A study on the codon usage bias of arenavirus common genes by Pablo Daniel Thomas, María Florencia Ferrer, Mauricio J. Lozano, Ricardo Martín Gómez

“…Patterns of relative use of synonymous codons were maintained within genera, with individual genera differing in their preference for the third nucleotide position in synonymous codons. Of the three proteins examined, the ARN polymerase L protein exhibited a slightly stronger codon usage bias, but overall, the patterns were repeated between genera for the three proteins examined. …”
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Assessing the Impact of Aldose Reductase (ALR2) Regulatory Gene Polymorphism in Diabetic Retinopathy Patients by Hadiza Rabe Musa, Amina Rabe Musa, Yahuza Gimba Muhammed, Usman Salisu Batagarawa, Aminu Ibrahim

“…Molecular analysis unveiled single nucleotide polymorphisms (SNPs) at nucleotide position -106 within two samples (DR6 and D3). …”
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Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…The whole-genome sequencing revealed rare variants in three out of five analyzed patients: a heterozygous variant (rs760657350) located in a splicing acceptor site in the PLD1 gene (c.2430-1G>A), a previously undescribed single-nucleotide deletion in the SIDT1 gene [c.2426del (p.Leu809CysfsTer2)], new missense variant c.10313C>G (p.Pro3438Arg) in the LRP1B gene, and single-nucleotide deletion variant rs753876598 [c.165del (p.Ser56AlafsTer11)] in the CETP gene. …”
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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae by Qian Qin, Yanjing Dong, Jialong Chen, Bo Wang, Yuxin Peng, XinPeng Zhang, Xiaoyun Wang, Jinxiang Zeng, Guoyue Zhong, Shouwen Zhang, Xiaolang Du

“…Genetic characteristic analysis revealed a plentiful presence of SSR loci, with single-nucleotide repeats and dinucleotide (A/T) repeats being the most predominant. …”
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Binding of Dumbbell Oligonucleotides to MoMuLV Reverse Transcriptase: Inhibitory Properties of RNase H Activity by Ajay Kumar

“…Our value studies demonstrated that this particularly designed oligonucleotide displays an IC50 of 18 nM in its inhibition on the reverse transcriptase RNase H activity, a magnitude lower than that of first nucleotide reverse transcriptase of HIV-1, tenofovir, introduced by Gilead Science in the market.…”
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The Role of Mitochondria from Mature Oocyte to Viable Blastocyst by Scott Chappel

“…Mitochondria obtained from oocytes of women of advanced reproductive age harbor DNA deletions and nucleotide variations that impair function. The combination of lower number and increased frequency of mutations and deletions may result in inadequate mitochondrial activity necessary for continued embryo development and cause pregnancy failure. …”
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Assembly of the salt-secreting mangrove Avicennia rumphiana. by Jeremy R Shearman, Chaiwat Naktang, Chutima Sonthirod, Wasitthee Kongkachana, Sonicha U-Thoomporn, Nukoon Jomchai, Chatree Maknual, Suchart Yamprasai, Poonsri Wanthongchai, Wirulda Pootakham, Sithichoke Tangphatsornruang

“…Sequence comparison showed that 68.7% of the A. rumphiana genome aligned to A. marina sequence, covering 72% of the A. marina genome at an average nucleotide identity of 87.7%, showing that A. marina is closely related to A. rumphiana and, thus, suitable for reference based scaffolding of the A. rumphiana Supernova-scaffolds. …”
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Effect of Methylation on Storage Properties of Lacticaseibacillus paracasei as Analyzed by Untargeted Metabolomics by YOU Mingkun, ZHANG Wenyi

“…Using untargeted metabolomics, 269 differential metabolites were observed in the mutant compared with the wild type, which were mainly enriched in the nucleotide metabolism, purine metabolism, pyrimidine metabolism, citrate cycle, glyoxylate, and dicarboxylate metabolism pathways in the negative ion mode. …”
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Particulate Matter-Induced Acute Coronary Syndrome: MicroRNAs as Microregulators for Inflammatory Factors by Nur Izah Ab Razak, Nor Eliani Ezani, Norzian Ismail

“…Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. …”
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Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis by Rebecca Russ, Frank J. Slack

“…Cigarette smoke may lead to genetic or epigenetic damage to miRNAs, many of which map to fragile sites and some of which contain single nucleotide polymorphisms. Cigarette smoke may also cause dysregulation by affecting regulatory mechanisms controlling miRNA expression. …”
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A Review of Electroanalytical Techniques for Determination of Anti-HIV Drugs by Burçin Bozal, Bengi Uslu, Sibel A. Özkan

“…These compounds fall into six categories: nucleoside reverse transcriptase inhibitors (NRTIs: zidovudine, didanosine, zalcitabine, lamivudine, abacavir, stavudine, and emtricitabine), nucleotide reverse transcriptase inhibitors (NtRTIs: tenofovir), nonnucleoside reverse transcriptase inhibitors (NNRTIs: efavirenz, nevirapine, delavirdine, and etravirine), protease inhibitors (PIs: ritonavir, indinavir, saquinavir, nelfinavir, amprenavir, lopinavir, fosamprenavir, atazanavir, tipranavir and darunavir), fusion inhibitors (FIs: enfuvirtide), coreceptor inhibitors (CRIs: maraviroc), and integrase inhibitors (INIs: raltegravir). …”
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How data science and AI-based technologies impact genomics by Jing Lin, Kee Yuan Ngiam

“…In this review, we focus on the application of data science and AI technology in three areas, including risk prediction and identification of causal single-nucleotide polymorphisms, EHR-based phenotyping and CRISPR guide RNA design. …”
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Genome Architecture and Its Roles in Human Copy Number Variation by Lu Chen, Weichen Zhou, Ling Zhang, Feng Zhang

“…Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. …”
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HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions by Sungkyoung Choi, Sungyoung Lee, Taesung Park

“…The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. …”
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The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review by Arezina Kasti, Konstantinos Katsas, Maroulla D. Nikolaki, Konstantinos Triantafyllou

“…NLRP3 inflammasome is part of the nucleotide-binding oligomerization domain-like receptor (NLR) family, a crucial component of the innate immune system. …”
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IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes by Amandine Martin, Solène Caron, Mélissa Marcotte, Pauline Bronnec, Etienne Garneret, Nora Martel, Georgina Maalouf, Pascal Sève, David Saadoun, Yvan Jamilloux, Thomas Henry

“…Summary: Alpha-kinase 1 (ALPK1) is an immune receptor sensing the bacterial nucleotide sugar ADP-heptose. ALPK1 phosphorylates TIFA leading to its oligomerization and downstream NF-κB activation. …”
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Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae by Moray Smith, John T Jones, Ingo Hein

“…Nucleotide-binding domain leucine-rich repeat (NLR) proteins are a key component of the plant innate immune system. …”
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Reduced Representation Libraries from DNA Pools Analysed with Next Generation Semiconductor Based-Sequencing to Identify SNPs in Extreme and Divergent Pigs for Back Fat Thickness by Samuele Bovo, Francesca Bertolini, Giuseppina Schiavo, Gianluca Mazzoni, Stefania Dall’Olio, Luca Fontanesi

“…The aim of this study was to identify single nucleotide polymorphisms (SNPs) that could be associated with back fat thickness (BFT) in pigs. …”
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SURFACE PLASMON RESONANCE STUDY OF THE INTERACTION BETWEEN THE HUMAN TATA-BOX BINDING PROTEIN AND THE TATA ELEMENT OF THE NOS2A GENE PROMOTER by I. A. Drachkova, S. V. Shekhovtsov, S. E. Peltek, P. M. Ponomarenko, T. V. Arshinova, M. P. Ponomarenko, T. I. Merkulova, L. K. Savinkova, N. A. Kolchanov

“…It is known that some single nucleotide polymorphisms (SNPs) in the human TATA box and its flanks are associated with elevated risk ofvarious disorders (Savinkova etal., 2009). …”
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New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy by Mengran Li, Mengran Li, Hu Tian, Yanshuang Zhuang, Zili Zhang, Zili Zhang

“…N6-methylation is a modification in which a methyl group is added to the adenine base of a nucleotide. This modification is crucial for controlling important functions that are vital for gene expression, including mRNA splicing, stability, and translation. …”
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