Gene Expression Analysis of Deduced Protein Sequence from the FLOWERING LOCUS C (FLC) Homolog during Vegetative and Reproductive Phases in Lepidium sativum L. by Parissa Jonoubi, Farkhondeh Rezanejad, Fatemeh Mahyapoor

“…Specific primers were designed for the RT-PCR assays, amplifying a 361-nucleotide fragment of the LsFLC gene, recorded in the NCBI database under the accession number GenBank: KT582105.1. …”
Get full text

Cloning and expression analysis of the glucocorticoid receptors and the effects of cortisol in sex differentiation in protogynous hermaphroditic swamp eel, Monopterus albus by Jialin Su, Lei Sun, Jiaqi Yang, Weizhi Yao, Hongyan Xu, Ke Feng

“…A novel alternative splicing variant (gr1b) was also discovered, which lacked a 27-bp nucleotide insertion in gr1, resulting in a nine-amino-acid deletion in GR1. …”
Get full text

Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster by Roberto Piergentili

“…Nonetheless, a more accurate analysis reveals that this chromosome can influence several complex phenotypes: (1) it has a role in the fertility of both sexes and viability of males when over-represented; (2) it can unbalance the intracellular nucleotide pool; (3) it can interfere with the gene expression either by recruiting proteins involved in chromatin remodeling (PEV) or, to a higher extent, by influencing the expression of up to 1,000 different genes, probably by changing the availability of transcription factors; (4) it plays a major role (up to 50%) in the resistance to heat-induced male sterility; (5) it affects the behavior; and (6) it plays a role in genetic imprinting. …”
Get full text

Genetic Population of Hypothenemus hampei Ferarri (Coleoptera: Scolytinae) from Coffee (Coffea spp.) in Sumatra, Indonesia Using The Cytochrome Oxidase Subunit I Gene by Aida Fitriani Sitompul, Dahelmi Dahelmi, Dewi Imelda Roesma

“…Haplotype analysis of the COI gene in H. hampei from Sumatra revealed 10 haplotypes, with a haplotype diversity (h) of 0.649 and nucleotide diversity (π) of 0.004. Genetic differentiation (Fst) of H. hampei is low among populations in Sumatra. …”
Get full text

The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis by Qiang Xiao, Susu Dong, Yafen Tan, Xuan Zhang, Lu Yao, Qiuping Li, Tianli Wang

“…The purpose of this study was to use Mendelian randomization (MR) analysis to investigate the causal relationship between smoking phenotypes and OA risk from a genetically informed standpoint.MethodsAs instrumental variables (IVs) based on single nucleotide polymorphisms (SNPs), this study used the summary-level data of corresponding genome-wide association study (GWAS) for five smoking phenotypes involving 1,694,781 samples. …”
Get full text

A Survey of SNP Data Analysis by Xiaojun Ding, Xuan Guo

“…As such, differences in human genomes are very worthy of study. Single-Nucleotide Polymorphisms (SNPs) are the simplest form and most common source of genetic polymorphism. …”
Get full text

The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank by Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim

“…Analysis of pleiotropic contributions of two sexually-dimorphic single-nucleotide polymorphisms related to thyroid disorders further validated a distinct genetic architecture across sexes that influences associations, confirmed through examination of corresponding gene expression profiles from the GTEx Portal. …”
Get full text

Genetic diversity and differentiation of cultured Nile tilapia populations from Ethiopia revealed by ddRAD-seq: implications for better hatchery management by Geletu Temesgen Tola, Tang Shoujie, Zhao Jinliang

“…Expected heterozyosity (He), observed heterozygosity (Ho) and nucleotide diversity (π) estimates indicated moderate within-population genetic diversity (mean: He = 0.24, Ho = 0.25, π = 0.25). …”
Get full text

低浓度三氯乙烯诱发L-02 肝细胞蛋白质组异常表达 by 黄海燕, 庄志雄, 刘建军, 李习艺, 卫秦芝, 杨晓华

“…低剂量三氯乙烯刺激后, 上调的蛋白有核糖体样蛋白( similar to ribosomal protein) 和SET protein, 下调的蛋白有异柠檬酸脱氢酶( isocitrate dehydrogenase, NADP) 和腺苷二磷酸- 核糖基 化因子鸟苷酸因子6 ( ADP-ribosylation factor guanine nucleotide factor 6) , 微管- 肌动蛋白交叉连接因子1 (microtubule-actin crosslinking factor 1) 特异表达, 肽基脯氨酰顺- 反异构酶PPI ( peptidyl prolyl cis/trans isomerase) 缺失。…”
Get full text

Associations between an gene polymorphism and ulcerative colitis by ARMS-PCR by Mahsa Sadat Hashemi Doulabi, Reza Goleyjani Moghaddam, Ali Salehzadeh

“…It was found that a single-nucleotide polymorphism at rs309 in the MDM2 gene was associated with ulcerative colitis. …”
Get full text

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene. by Min Zhang, Karim Mouzannar, Zhensheng Zhang, Yuji Teraoka, Jason Piotrowski, Yuji Ishida, Chise Tateno-Mukaidani, Takeshi Saito, Hiromi Abe-Chayama, Kazuaki Chayama, T Jake Liang

“…HBV genotype A has two major subtypes, A1 (commonly in Africa) and A2 (commonly in Europe) with only 4% nucleotide differences. Individuals infected with these two subtypes appear to have different clinical manifestations and virologic features. …”
Get full text

Molecular Detection and Determination of Phylogenetic Position of Watermelon Chlorotic Stunt Virus Khouzestan Isolate Based on Coat Protein Gene by Samira Pakbaz, Zahra Jelavi, Ehsan Hasanvand, Hossein Mirzaei Najafgholi

“…Also, results of two by two comparisons of nucleotide sequences of the AV1 genomic region using SDT v1.2 software showed the sequences of three Khouzestan isolates are highly similar (99.40%) and had the most identity (99.60%) with Noorabad Mamassani isolate from Fars province and the greatest genetic distance with Saudi Arabia isolates (95.80%) and Lebanon isolate (96.50%). …”
Get full text

High-throughput analysis of microbiomes in a meat processing facility: are food processing facilities an establishment niche for persisting bacterial communities? by Zhaohui S. Xu, Vi D. Pham, Xianqin Yang, Michael G. Gänzle

“…Isolates obtained at different sampling times or from different sampling sites that differed in fewer than 10 genome-wide single-nucleotide polymorphisms were considered the same (persistent) strains. …”
Get full text

Expanding the Diversity of <i>Actinobacterial Tectiviridae</i>: A Novel Genus from <i>Microbacterium</i> by Jacqueline M. Washington, Holly Basta, Angela Bryanne De Jesus, Madison G. Bendele, Steven G. Cresawn, Emily K. Ginser

“…Although the novel bacteriophages have 91.6 to 97.5% nucleotide sequence similarity to each other, they are at most 58% similar to previously characterized <i>Tectiviridae</i> genera. …”
Get full text

Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection. by Samuel Cordey, Tom J Petty, Manuel Schibler, Yannick Martinez, Daniel Gerlach, Sandra van Belle, Lara Turin, Evgeny Zdobnov, Laurent Kaiser, Caroline Tapparel

“…Comparison of five full-length genomes sequenced directly from respiratory, gastrointestinal, nervous system, and blood specimens revealed three nucleotide changes that occurred within a five-day period: a non-conservative amino acid change in VP1 located within the BC loop (L97R), a region considered as an immunogenic site and possibly important in poliovirus host adaptation; a conservative amino acid substitution in protein 2B (A38V); and a silent mutation in protein 3D (L175). …”
Get full text

Copper and iron as unique trace elements linked to fibromyalgia risk by Wenxing Zeng, Minhua Hu, Luyao Ma, Feng Huang, Ziwei Jiang

“…Genetic instrumental variables (single nucleotide polymorphisms, SNPs), related to these trace elements and FM were extracted from genome-wide association studies (GWAS). …”
Get full text

Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation. by Hu Zhang, Quanxin Long, Yuanjie Liu, Alexander L Marchetti, Cheng-Der Liu, Ning Sun, Haitao Guo

“…Hepatitis B virus (HBV) relaxed circular DNA (rcDNA) possesses an 8-9 nucleotide-long terminal redundancy (TR, or r) on the negative (-) strand DNA derived from the reverse transcription of viral pregenomic RNA (pgRNA). …”
Get full text

Revealing Genomic Profile That Underlies Tropism of Myeloma Cells Using Whole Exome Sequencing by Youngil Koh, Daeyoon Kim, Woo-June Jung, Kwang-Sung Ahn, Sung-Soo Yoon

“…We extracted DNA from SNU_MM1393_BM and SNU_MM1393_SC and performed WES. For single nucleotide variants (SNV) calling, we used Varscan2. …”
Get full text

Molecular Characterization of Legionellosis Drug Target Candidate Enzyme Phosphoglucosamine Mutase from (strain Paris): An Approach by Anayet Hasan, Habibul Hasan Mazumder, Arif Khan, Mohammad Uzzal Hossain, Homaun Kabir Chowdhury

“…Phosphoglucosamine mutase is involved in amino sugar and nucleotide sugar metabolism. The purpose of this study was to predict the potential target of that specific drug. …”
Get full text

Taenia asiatica: Mitochondrial signatures based analysis of an emerging public health threat in India by Aman D. Moudgil, Anil K. Nehra, Pallavi Moudgil

“…Overall, 2 and 6 haplotypes for the overall data set with low nucleotide (0.00399 ± 0.00237 and 0.00095 ± 0.00042) and low haplotype (0.400 ± 0.237 and 0.131 ± 0.054) diversities were recorded for the nad1 and cox1 genes, respectively. …”
Get full text