Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy by Dong-Mei Zhu, Jing Xie, Chun-Yan Ye, Mei-Yun Qian, Yuan Xue

“…The incidence of HCC in patients receiving nucleoside analogues, nucleotide analogues, and combination therapy was 34.7%, 38.1%, and 33.3%, respectively, and the difference showed no significant differences (P = 0.95). …”
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The genomic pattern of insertion/deletion variations during rice improvement by Xia Zhou, Jilong Li, Lei Chen, Minjie Guo, Renmin Liang, Yinghua Pan

“…Although extensive research has utilized single nucleotide polymorphisms (SNPs) data to explore the genetic basis of important agronomic traits in rice improvement, reports on the role of other types of variations, such as insertions and deletions (INDELs), are still limited. …”
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Genome-wide association study for charcoal rot resistance in soybean harvested in Kazakhstan by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, A. Maulenbay, C. Fang, Y. Turuspekov

“…Genotypic data consisted of two sets: the results of genotyping using the Illumina iSelect 6K SNP (single-nucleotide polymorphism) array and the results of whole-genome resequencing. …”
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Genetic studies of normal tension glaucoma by D.Yu. Plotnikov, E.V. Valeeva

“…In addition, an association of single-nucleotide polymorphisms of the Toll-like receptor 4 gene with NTG was revealed. …”
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Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch. by Rui Cao, David P Schladt, Casey Dorr, Arthur J Matas, William S Oetting, Pamala A Jacobson, Ajay Israni, Jinbo Chen, Weihua Guan

“…An AR polygenic risk score (PRS) was constructed with the non-HLA single nucleotide polymorphisms (SNPs) filtered by independence (r2 < 0.2) and P-value (< 1×10-3) criteria. …”
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Association of LPCAT1-rs8352 genetic variant with susceptibility and severity of pediatric bronchial asthma: a case-control study by Khalid M. Mohany, Yasser Gamal, Yaser F. Abdel Raheem

“…Abstract Background This study aimed to investigate the possible association of LPCAT1-rs8352 genetic variant (single nucleotide change C to G) with the onset and severity of pediatric asthma. …”
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Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia by Wanyi Zhang, Rina Su, Hui Feng, Li Lin, Chen Wang, Huixia Yang

“…This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transgenerational offspring and discuss the effects of Rho guanine nucleotide exchange factor 11 (ARHGEF11) and the PI3K/AKT signaling pathway in offspring development. …”
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Glycemic Control in Type 2 Diabetes Mellitus Patients Could Affect NLRP3 Inflammasome Level by Refif Sabih Al-Shawk, Zainab Fadhel Ashoor, Wasan Abdul-elah Bakir, Intisar Manfi Ahmed

“…Background: Inflammasome complex such as nucleotide oligomerization domain-like receptor family protein 3 (NLRP3) acts as a trigger initiating inflammatory responses and could lead to endothelial dysfunction in diabetic patients and glycemic control could affect the mitochondrial stress through NLRP3 inflammasome level. …”
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CRISPR/Cas9, a universal tool for genomic engineering by A. V. Smirnov, A. M. Yunusova, V. A. Lukyanchikova, N. R. Battulin

“…The CRISPR/Cas9 system was initially described as an element of archeal and bacterial immunity, but gained much attention recently for its outstanding ability to be programmed to target any genomic loci through a short 20-nucleotide sgRNA region. Here we review some modern applications of the CRISPR/Cas9 system. …”
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Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis by QiXing Chen, Yang Yang, YiHang Pan, LiHua Shen, Yan Zhang, Fei Zheng, Qiang Shu, XiangMing Fang

“…Moreover, genetic deficiency of nucleotide-binding oligomerization domain-like receptor protein-3 or caspase-1 abrogated the high mortality and disrupted liver interendothelial junctions caused by high dose of HNP-1 during sepsis. …”
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IL-6 variant is associated with metastasis in breast cancer patients. by Chike O Abana, Brian S Bingham, Ju Hwan Cho, Amy J Graves, Tatsuki Koyama, Robert T Pilarski, A Bapsi Chakravarthy, Fen Xia

“…Interleukin 6 (IL-6) has emerged as an important factor in breast cancer progression with IL-6 single nucleotide polymorphism (SNP) variants shown to affect survival. …”
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Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study by Kaiwen Wang, Yu Lou, Shunjie Tian, Zhihui Tao, Zhihui Tao

“…ObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. …”
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Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population by Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova

“…The simplest type of such mutations is single nucleotide polymorphisms. Aims: The aim of the study is to study the relationship between gene polymorphisms of anti- and pro-inflammatory cytokines – interferon-gamma (T874A), interleukin (IL1B) (C3954T), IL6 (G572C) and IL10 (G1082A); placental function, apoptosis and angiogenesis – apolipoprotein C-III (APOC3) (G5163C), kinase insert domain receptor (A1719T, G1192A), P53 (Arg72Pro) and signal transducer and activator of transcription 3 (STAT3) (C1697G) with the development of idiopathic RM (iRM) in the Kazakh population. …”
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Priestia flexa as a Novel Urinary Tract Pathogen in Daloa, Côte d’Ivoire: Insights From Genomic Sequencing by Dého Aristide Gbégbé, Okran Beyosse Christophe Kacou, N’goran Parfait N’zi, Djédoux Maxime Angaman

“…Bacterial strains coded 21LM367, 21LM07, and 21LM1136 were isolated from the urine of patients with urinary tract infections (UTIs) at the Centre Hospitalier Régional de Daloa in Côte d’Ivoire. Based on average nucleotide identity (ANI) analysis, DNA-DNA digital hybridisation (dDDH), and other comparative genomic methods, strains 21LM07, 21LM367, and 21LM1136 were determined to be Priestia flexa. …”
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Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). …”
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Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability. by Pedro H N Aguiar, Carolina Furtado, Bruno M Repolês, Grazielle A Ribeiro, Isabela C Mendes, Eduardo F Peloso, Fernanda R Gadelha, Andrea M Macedo, Glória R Franco, Sérgio D J Pena, Santuza M R Teixeira, Leda Q Vieira, Alessandra A Guarneri, Luciana O Andrade, Carlos R Machado

“…We focused on the MutT enzyme, which is responsible for removing 8-oxoG from the nucleotide pool. To investigate the importance of 8-oxoG during parasite infection of mammalian cells, we characterized the MutT gene in T. cruzi (TcMTH) and generated T. cruzi parasites heterologously expressing Escherichia coli MutT or overexpressing the TcMTH enzyme. …”
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Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses by Irem Ozel, Ilgin Akkaya, Ece Oylumlu, Goksu Uzel, Ceren Ciraci

“…NLRP11 is a member of the PYD domain-containing, nucleotide-binding oligomerization-domain (NOD-) like receptor (NLR) family. …”
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Spread of TEM, VIM, SHV, and CTX-M β-Lactamases in Imipenem-Resistant Gram-Negative Bacilli Isolated from Egyptian Hospitals by El sayed Hamdy Mohammed, Ahmed Elsadek Fakhr, Hanan Mohammed El sayed, Said abd Elmohsen Al Johery, Wesam Abdel Ghani Hassanein

“…There is a high occurrence of β-lactamase genes in clinical isolates and sequence analysis of amplified genes showed differences between multiple SNPs (single nucleotide polymorphism) sites in the same gene among local isolates in relation to published sequences.…”
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Genetic aspects of lactase deficiency in indigenous populations of Siberia by B. A. Malyarchuk

“…In East Asian populations, including Siberian ethnic groups, a ~26.5 thousand nucleotide pairs long region of the MCM6 gene, including a combination of the rs4988285-A, rs2070069-G, rs3087353-T, and rs2070068-A alleles, was found. …”
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Effect of Combining Multiple CNV Defining Algorithms on the Reliability of CNV Calls from SNP Genotyping Data by Soon-Young Kim, Ji-Hong Kim, Yeun-Jun Chung

“…In addition to single-nucleotide polymorphisms (SNP), copy number variation (CNV) is a major component of human genetic diversity. …”
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