymorphisms (SNPs) in medicine. Analysis of SNP markers (significantly frequent differences of individual genomes of patients from the reference human genome) allows physicians to optimize treatment. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…However, the bEV proteomes were more diverse in patients than in the controls and were enriched with proteins associated with the metabolism of amino acids and carbohydrates, nucleotide binding, and oxidoreductase activity. Metadata classification of samples was more accurate using fecal bEVs (100%) compared with fecal samples (93%). …”
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Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomize... by Feifei Xu, Tingting Liu, Huiqing Liu, Jiao Deng, Shan He, Zhihong Lu, Haopeng Zhang, Hailong Dong

“…Serum levels of myeloid differentiation factor 2 (MD2) and Cystatin C and PND-associated single nucleotide polymorphisms were analyzed by ELISA and whole genome sequencing, respectively. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Our prior research suggests that Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-related neuroinflammation, modulated by glial cells such as astrocytes, is likely to play a crucial role in the progression of anxiety and cognitive dysfunction. …”
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Prospective surveillance study to detect antimalarial drug resistance, gene deletions of diagnostic relevance and genetic diversity of Plasmodium falciparum in Mozambique: protocol by Alexandra Wharton-Smith, Caterina Guinovart, Pedro Aide, Francisco Saute, Alfredo Mayor, Bryan Greenhouse, Baltazar Candrinho, Joshua L Proctor, Arantxa Roca-Feltrer, Clemente da Silva, Eduard Rovira-Vallbona, Craig Bonnington, Caitlin Bever, Arlindo Chidimatembue, Maria Rodrigues, Neide Canana, Paulo Arnaldo, Simone Boene, Sonia Enosse

“…We will use a multiplex amplicon-based next-generation sequencing approach targeting informative single nucleotide polymorphisms, gene deletions and microhaplotypes. …”
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EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens by Mao Ye, Xiaohuan Chao, Chutian Ye, Lijin Guo, Zhexia Fan, Xuerong Ma, Aijun Liu, Weiming Liang, Shuya Chen, Cheng Fang, Xiquan Zhang, Qingbin Luo

“…In a population of Jiangfeng M3 lineage partridge chickens, we identified 4 EGR1 single-nucleotide polymorphisms, 2 of which were significantly associated with slaughter traits, including live weight, slaughter weight, semi-eviscerated weight, eviscerated weight, leg weight, wing weight, and breast muscle rate. …”
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Traces of Paleolithic expansion in the Nivkh gene pool based on data on autosomal SNP and Y chromosome polymorphism by V. N. Kharkov, N. A. Kolesnikov, L. V. Valikhova, A. A. Zarubin, A. L. Sukhomyasova, I. Yu. Khitrinskaya, V. A. Stepanov

“…The gene pool of the Nivkhs and other Far Eastern and Siberian populations was characterized using a genome-wide panel of autosomal single-nucleotide polymorphic markers and Y chromosome haplogroups. …”
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Transfer of Cytoplasmic Male Sterility to the Female Parents of Heat- and Drought-Resilient Maize (<i>Zea mays</i> L.) Hybrids by Ayyanagouda Patil, Kushal Gowda, Shivananda T. Lakshman, Prakash H. Kuchanur, Gajanan Saykhedkar, Sudha Krishnan Nair, Kisan B. Jadhav, Sharanabasappa Yeri, Gururaj Sunkad, Jayaprakash M. Nidagundi, Vinayan Madhumal Thayil, Pervez H. Zaidi

“…The present research used Diversity Array Technology (DArTag) and Kompetitive Allele Specific PCR (KASP)-based single-nucleotide polymorphic markers for background selection in backcross populations. …”
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Relationship between vaginal and gut microbiome and pregnancy outcomes in eastern Ethiopia: a protocol for a longitudinal maternal-infant cohort study (the EthiOMICS study) by Piet Cools, Alemseged Abdissa, Abera Kenay Tura, Nega Assefa, Merga Dheresa, Kedir Teji Roba, Tara Wilfong, Tesfaye Assebe Yadeta, Fitsum Weldegebreal, Desalegn Admassu Ayana, Akewok Sime Negesa, Yohannes Mulugeta Demmu, Tewodros Tesfa, Tegbaru Nibrat Alemu, Tadesse Gure Eticha, Abraham Geremew, Abel Abera Negash

“…Clinical study data will be submitted to Data Compass (https://datacompass.lshtm.ac.uk/), and molecular profiles of the microbiome and whole-genome sequences will be submitted to the European Nucleotide Archive (https://www. ebi.ac.uk/ena). Requests for data should be directed to daberaf@gmail.com. …”
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The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults by Hehua Zhang, Yong Feng, Honghao Yang, Yuqian Li, Zheng Ma, Liuxin Li, Liangkai Chen, Yuhong Zhao, Lishen Shan, Yang Xia

“…Polygenic score of GMA was calculated using 19 distinct single nucleotide polymorphisms. PM2.5 exposure was predicted using a validated Land Use Regression model. …”
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Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

“…<b>Methods:</b> This study systematically evaluated 151 single-nucleotide polymorphisms in <i>DENN</i> domain-containing genes in 458 patients with prostate cancer and BCR, followed by validation in an independent cohort of 185 patients. …”
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Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia by S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda

“…Previously, two single-nucleotide polymorphisms of innate-immunity genes – rs5743708 (Arg753Gln) of the TLR2 gene and rs8177374 (Ser180Leu) of the TIRAP gene – have been shown to be associated with both pneumonia and tuberculosis in humans, but the data are contradictory among different ethnic groups. …”
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Characterization of Myf6 and association with growth traits in swimming crab (Portunus trituberculatus) by Baohua Duan, Weibiao Liu, Chen Zhang, Tongxu Kang, Haifu Wan, Shumei Mu, Yueqiang Guan, Zejian Li, Yang Tian, Yuqin Ren, Xianjiang Kang

“…Expression pattern analysis of Myf6 in fast- and slow-growing groups revealed that the expression level of the latter was significantly higher than that of the former (P < 0.05). qPCR studies revealed that Myf6 was expressed in various tissues with the highest level in muscle. Nineteen single nucleotide polymorphisms (SNPs) of Myf6 were identified and five of them were significantly associated with growth-related traits of P. trituberculatus (P < 0.05), including full carapace width, carapace length, body height, and body weight. …”
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Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study by Ming-Jie Jia, Hua-Fang Yin, Ying-Chao Liang, Feng Jiang, Hui-Lin Li, Hui-Lin Li

“…However, whether there is a genetic causal effect between serum trace elements, nutrients, and autoimmune diseases remains unclear.ObjectiveThis study aims to investigate the causal effects of serum trace elements and nutrients on 21 autoimmune diseases using Mendelian randomization (MR).MethodsSingle nucleotide polymorphisms for the exposure factors (serum trace elements and vitamins) were obtained from the published UK Biobank database and genome-wide association study (GWAS) public databases. …”
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