Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules by Yang Gao, Jiexun Bu, Zhou Peng, Biwei Yang

“…Due to the extensively studied peptide fragmentation, this review focuses only on nonpeptide biomolecules such as nucleic acids, carbohydrates, and phospholipids.…”
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Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems by Yuxuan Liu, Yaohui Ou, Linlin Hou

“…Nucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, and drug development. …”
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Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…However, the delivery of nucleic acids to the central nervous system (CNS) by the systemic route, remains a major hurdle. …”
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CRISPR/Cas Enzyme Catalysis in Liquid–Liquid Phase‐Separated Systems by Yaqin Zhang, Jianai Chen, Zhina Wu, Chenfei Zhao, Rui Wang, Zhiping Li, Jiasi Wang, Di Wang

“…The findings revealed that nucleic acids and proteins tended to be distributed in the dextran‐rich phase. …”
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Phosphoryl guanidine oligonucleotides as primers for RNA-dependent DNA synthesis using murine leukemia virus reverse transcriptase by E. S. Dyudeeva, I. A. Pyshnaya

“…The best-known completely uncharged analogs of oligonucleotides – morpholine oligonucleotides and peptide nucleic acids – cannot be substrates for enzymes that process nucleic acids. …”
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Evaluation of a Commercial Multiplex Real-Time PCR with Melting Curve Analysis for the Detection of <i>Mycobacterium tuberculosis</i> Complex and Five Nontuberculous Mycobacterial... by Keun Ju Kim, Yunhee Chang, Seung Gyu Yun, Myung-Hyun Nam, Yunjung Cho

“…Results: The NeoPlex assay successfully detected nucleic acids in 87 of the 91 isolates (95.6%). Notably, it identified additional mycobacterial nucleic acids not detected by the LPA in eight isolates. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…IntroductionThe functionalization of nanoparticles (NPs) with an antiCD19 targeting mechanism represents a promising approach for the selective delivery of drugs and nucleic acids into normal and tumor B cells. This strategy has the advantage of minimizing off-target effects by restricting gene delivery to the desired cell population. …”
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Viruses Seen by Our Cells: The Role of Viral RNA Sensors by Elias A. Said, Nicolas Tremblay, Mohammed S. Al-Balushi, Ali A. Al-Jabri, Daniel Lamarre

“…These receptors have the capacity to sense the presence of viral nucleic acids as pathogen-associated molecular patterns (PAMPs). …”
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Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases by João Henrique Campos, Rodrigo Pedro Soares, Kleber Ribeiro, André Cronemberger Andrade, Wagner Luiz Batista, Ana Claudia Torrecilhas

“…Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. …”
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Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment by Liu Hanqing, Tu Zhigang, Feng Fan, Shi Haifeng, Chen Keping, Xu Ximing

“…Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. …”
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Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke by Yongdan Cun, Yaju Jin, Danli Wu, Li Zhou, Chengcai Zhang, Simei Zhang, Xicheng Yang, null Zuhong Wang, Pengyue Zhang

“…Exosomes are the heterogeneous population of extracellular vesicles which play critical roles in intercellular communication through transmitting various proteins and nucleic acids to nearby and distant recipient cells by body fluids and circulation. …”
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Effects of B9 and B12 vitamins deficiency on the genesis of megaloblastic anemia by Karen Aracelly Tobar Armendariz, Silvia Tatiana Tite Andi

“…Vitamins B9 and B12 participate in the normal synthesis of nucleic acids, being directly involved in the synthesis of purines and pyrimidines, as well as cell maturation. …”
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Potential for Isolation of Immortalized Hepatocyte Cell Lines by Liver-Directed In Vivo Gene Delivery of Transposons in Mice by Masahiro Sato, Issei Saitoh, Emi Inada, Shingo Nakamura, Satoshi Watanabe

“…Here, we proposed that a combination of transposon- and liver-directed introduction of nucleic acids may confer acquisition of unlimited cellular proliferative potential on hepatocytes, enabling the possible isolation of immortalized hepatocyte cell lines, which has often failed using more traditional immortalization methods.…”
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Specific Viruses Detected in Nigerian Children in Association with Acute Respiratory Disease by Oluwabukola M. Akinloye, Esa Rönkkö, Carita Savolainen-Kopra, Thedi Ziegler, Bamidele A. Iwalokun, Mope A. Deji-Agboola, Afolabi Oluwadun, Merja Roivainen, Festus D. Adu, Tapani Hovi

“…Validated real-time RT-PCR techniques revealed nucleic acids of at least one virus group in 189 specimens (77%). …”
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Human Breast Carcinomal Tissues Display Distinctive FTIR Spectra: Implication for the Histological Characterization of Carcinomas by Tiyu Gao, Jun Feng, Yunxiang Ci

“…Some distinctive spectral differences which are mainly due to nucleic acids and proteins are observed between normal and carcinomal tissues. …”
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Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective by Wuzhen Chen, Jingxin Jiang, Wenjie Xia, Jian Huang

“…Exosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids. These vesicular organelles play a key role in intercellular communication. …”
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Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease by Jiangyuan Jin, Mianzhi Zhang

“…Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. …”
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Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. This review delves into the factors influencing the properties of EVs, such as temperature and stress conditions, which collectively influence their size, composition, and functional attributes. …”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biotherapeutics tend to be big, bulky, polar molecules comprised of protein and/or nucleic acids. Compared to their small molecule counterparts, they are fragile, labile, and heterogeneous. …”
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The unexpected role of the STING protein in lipid metabolism by Vila, Isabelle K., Laguette, Nadine

“…Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. …”
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