FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy by Liang Zhao, Long Sun, Kaili Fu, Qin Lin, Xiaoyuan Chen, Qicong Luo, Hua Wu, Jianhao Chen, Yangfan Zhou, Yizhen Pang, Guoqiang Su, Haojun Chen

“…We recently reported on a novel dimeric FAP-targeting radiopharmaceutical, 68Ga/177Lu-DOTA-2P(FAPI)2, which demonstrated increased tumor uptake and prolonged retention in various cancers. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…Similarly, in both sexes, decreased alveolar capillarization was also evident in the alcohol-exposed fetal lungs. These data provide novel information in a growing area focused on alcohol effects on the offspring lung and its influence on appropriate fetal/neonatal immune responses and highlights the importance of examining sexual dimorphism in developmental adaptations.…”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…Furthermore, IFFO1 methylation holds great promise as a novel biomarker for the diagnosis and prognosis of PAAD.…”
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A Predictive Model for Pulmonary Aspergillosis in ICU Patients: A Multicenter Retrospective Cohort Study by Li Y, Ren X, Wang Q, Shen S, Li Y, Qian X, Tang Y, Jia J, Zhang H, Ding J, Song Y, Zhang S, Wang S, Xu Y, Jiang Y, He X, Dai M, Zhong L, Xiong Y, Pan Y, Wang M, Shao H, Cai H, Huang L, Wang H

“…Sensitivity and specificity reached 73.1% and 74.9%, respectively, and the model demonstrated good calibration.Conclusion: This study developed a novel risk prediction model for IPA incorporating microbiological characteristics based on clinical metagenomics. …”
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HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in... by Augustine T Choko, Elizabeth L Corbett, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Cheryl C Johnson, Doreen Sakala, Thokozani Kalua, Moses Kumwenda, Richard Hayes, Katherine Fielding

“…We investigated the impact of HIVST alone or with additional interventions on the uptake of testing and linkage to care or prevention among male partners of antenatal care clinic attendees in a novel adaptive trial.<h4>Methods and findings</h4>An adaptive multi-arm, 2-stage cluster randomised trial was conducted between 8 August 2016 and 30 June 2017, with antenatal care clinic (ANC) days (i.e., clusters of women attending on a single day) as the unit of randomisation. …”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Modified neurological severity score (mNSS) was used to evaluate neurological deficit; novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive function; immunofluorescence was used to detect the expression of CD31 in cortex; Western blot was used to detect zonula occludens-1 (ZO-1), Occludin, Claudin-5, phosphorylated nuclear factor kappa-B (p-NF-κB), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), transient receptor potential melastatin-2 (TRPM2), phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthetase kinase-3β (p-GSK3β) protein expression levels.Results(1) Neurological function: compared with the sham surgery group, mNSS in the model group significantly increased at the 1st, 3rd, 5th and 7th day (<italic>P</italic>&lt;0.05); compared with the model group, mNSS in the 24A group significantly decreased at the 3rd and 7th day (<italic>P</italic>&lt;0.05). (2) Cognitive function: compared with the sham surgery group, the NORT recognition index at 1st and 24th hour in the model group was significantly lower (<italic>P</italic>&lt;0.05); compared with the model group, the 1-hour and 24-hour NORT recognition index in the 24A group significantly increased (<italic>P</italic>&lt;0.05). …”
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MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI by Wenbin Lu, Genshan Ma, Zulong Sheng, Qingjie Wang, Lijuan Chen, Junhua Qi, Ronghui Shi, Jingjing Ji, Zhenjun Ji, Qiming Dai

“…Ly6Chigh monocytes are inflammatory cells that accumulate in an infarcted myocardium, and Ly6Clow monocytes are believed to be reparative and curb myocardial remodeling. NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. …”
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Editorial by Christian Gütl

“…We proudly look back on a total of 13 issues - 12 regular and 1 special issue - with 78 articles by 256 authors from 45 countries on novel aspects of various computer science topics. …”
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Selection of Superior Sugar Beet Genotypes using the Analysis of Quantitative and Qualitative Traits by Mahdi Hassani, Ali Saremirad, Hamed Mansouri

“…Methods: This research was conducted on 49 meticulously chosen sugar beet genotypes, comprising 44 novel hybrids and five control varieties, encompassing three domestic and two foreign cultivars. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…By framing the deliberate dismantling of Gaza’s education sector within a genocidal context, the paper offers a novel perspective on the intersection of conflict, education and cultural preservation. …”
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Investigating the Nature of Orientalism from a Philosophical-Historical Point of View Based on the Relationship between Subject and Object by Ghorban Elmi, Alireza Nahri

“…The nature of Orientalism could be located in this novel relationship between the subject and the object of knowledge. …”
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Neurotoxicity of aluminium chloride and okadaic acid in zebrafish: Unravelling Alzheimer's disease model via learning and memory function evaluation by S.Z. Raduan, Q.U. Ahmed, M.R.A. Rusmili, A.S.M. Sabere, M.S. Haris, M.F. Shaikh, W.A.W. Sulaiman, M.H. Mahmood

“…The behavioural tasks consisted of a novel tank test lasting 6 min, followed by a T-maze tank test lasting 5 min. …”
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Mitral Valve Repair by Irbaz Hameed, MD, Adham Ahmed, BS, Christina Waldron, BS, Percy T. Algarate, MD, Michal Kawczynski, MD, Maurish Fatima, MBBS, BS, Amnah Alhazmi, MBBS, Samantha Colon, BS, Alexandria Brackett, MA, MLIS, Samuel Heuts, MD, PhD, Peyman Sardari Nia, MD, PhD, Mario Gaudino, MD, PhD, Vinay Badhwar, MD, Arnar Geirsson, MD

“…The primary outcomes were long-term survival, freedom from reoperation, and freedom from recurrent mitral regurgitation (moderate-severe). A novel meta-analytic volume-outcome approach using reconstructed Kaplan-Meier-derived individual patient data from the original studies was used. …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Here, we present Non-lethal Sonodynamic Therapy (NL-SDT), in which ultrasound is used to activate locally sonosensitizers, thereby stimulating the production of reactive oxygen species for the purpose of modulating cell function or fate, as a novel methodology to inhibit progression of hypertensive renal fibrosis. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…Drawing on social network and political participation theory and novel survey data from Belgium, Paulis explores what network patterns contribute to young people’s enrolment in a political party. …”
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BDC-DAL: A new algorithm using blueprint difference convolution and dual auxiliary supervision for lightweight face anti-spoofing(BDC-DAL：基于蓝图差分卷积和双重辅助监督的轻量化人脸活体检测算法)... by 叶继华(YE Jihua), 梁芳昕(LIANG Fangxin), 王超(WANG Chao), 肖顺杰(XIAO Shunjie), 宗义(ZONG Yi), 江爱文(JIANG Aiwen)

“…To overcome these challenges, this paper proposes a lightweight face anti-spoofing method based on blueprint difference convolution and dual auxiliary supervision (BDC-DAL). This novel approach effectively reduces the parameters and computation of the model by combining a lightweight convolutional structure and blueprint difference convolutional design, while retaining the ability to capture complex fine-grained features. …”
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'Contrafacta': le chant, les timbres, la romance et les conditions de la poésie au tournant des Lumières by Martin Wåhlberg

“…French poetry from this period has long suffered from a lack of scholarly interest. The novel – and, more recently, drama – has been at the centre of French Enlightenment studies, and the massive poetic production from this period has only rather recently attracted serious attention. …”
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MSH-YOLOv8: Mushroom Small Object Detection Method with Scale Reconstruction and Fusion by YE Dapeng, JING Jun, ZHANG Zhide, LI Huihuang, WU Haoyu, XIE Limin

“…To address the issue of maintaining high accuracy amid changes in image size and target scale, a novel detection model, Multi-Strategy Handling YOLOv8 (MSH-YOLOv8), was proposed.…”
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Scrutinizing Generation Z's Interpretation of Social Justice: A Case Study in Khomeinishahr, Iran by Akbar Zareshahabadi, Alireza Asgari, Reza Javadian

“…In conclusion, Generation Z informed by their experiences with discrimination and existing definitions of social justice presented a novel and eclectic interpretation that blended elements of equality and meritocracy. …”
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Investigating and Completing Khanlari’s Theory on Metrical Units by Abbas Jahed Jah

“…This study demonstrates that by completing and refining Khanlari’s approach, it is capable of describing Persian poetic meter, providing a novel understanding of the nature of metrical patterns, and can aid in simplifying the teaching of prosody while deepening its comprehension. …”
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