Self-replicating recombinant virus-like particles of lentivirus proliferating in glioblastoma cells and normal human macrophages by Herman D. Moshkoff, Andrey E. Moshkoff, Dmitry A. Moshkoff

“…Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. Immunity induced by inactivated vaccines is not believed to be long-lasting. …”
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Circulating miRNAs as Biomarkers for Prostate Cancer Diagnosis in Subjects with Benign Prostatic Hyperplasia by Wei Jin, Xiang Fei, Xia Wang, Fangjie Chen, Yan Song

“…Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. …”
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Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring by Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini

“…Cell membranes, proteins, and nucleic acids become the target of ROS and progressively lose their structure and functions. …”
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Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Functional annotation and pathway enrichment analyses highlighted significant involvement of DEmiRs and their target genes in cell cycle-related processes, including enrichment in the nucleus, transcription factor activity, regulation of nucleosides, nucleotide and nucleic acids, cell growth and/or maintenance, mitotic cell cycle, mitotic M-M/G1 phases an DNA replication. …”
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A Calorimetric Characterization of Cr(VI)-Reducing Arthrobacter oxydans at Different Phases of the Cell Growth Cycle by Nugzar G. Bakradze, Marina K. Abuladze, Victor M. Sokhadze, Nina V. Asatiani, Nelly A. Sapojnikova, Tamara M. Kartvelishvili, Emma N. Namchevadze, Nelly Y. Tsibakhashvili, Leila V. Tabatadze, Lia V. Lejava, Hoi-Ying Holman

“…In this paper we introduce a new concept of thermal spectrum of the endothermic melting of complex biological systems (e.g., proteins, nucleic acids, ribosomes, membrane structures) in intact cells. …”
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Inactivation of the TIM complex components leads to a decrease in the level of DNA import into Arabidopsis mitochondria by T. A. Tarasenko, K. D. Elizova, V. I. Tarasenko, M. V. Koulintchenko, Yu. M. Konstantinov

“…It has been known that nucleic acids enter plant organelles through alternative channels, depending on the size of the imported molecules. …”
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Morphogenetic peculiarities of reproductive biology in sugar beet (Beta vulgaris L.) breeding by T. P. Zhuzhzhalova, A. A. Nalbandyan, E. N. Vasilchenko, N. N. Cherkasova

“…It presents the results of using fluorescent microscopy, cytophotometry, biochemical analysis and determining the level of phytohormones and content of nucleic acids in nuclei for forecasting the seed setting ability. …”
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Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity by Shridhar Sanghvi, Divya Sridharan, Parker Evans, Julie Dougherty, Kalina Szteyn, Denis Gabrilovich, Mayukha Dyta, Jessica Weist, Sandrine V. Pierre, Shubha Gururaja Rao, Dan R. Halm, Tingting Chen, Panagiotis S. Athanasopoulos, Amalia M. Dolga, Lianbo Yu, Mahmood Khan, Harpreet Singh

“…EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. …”
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CRISPR/Cas13a combined with reverse transcription and RPA for NoV GII.4 monitoring in water environments by Yiqiang Sun, Weiwei Zhang, Houyun Zhang, Feng Zhao, Laijin Su

“…The use of glycerol as a phase separator and the direct release of nucleic acids from the virus by NaOH significantly enhanced the stability of the assay and reduced its economic cost. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Abstract Ribozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. …”
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Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis by Xuan Lin, Arya Vasanth, Aditya Ashok, Hoang-Phuong Phan, Kevin M. Koo, Mohammed A. Amin, Yusuf Valentino Kaneti, Carlos Salomon, Md Shahriar A. Hossain, Yusuke Yamauchi, Mostafa Kamal Masud

“…Sweat contains numerous vital biomarkers such as metabolites, electrolytes, proteins, nucleic acids and antigens that reflect hydration status, exhaustion, nutrition, and physiological changes. …”
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Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

“…Background: Liquid biopsy (LB) is a laboratory test performed on a fluid sample aiming at analyzing molecular data derived from circulating cells and related entities, or from nucleic acids. This umbrella review aims to map and evaluate the evidence supporting the use of LB in medicine across different medical specialities and conditions. …”
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Molecular Characterization and Evolution Analysis of Two Forms of TLR5 and TLR13 Genes Base on Larimichthys crocea Genome Data by Lihua Jiang, Liyi Pei, Ping Wang, Liqin Liu, Gong Li, Binjian Liu, Zhenming Lǚ, Tabata Hiromasa, Hao Pan, Atsushi Ogura

“…TLR13 is a TLR that localizes to endosomes and recognizes nucleic acids released by internal microorganisms, including viruses, bacteria, and fungi. …”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

“…With the rapid diversification and complexification of biologics, which today include modalities such as multi-domain antibodies, cell-based products, AAV delivery vectors, and nucleic acids, developers are faced with the challenge of establishing a risk assessment strategy sometimes in the absence of specific regulatory guidelines. …”
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RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 by Duanfeng Jiang, Xin Wu, Xiaoying Sun, Wei Tan, Xin Dai, Youbang Xie, Ashuai Du, Qiangqiang Zhao

“…Exosomes containing proteins or nucleic acids are secreted by cells; they participate in intercellular communication and serve as key modulators of hematopoiesis. …”
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Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes by Jersey Heitor da S. Maués, Helem Ferreira Ribeiro, Giovanny R. Pinto, Luana de Oliveira Lopes, Letícia M. Lamarão, Carla Mariana F. Pessoa, Caroline de Fátima Aquino Moreira-Nunes, Raimundo Miranda de Carvalho, Paulo P. Assumpção, Juan A. Rey, Rommel M. Rodríguez Burbano

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Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease by Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang

“…Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Exosomes facilitate the transfer and exchange of proteins and specific nucleic acids, thereby playing a significant role in intercellular communication. …”
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Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications by Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song

“…Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids. Emerging studies have reported various roles of OMVs in bacterial virulence, antibiotic resistance, stress adaptation, and host interactions, whereas knowledge on their roles in K. pneumoniae is currently unclear. …”
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Application of metagenomic next-generation sequencing in the diagnosis of post-stroke infections: a case series study using multiple sample types by Xiaopu Chen, Yong Liang, Wei Yang, Wenzhen He, Zhiqiang Xing, Shunxian Li, Shaoyu Cai, Jiping Fu, Xiaotang Peng, Manli Chen, Jiaming Wu

“…BackgroundMetagenomic high-throughput sequencing (mNGS) represents a powerful tool for detecting nucleic acids from various pathogens, such as bacteria, fungi, viruses and parasites, in clinical samples. …”
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