Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution by Senouwa Segla Koffi Dossou, Qianchun Deng, Feng Li, Lei Wang, Nanjun Jiang, Habtamu Kefale, Rong Zhou, Donghua Li, Meilian Tan, Linhai Wang

“…Amino acids and derivatives (15.50%), flavonoids (14.77%), phenolic acids (12.19%), lipids (9.60%), carbohydrates and derivatives (8.47%), organic acids and derivatives (7.99%), nucleotides and derivatives (7.99%), and terpenoids (5.25%) were the major classes of metabolites in perilla leaves. …”
Get full text

Black carp RNF115 restricts IRF3/7-mediated antiviral signaling in innate immunity by Yixuan He, Qun Wang, Lili Xiao, Hui Wu, Jun Xiao, Jun Zou, Hao Feng

“…The open reading frame of black carp RNF115 contains 933 nucleotides and encodes 310 amino acids. The C-terminal RING domain of RNF115 is highly conserved among various homologous species. …”
Get full text

Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…Results A total of 172 stable and reliable quantitative trait nucleotides (QTNs) were identified, of which 77 are associated with GY, AD, SD, ASI, PH, EH, EPO and EPP under drought and 95 are linked to GY, AD, SD, ASI, PH, EH, EPO and EPP under optimal conditions. …”
Get full text

A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…Results We combined circRNA-seq and Ribo-seq data to screen a total of 18 circRNA candidates with coding potential, and circANKRD17 was found to be significantly elevated in the longissimus dorsi muscle of Lantang piglets, with a length of 1,844 nucleotides. Using single-cell sequencing, we identified 477 differentially expressed genes in IMF cells between Lantang and Landrace piglets, with enrichment in the PPAR signaling pathway. …”
Get full text

Functional hydrogel empowering 3D printing titanium alloys by Weimin Zhang, Jiaxin Zhang, He Liu, Yang Liu, Xiao Sheng, Sixing Zhou, Tiansen Pei, Chen Li, Jincheng Wang

“…Hydrogels composed of three-dimensional networks of hydrophilic polymers can effectively simulate the extracellular matrix of natural bone and are capable of loading bioactive molecules such as proteins, peptides, growths factors, polysaccharides, or nucleotides for localized release within the human body, by directly participating in biological processes. …”
Get full text

Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…The uptake of Al, metabolism of nucleotides (ATP, ADP, and AMP) and nucleoside (adenosine), and the gene expression and protein density of purinoceptors were investigated. …”
Get full text

L-glutaminase synthesis by Klebsiella pneumoniae (AS KP 23) isolated from clinical strain, and its efficacy against human hepatocellular and breast cancer cell lines by Lina J. Abdel-Hafez, Eman Y. T. Elariny, Asmaa E. Ibrahim, Mahmoud E. F. Abdel-Haliem

“…Glutamine serves as a carbon source for the synthesis of metabolites and lipids via the TCA cycle, as well as a source of nitrogen for the synthesis of amino acids and nucleotides. Recently, the role of glutamine metabolism in cancer has been explored in many studies. …”
Get full text

Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Predictive analysis highlighted 15 common proteins, up- or downregulated in PBMCs from patients with T1DM and MS patients vs. healthy controls, involved in the immune system activity (BTF3, TTR, CD59, CSTB), diseases of the neuronal system (TTR), signal transduction (STMN1, LAMTOR5), metabolism of nucleotides (RPS21), proteins (TTR, ENAM, CD59, RPS21, SRP9) and RNA (SRSF10, RPS21). …”
Get full text

DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model by Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu

“…More importantly, DeepAptamer effectively identified key nucleotides for target binding. DeepAptamer can efficiently identify high-affinity aptamers against various targets, enhancing its potential to discover promising sequences in initial screening stages and obviating the 20–30 iterative selection rounds required for full enrichment of selection pools. …”
Get full text

Populations of the Invasive Mussel <i>Mytella strigata</i> in China Showed Lower Genetic Diversity in Autumn than in Spring by Peizhen Ma, Chenxia Zuo, Shaojing Yan, Xiangyu Wu, Xiaojie Ma, Yi Zhu, Zhen Zhang

“…The Zhanjiang population had the highest genetic diversity in spring with 22 haplotypes, 37 polymorphic sites, and haplotype diversity, nucleotide diversity, and the average number of nucleotide differences being 0.911, 0.00623, and 4.341, respectively. …”
Get full text

The First Report of Tomato Yellow Leaf Curl Virus (TYLCV) Occurrence in Tomato Greenhouses of Lorestan Province by Farzaneh Rostami, Samira Pakbaz, Mostafa Darvishnia

“…The determined nucleotide sequences showed 94.79-97.63% and 90.5-95.69% nucleotide and amino acid identities with other available sequences of TYLCV in NCBI, respectively. …”
Get full text

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex by Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye

“…In this state, BODIPY-GDP/GTP based nucleotide exchange assays further indicated the α-helical domain of the Gα is partially open, allowing it to grasp a nucleotide at a non-canonical binding site, distinct from the canonical nucleotide-binding site. …”
Get full text

Analysis of whole genome sequence of strain "0" of avian infectious laryngotracheitis virus by A. A. Kozlov, N. G. Zinyakov, S. N. Kolosov, N. S. Mudrak, I. A. Chvala

“…Data on identification and analysis of whole genome nucleotide sequence of strain «O» of avian infectious laryngotracheitis virus are demonstrated. …”
Get full text

Molecular Characterization of Chicken Anemia Virus Circulating in Chicken Flocks in Egypt by Mohammed AboElkhair, Alaa G. Abd El-Razak, Abd Elnaby Y. Metwally

“…In the present study, four nucleotide sequences of detected CAV were genetically characterized. …”
Get full text

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques by Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir

“…Four sub‐datasets derived from the primary dataset Di‐nucleotide (DNC), Tri‐nucleotide (TNC), Tetra‐nucleotide (Tetra‐NC), and Penta‐nucleotide (Penta‐NC) were used to train the model. …”
Get full text

Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells by Fariborz Bahrami, Filip Kukulski, Joanna Lecka, Alain Tremblay, Julie Pelletier, Liliana Rockenbach, Jean Sévigny

“…We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors. Here we investigated whether IL-8 release by intestinal epithelial HT-29 cells, a cancer cell line, is modulated by extracellular nucleotide metabolism. …”
Get full text

Some limitations in the use of the mitochondrial DNA cytb gene as a molecular marker for phylogenetic and population genetic studies by the example of the Apodemus genus by A. G. Lapinski, M. V. Pavlenko, L. L. Solovenchuk, V. V. Gorbachev

“…The effects of hypervariability in cytb nucleotide sequences of some samplings resulting in entropy growth imitating gene conversion when compared to other species of the genus were analyzed. …”
Get full text

A database on genes increasing resistance of wheat and relative species against pathogenic fungi by O. G. Smirnova, A. V. Kochetov

“…The database (Pathogenesis-Related Genes, PRG) contains information on gene chromosomal localizations and functional activities, nucleotide sequences and single nucleotide polymorphisms associated with their effects. …”
Get full text

The context signals of mitochondrial miRNAs (mitomiRs) of mammals by O. V. Vishnevsky, P. S. Vorozheykin, I. I. Titov

“…The identification of nucleotide signals, which are unique to mitomiRs, may help to determine this role. …”
Get full text

Genome-Wide Association Study of Hepatitis in Korean Populations by Youngbok Hong, Sejong Oh

“…About 300,000 single-nucleotide polymorphisms and 20 epidemiological variables were analyzed. …”
Get full text