-
281
Molecular detection and genomic characterization of Samak Micromys paramyxovirus-1 and -2 in Micromys minutus, Republic of Korea
Published 2024-10-01“…One sequence was determined as Samak Micromys paramyxovirus 1 (SMPV-1; 19,911 nucleotides long) and three sequences as Samak Micromys paramyxovirus 2 (SMPV-2; 18,199 nucleotides long). …”
Get full text
Article -
282
MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE
Published 2024-12-01“…MicroRNAs (miRNAs), small non-coding RNA molecules consisting of approximately 22 nucleotides, play a critical role in modulating intracellular protein expression at the post-translational level through translational degradation. …”
Get full text
Article -
283
Case report: Deciphering the clinical significance of a novel partial BRCA1 exon 10 duplication in a patient with triple-negative breast cancer
Published 2025-02-01“…The identified duplication comprises 395 nucleotides from the final portion of intron 9 and 1617 nucleotides from the beginning of exon 10. …”
Get full text
Article -
284
Roles of Oncogenic Long Non-coding RNAs in Cancer Development
Published 2018-12-01“…Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly involved in a variety of biological processes and in the regulation of gene expression. …”
Get full text
Article -
285
Numerical Characterization of DNA Sequence Based on Dinucleotides
Published 2012-01-01“…The most important feature of this method is that it not only identifies adjacent XY pairs but also nonadjacent XY ones where X and Y are separated by some number of nucleotides. This methodology preserves information in DNA sequence that is ignored by other methods. …”
Get full text
Article -
286
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
Published 2025-01-01“…Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metabolisms remain incompletely understood. …”
Get full text
Article -
287
The therapeutic agents that target ATP-sensitive potassium channels
Published 2016-03-01“…Functional KATP channels are hetero-octamers composed of two subunits, a pore forming Kir6, which is a member of the inwardly rectifying potassium channels family, and a regulatory sulphonylurea receptor (SUR). In response to nucleotides and pharmaceutical agonists and antagonists, SUR allosterically regulates channel gating. …”
Get full text
Article -
288
Cassava–soybean intercropping alleviates continuous cassava cropping obstacles by improving its rhizosphere microecology
Published 2025-02-01“…The contents of phenol glucuronide, 2,3-butanediol, L-phenylalanine, deoxyguanosine, other carbohydrates, alcohols, purine nucleotides, and amino acids in the soil of the MD group were significantly upregulated. …”
Get full text
Article -
289
Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension
Published 2018-01-01“…The human genome is a very long DNA sequence which consists of billions of nucleotides arranged in a unique way. A single base-pair change in the DNA sequence is known as a single nucleotide polymorphism (SNP). …”
Get full text
Article -
290
Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
Published 2025-01-01“…Twenty-two of the 240 assayed MAX point mutations enhance selectivity, yet none of these mutations occur at residues that contact nucleotides in published structures. By applying thermodynamic and kinetic models to these results and previous observations for the highly similar yet far more selective TF Pho4 (S. cerevisiae), we find that these mutations enhance selectivity by altering partitioning between or affinity within conformations with different intrinsic selectivity, providing a mechanistic basis for allosteric modulation of ligand selectivity. …”
Get full text
Article -
291
Expression of a splice variant of the platelet-activating factor receptor transcript 2 in various human cancer cell lines
Published 2002-01-01“…It consisted of the PAF-R transcript 2 lengthening with 82 nucleotides from the 3' end of exon 1 of the PAF-R gene. …”
Get full text
Article -
292
Evaluation of the genome in bird breeding
Published 2017-12-01“…New technologies determining the DNA sequence of nucleotides have led to the discovery of hundreds of thousands of mononucleotide polymorphic markers, some of which are associated with breeding quality of animals. …”
Get full text
Article -
293
COVID-19 Whole-Genome Resequencing with Redundant Tiling PCR and Subtract-Based Amplicon Normalization Successfully Characterized SARS-CoV-2 Variants in Clinical Specimens
Published 2022-01-01“…Less than 5% were ambiguous nucleotides, and several known variants were detected. …”
Get full text
Article -
294
Imaging Gene Expression in Regional Brain Ischemia in Vivo with a Targeted [In]-Antisense Radiopharmaceutical
Published 2004-10-01“…The in vivo imaging of decreased GFAP gene expression in cerebral ischemia was examined in the present studies using a targeted peptide nucleic acid (PNA), which was labeled with 111 In, and which hybridized to nucleotides 20–37 of the rat GFAP mRNA. The PNA was monobiotinylated, and was attached to a monoclonal antibody (MAb) to the transferrin receptor (TfR) via a biotin–streptavidin linkage. …”
Get full text
Article -
295
Novel insights into the quality changes and metabolite transfer rules of pickles during fermentation: Pickle versus pickle solution
Published 2025-01-01“…After fermentation of the pickle solution, metabolites such as D-tartaric acid and mannitol were significantly up-regulated, and the metabolism of nucleotides, histidine and riboflavin was active. Additionally, metabolites in pickle such as ginnalin B and Gly-Asn-Phe were notably up-regulated, and nucleotide metabolism and phenylalanine metabolism were active. 32 metabolites from the pickle were found to dissolve into the pickle solution, and 18 metabolites in the pickle solution penetrated into the pickle, in order to provide the theoretical basis for the quality control and industrial development of low-salt pickle.…”
Get full text
Article -
296
LOX-1, OxLDL, and Atherosclerosis
Published 2013-01-01“…Inhibition of the LOX-1 receptor with chemicals or antisense nucleotides is currently being investigated and represents an emerging approach for controlling OxLDL-LOX-1 mediated proatherogenic effects.…”
Get full text
Article -
297
Deciphering metabolic differentiation during Bacillus subtilis sporulation
Published 2025-01-01“…Our results indicate that nucleotides are synthesized in the mother cell and transported in the form of nucleoside di- or tri-phosphates to the forespore via the Q-A channel. …”
Get full text
Article -
298
Early changes in microRNA expression in Arabidopsis plants infected with the fungal pathogen Fusarium graminearum.
Published 2025-01-01“…These short RNA molecules (20-22 nucleotides) have been shown to be important players in the early responses of plants to stresses because they can rapidly regulate the expression levels of a network of downstream genes. …”
Get full text
Article -
299
The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases
Published 2015-01-01“…The long noncoding RNAs (lncRNAs) are RNA transcripts more than 200 nucleotides in length, which do not encode proteins. …”
Get full text
Article -
300
Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy
Published 2024-12-01“…One of the possibilities is allosteric regulation by its natural allosteric modulators—nucleotides, co-chaperones and client proteins—and synthetic small-molecule allosteric modulators, such as those targeting the middle domain or the C-terminal domain (CTD) of Hsp90. …”
Get full text
Article