AcfA Regulates the Virulence and Cell Envelope Stress Response of <i>Vibrio parahaemolyticus</i> by Huan Liu, Huayu Lei, Juanjuan Cao, Zhaobang Xie, Yile Shi, Yanni Zhao

“…In this work, Δ<i>acfA</i>, an in-frame deletion mutant strain lacking the 4th to the 645th nucleotides of the open reading frame (ORF) of the <i>acfA</i> gene, and the complementary strain <i>acfA</i>⁺ were constructed to decipher the function of AcfA in <i>V. parahaemolyticus</i>. …”
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The first two mitochondrial genomes from Apiotrichum reveal mitochondrial evolution and different taxonomic assignment of Trichosporonales by Qiang Li, Wenqi Xiao, Peng Wu, Ting Zhang, Peng Xiang, Qian Wu, Liang Zou, Mingying Gui

“…Comparative mitogenomic analysis revealed that 6.85–38.89% of nucleotides varied between tRNAs shared by the two Apiotrichum mitogenomes. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…While in mammals active demethylation is based on targeted regulated damage to mC in DNA followed by the action of repair enzymes, demethylation in plants is performed by specialized DNA glycosylases that hydrolyze the N-glycosidic bond of mC nucleotides. The genome of the model plant Arabidopsis thaliana encodes four paralogous proteins, two of which, DEMETER (DME) and REPRESSOR OF SILENCING 1 (ROS1), possess 5-methylcytosine-DNA glycosylase activity and are necessary for the regulation of development, response to infections and abiotic stress and silencing of transgenes and mobile elements. …”
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Complex bacterial diversity of Guaymas Basin hydrothermal sediments revealed by synthetic long-read sequencing (LoopSeq) by John E. Hinkle, John E. Hinkle, Jeffrey P. Chanton, Molly A. Moynihan, Molly A. Moynihan, S. Emil Ruff, S. Emil Ruff, Andreas Teske

“…In this study, LoopSeq is used to obtain near-full length (approximately 1,400–1,500 nucleotides) bacterial 16S rRNA gene sequences from hydrothermal sediments in Guaymas Basin. …”
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Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine by Masaki Hori, Shin-Ichiro Yonekura, Takehiko Nohmi, Petr Gruz, Hiroshi Sugiyama, Shuji Yonei, Qiu-Mei Zhang-Akiyama

“…Primer extension assays revealed that Pol IV preferred to insert dATP opposite 5-fodU and 5-hmdU, while it inefficiently inserted nucleotides opposite dTg. Pol IV inserted dCTP and dATP opposite 8-oxodG, while the ability was low. …”
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Screening and Characterization of High Protein Yeast with Excellent Stress Tolerance by DENG Juan-li, SUN Chang-po, ZHAO Yi-fan, LI Tian-tian, YIN Peng

“…Flavor analysis revealed that strain B-1 had a higher content of flavor nucleotides and glutamic acid than strain D-1, along with a greater concentration of ester compounds. …”
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History and prospects of flax genetic markers by Daiana A. Zhernova, Elena N. Pushkova, Tatiana A. Rozhmina, Elena V. Borkhert, Alexander A. Arkhipov, Alexander A. Arkhipov, Elizaveta A. Sigova, Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Ekaterina M. Dvorianinova, Alexey A. Dmitriev, Alexey A. Dmitriev, Nataliya V. Melnikova

“…QTLs and quantitative trait nucleotides (QTNs) were identified for valuable seed- and fiber-related features and for resistance to biotic and abiotic stressors. …”
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Unveiling the role of lncRNA ERDR1 in immune cell regulation by Aihua Shu, Xu Tian, Jie Yue, Yuxia Jiang, Yifei Liu

“…Long non-coding RNAs (lncRNAs) are a class of RNA molecules that exceed 200 nucleotides in length and lack the capacity to encode proteins. …”
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Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…Under both sensitized and catalyzed conditions, the nucleotides <mml:math alttext="G$^{13}$"> <mml:msup> <mml:mtext>G</mml:mtext> <mml:mrow> <mml:mn>13</mml:mn> </mml:mrow> </mml:msup> </mml:math>&#8211;<mml:math alttext="G$^{15}$"> <mml:msup> <mml:mtext>G</mml:mtext> <mml:mrow> <mml:mn>15</mml:mn> </mml:mrow> </mml:msup> </mml:math> were mainly modified, providing evidence that the reaction proceeded in the double-stranded oligonucleotide. …”
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Effects and function of citric acid on fermentation quality and microbial community in sugarcane tops silage with high and low water-soluble carbohydrate content by Qichao Gu, Jie Zhang, Bo Lin, Hao Ding, Qi Yan, Caixiang Wei, Yipei Yao, Ruizhanghui Wang, Caixia Zou

“…Moreover, the metabolism of energy and nucleotides was lower in high-WSC STS treated with CA, and the animal pathogens was lower in low-WSC STS treated with CA. …”
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Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response by Ceren Yalaz, Esther Bridges, Nasullah K. Alham, Christos E. Zois, Jianzhou Chen, Karim Bensaad, Ana Miar, Elisabete Pires, Ruth J. Muschel, James S. O. McCullagh, Adrian L. Harris

“…Results PDE6H knockout resulted in an increase of intracellular cGMP levels, as well as changes to the levels of nucleotides and key energy metabolism intermediates. …”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…The enzyme CD73, a cell surface 5′-nucleotidase, regulates the balance between pro-inflammatory nucleotides and anti-inflammatory adenosine. Diminished CD73-adenosine signaling contributes to severe infections.Methods: In this prospective cohort study, 393 patients who underwent HD for over six months were evaluated for CD73+Tcell ratios and were followed up for three years to track infection events. …”
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Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment by Giulia Gerini, Alice Traversa, Fabrizio Cece, Matteo Cassandri, Paola Pontecorvi, Simona Camero, Giulia Nannini, Enrico Romano, Francesco Marampon, Mary Anna Venneri, Simona Ceccarelli, Antonio Angeloni, Amedeo Amedei, Cinzia Marchese, Francesca Megiorni

“…<i>In silico</i> annotation and gene ontology analysis highlighted the activation of ethanol oxidation, ROS regulation, retinoic acid metabolism, and steroid hormone metabolism, as well as in the metabolism of lipids, amino acids, and nucleotides, and pinpointed potential new osteogenic drivers like AOX1 and ADH1A. …”
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Effect of Geographic Regions on the Flavor Quality and Non-Volatile Compounds of Chinese Matcha by Hongchun Cui, Yun Zhao, Hongli Li, Min Ye, Jizhong Yu, Jianyong Zhang

“…A total of 1131 differential metabolites were identified in the matcha samples, comprising 118 flavonoids, 14 tannins, 365 organic acids, 42 phenolic acids, 22 alkaloids, 39 saccharides, 208 amino acids and derivatives, 17 lignans and coumarins, seven quinones, 44 nucleotides and derivatives, 14 glycerophospholipids, two glycolipids, 15 alcohols and amines, 140 benzenes and substituted derivatives, 38 terpenoids, 30 heterocyclic compounds, and 15 lipids. …”
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Increased NTPDase Activity in Lymphocytes during Experimental Sepsis by Claudia de Mello Bertoncheli, Carine Eloise Prestes Zimmermann, Jeandre Augusto dos Santos Jaques, Cláudio Alberto Martins Leal, Jader Betsch Ruchel, Bruna Cipolatto Rocha, Kelly de Vargas Pinheiro, Viviane do Carmo Gonçalves Souza, Daniel Roulim Stainki, Sônia Cristina Almeida Luz, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal

“…It is known that the intracellular milieu contains much more ATP nucleotides than the extracellular. In this context, the increased ATPasic activity was probably induced as a dynamic response to clean up the elevated ATP levels resulting from cellular death.…”
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Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity by Zhang Q, Liang D, Zhang C, Ye L, Sun P, Zhu H, Zhao Y, Li Y, Guan Y, Zhang H

“…MTX primarily affected the processes of protein digestion and absorption, mineral absorption, membrane transport, production of aminoacyl-transfer RNA (tRNA), metabolism of nucleotides, lipids, and amino acids, as well as autophagy. …”
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THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS by A. М. Kondybayeva, A. N. Akimniyazova, S. U. Kamenova, A. Т. Ivashchenko

“…The binding sites of miR-2-6184-3p, miR-5-14114-5p and miR-19-43437-5p were located with overlapping nucleotides sequences, and encode polyPro. In ZFHX3 human polyPro consisted of 12 Pro. …”
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Serological, phenotypic and molecular characterization of brucellosis in small ruminants in northern Algeria by Ibrahim Nabi, Rachid Achek, Rachid Achek, Abdelkadir Karim, Falk Melzer, Hanka Brangsch, Mandy C. Elschner, Heinrich Neubauer, Hosny El-Adawy, Hosny El-Adawy

“…The highest base difference (449–462 nucleotides) was observed for an ovine isolate originating from Sidi Bel-Abbès. …”
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Metabolomics mechanism of traditional soy sauce associated with fermentation time by Li Zhu, Siyu He, Ying Lu, Jianhong Gan, Ningping Tao, Xichang Wang, Zaoli Jiang, Yuanxiang Hong, Changhua Xu

“…Results showed that formaldehyde nitrogen, total soluble nitrogen (TSN), non-salt soluble solids, amino acids, free 5’-nucleotides and volatile compounds in CTFSS changed obviously during fermentation. …”
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Comparison of different drying processes of Morchella sextelata: Changes in volatile and non-volatile components, color and texture by Yaxuan Liao, Mengdi Xin, Hao Dong, Yuxing Liu, Lingling Li, Xinyong Guo, Shaobo Cheng, Guogang Chen

“…In addition, the equivalent umami concentration (1293.20 g MSG/100 g) and total aroma compound content (2,533,403 μg/kg) for HAD-MVD were significantly higher than that for VFD, and the content of non-volatile substances such as soluble sugars, 5′-nucleotides, and total free amino acids were also high. …”
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