Multifocal Tuberculous Osteomyelitis of Ribs with Active Pulmonary Infection by Venkatesh Elumalai, K. Krishnamoorthy, T. Joseph Pratheeban, E. Mathan, O. M. Rahman Shahul Hameed

“…Pus was aspirated from chest wall swelling detected mycobacterium TB in Catridge based nucleic acid amplification test, and the patient was started on antitubercular therapy. …”
Get full text

Mycoplasma genitalium: An Emerging Sexually Transmitted Infection by Jessian L. Munoz, Oluwatosin Jaiyeoba Goje

“…M. genitalium is a slow growing organism, and, with the advent of nucleic acid amplification test (NAAT), more studies are being performed, and knowledge about the pathogenicity of this organism elucidated. …”
Get full text

Acute Myopericarditis Likely Secondary to Disseminated Gonococcal Infection by Daniel Bunker, Leslie Dubin Kerr

“…Though gonococcal infection was never proven with culture or nucleic acid amplification testing, the clinical picture and histologic findings were highly suggestive of DGI. …”
Get full text

Researches on ovine adenavirus type three (oa<sub>3</sub>) isolated from clinically healthy sheep in turkey by Feridun ÖZTÜRK

“…<p> Isolated virus was alsa able to multiply in cattle originated cells besides the sheep originated ones and the type of its nucleic acid was DNA. According to measurements made by electronmicroscope its length was alıout 100 milimicron. …”
Get full text

CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma by Jiaojiao Xu, Zhe Li, Qinli Tong, Sihang Zhang, Jianchen Fang, Aihua Wu, Guoguang Wei, Chen Zhang, Sheng Yu, Binbin Zheng, Hongzheng Lin, Xueling Liao, Zeyu Xiao, Wei Lu

Get full text

Suitability of Commercial Transport Media for Biological Pathogens under Nonideal Conditions by Kyle Hubbard, Gregory Pellar, Peter Emanuel

“…The results demonstrate that COTS media, although sufficient for the preservation of nucleic acid and proteinaceous material, are not capable of maintaining an accurate representation of biothreat agents at the time of collection.…”
Get full text

Antiviral Activity of Resveratrol against Human and Animal Viruses by Yusuf Abba, Hasliza Hassim, Hazilawati Hamzah, Mohamed Mustapha Noordin

“…Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. …”
Get full text

Gene Expression in Aphelid Zoospores Reveals Their Transcriptional and Translational Activity and Alacrity for Invasion by Igor R. Pozdnyakov, Alexei O. Seliuk, Kristina O. Barzasekova, Sergey A. Karpov

“…Among the highly expressed genes with known functions, the largest functional categories were “Cellular Metabolism”, “Protein Synthesis”, “Cell State Control”, and “Nucleic Acid Processing”. Unlike fungal zoospores, translational and transcriptional activity was demonstrated for <i>A. insulamus</i> zoospores. …”
Get full text

Targeting Toll-Like Receptors for Treatment of SLE by Christopher G. Horton, Zi-jian Pan, A. Darise Farris

“…Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. …”
Get full text

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Interestingly, B cells also express some innate sensors, like TLR7 and TLR9, and may respond to bacterial hypomethylated CpG motifs and single-stranded RNA viruses. Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE). …”
Get full text

Anti-Retroviral Strategies for AIDS and Related Diseases by Mark A Wainberg, Andre Dascal, Jack Mendelson

“…The replication cycle of human immunodeficiency virus type 1 (HIV-1) and other retroviruses consists of four stages: attachment of the virus to specific receptors on the cell surface; uncoating of the viral nucleic acid and conversion to DNA; production of viral RNA and proteins; and assembly and liberation of progeny virus from the cell. …”
Get full text

Investigation and cause analysis of the psychological status of nursing staff under the normalization of epidemic prevention and control (常态化疫情防控期间护理人员心理状况调查及原因分析)... by ZHAO Jialu (赵佳璐), XIANG Wensheng (相文胜), WANG Huaxin (王华新), DONG Yuxia (董玉霞)

Get full text

Comparison of the STANDARD M10 C. difficile, Xpert C. difficile, and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing Clostridioides difficile infec... by Hyunseul Choi, Minhee Kang, Sun Ae Yun, Hui-Jin Yu, Eunsang Suh, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee

“…This algorithm starts with enzyme immunoassay (EIA) for detecting glutamate dehydrogenase (GDH) and toxins A/B, followed by nucleic acid amplification test (NAAT) for GDH-positive but toxin-negative cases. …”
Get full text

Ionizable polymeric micelles (IPMs) for efficient siRNA delivery by Ziyu Zhou, Yu Feng, Mingzhou Jiang, Zijun Yao, Jing Wang, Feng Pan, Rulan Feng, Chong Zhao, Yinyu Ma, Jinge Zhou, Lei Sun, Xiaotian Sun, Changyou Zhan, Xiao He, Kuan Jiang, Jiahui Yu, Zhiqiang Yan

“…Abstract Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. …”
Get full text

RAPID AND SPESIFIC DETECTION OF MYCOBACTERIUM TUBERCULOSIS USING POLYMERASE CHAIN REACTION by Anita Kurniati, Desak Nyoman Surya Suameitra Dewi, Ni Nyoman Purwani

“…A specific, sensitive, rapid and cheap method for TB and other mycobacteria diagnosis in clinical specimen is a desperate needed in the laboratory diagnosis and hence management of tuberculosis. PCR as one of nucleic acid amplification assays have revolutionized MTB detection. …”
Get full text

Novel Fluorescent Dyes for Single DNA Molecule Techniques by Alexander Zarkov, Aleksey Vasilev, Todor Deligeorgiev, Stoyno Stoynov, Marina Nedelcheva-Veleva

“…To answer the demands of scientific and medical imaging issues, the family of nucleic acid fluorescent dyes is constantly enlarging. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…Although the mechanisms of action are not fully understood, possible explanations are (i) free radical scavenging, (ii) alteration of the tumor cell proliferation by affecting nucleic acid and protein synthesis or inhibition of DNA synthesis, and (iii) hormone regulation. …”
Get full text

Imaging Gene Expression in Regional Brain Ischemia in Vivo with a Targeted [In]-Antisense Radiopharmaceutical by Toyofumi Suzuki, Yun Zhang, Yu-feng Zhang, Felix Schlachetzki, William M. Pardridge

“…The in vivo imaging of decreased GFAP gene expression in cerebral ischemia was examined in the present studies using a targeted peptide nucleic acid (PNA), which was labeled with 111 In, and which hybridized to nucleotides 20–37 of the rat GFAP mRNA. …”
Get full text

Novel Approaches to Diagnose COVID-19 by Solaf Jawhar Ali

“…SARS-CoV-2 can be detected with different methods in the laboratory including real time RT-PCR, chest CT scan and immunoassays. Viral nucleic acid testing has played important role in control COVIDI-19 outbreak.  …”
Get full text

Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China by Haoling Tang, Zhiwei Chen, Tianquan Huang, Pingping Yu, Qiao Tang, Yue Qiu, Yunling Xue, Jing Tang, Nan Cai, Hong Ren, Mingli Peng, Peng Hu

“…The median duration for nucleic acid conversion was 8 days. Forty‐three symptoms were identified during SARS‐CoV‐2 infection (11 symptoms per individual). …”
Get full text