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461
The Redox System in C. elegans, a Phylogenetic Approach
Published 2012-01-01“…ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role of ROS in cellular damage is frequently all that is noted, ROS are also important in redox signalling. …”
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462
DETERMINATION OF INFECTIOUS DISEASESBY POLYMERASE CHAIN REACTION
Published 2024-09-01“…This research studies will identify active infections such as arboviruses, sexually transmitted diseases and bacterial infections through the identification of infectious agents and nucleic acids via PCRs methods. There must be stronger molecular science to enhance infectious agent detection capabilities to track the spread of infectious diseases and take appropriate measures to support patients and the health workers themselves. …”
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463
Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis
Published 2024-12-01“…Sweat contains numerous vital biomarkers such as metabolites, electrolytes, proteins, nucleic acids and antigens that reflect hydration status, exhaustion, nutrition, and physiological changes. …”
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464
Engineering extracellular vesicles for ROS scavenging and tissue regeneration
Published 2024-06-01“…EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. …”
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465
Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease
Published 2025-02-01“…Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. …”
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466
Recent advancements in Point-of-Care Detection of Contaminants and Biomarkers in Human Breast Milk: A comprehensive review
Published 2025-06-01“…It contains amino acids, nucleic acids and the essential immunological components required for the neonate to survive. …”
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467
Recent advances in polymeric nanoparticles for the treatment of hepatic diseases
Published 2025-01-01“…Furthermore, this paper reviewed the application of polymeric nanoparticles -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) and poly (lactic-co-glycolic acid) (PLGA)-in liver disease treatment, focusing on their use in various delivery systems for pure bioactive compounds of natural origin, drugs, nucleic acids, peptides, and others. Finally, the challenges and future perspectives of the NPs were discussed to provide guidance for further research directions, with the aim of promoting the clinical application of nanotherapeutics in treating hepatic diseases.…”
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468
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Published 2011-01-01“…At a first glance, ribosome biogenesis and chromatin remodeling are quite different processes, but they share a common problem involving interactions between charged nucleic acids and small basic proteins that may result in unwanted intracellular aggregations. …”
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469
Extracellular vesicles—a new player in the development of urinary bladder cancer
Published 2025-01-01“…EVs can transport proteins, lipids, or nucleic acids to specific target cells. What brings more attention and potential implications is the fact that cancer cells secrete more EVs than non-malignant cells. …”
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470
Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Published 2016-01-01“…Stem cells, as well as most cells, release extracellular vesicles such as exosomes, which are nanovesicles able to target specific cell types and thus to modify their function by delivering proteins, lipids, and nucleic acids. Exosomes have recently been tested in vivo and in vitro as therapeutic conveyors for the treatment of diseases. …”
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471
Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets
Published 2023-04-01“…Abstract Biomolecular condensates are cellular structures composed of membraneless assemblies comprising proteins or nucleic acids. The formation of these condensates requires components to change from a state of solubility separation from the surrounding environment by undergoing phase transition and condensation. …”
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472
Identification of nine mammal monosaccharides by solid-state nanopores
Published 2024-12-01“…Abstract Glycans, nucleic acids and proteins are three major classes of natural biopolymers. …”
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473
Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets
Published 2025-01-01“…Recent discoveries have highlighted the crucial role of biomolecular condensates—membrane-less assemblies formed through the condensation of proteins, nucleic acids, and other molecules—in driving efficient and dynamic cellular processes. …”
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474
Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis
Published 2025-01-01“…They facilitate communication and signalling between cells by transferring a variety of biological substances, such as proteins, lipids, and nucleic acids like mRNA and miRNA. Exosomal miRNAs were shown to be involved in normal and pathological conditions. …”
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475
PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia
Published 2020-01-01“…We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the t(15;17) and t(9;22) translocations in the leukemic cells. Preserved nucleic acids from routine BCR-ABL1 testing provided a unique opportunity to evaluate clonal progression over time. …”
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476
Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids
Published 2015-01-01“…Nickel is also present in nucleic acids, though its function in DNA or RNA is still not clearly understood. …”
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477
Emerging roles of extracellular vesicles in oral and maxillofacial areas
Published 2025-02-01“…Present in various body fluids and tissues, they act as messengers via the transfer of nucleic acids, proteins, and metabolites to recipient cells. …”
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478
Exosomes in Ocular Health: Recent Insights into Pathology, Diagnostic Applications and Therapeutic Functions
Published 2025-01-01“…Exosomes are extracellular vesicles ranging from 30 to 150 nm in diameter that contain proteins, nucleic acids and other molecules. Produced by virtually all cell types, they travel throughout the body until they reach their target, where they can trigger a wide variety of effects by transferring the molecular cargo to recipient cells. …”
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479
Gene Polymorphisms of the antioxidant enzymes NOX, GSTP, and GPX and diabetic nephropathy risk in Saudi patients with type 2 diabetes
Published 2024-12-01“…Hyperglycaemia-mediated increases in free radicals have a deleterious effect on cellular compartments and nucleic acids, leading to imbalances between free radicals and antioxidant enzymes. …”
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480
Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications
Published 2025-03-01“…Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g., proteins and nucleic acids), enables to target the entire molecule through recognizing partial epitopes exposed on it, greatly expanding the applicability and simplifying synthesis process of molecularly imprinted polymers (MIPs). …”
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