Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts by Kelley Weinfurtner, David Tischfield, George McClung, Jennifer Crainic, John Gordan, Jing Jiao, Emma E. Furth, Wuyan Li, Erena Tuzneen Supan, Gregory J. Nadolski, Stephen J. Hunt, David E. Kaplan, Terence P.F. Gade

“…Leveraging xenograft tumors derived from patients with unresectable HCCs and a commercially available immunodeficient mouse strain that expresses human GM-CSF and IL-3, we demonstrate a novel but accessible approach for modeling the HCC tumor microenvironment.…”
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Spatial heterogeneity determines the gastrointestinal microbiome signatures and ecological processes that govern bacterial community assembly in sheep by Yukun Zhang, Jiangbo Cheng, Changchun Lin, Fadi Li, Xiaoxue Zhang, Chong Li, Deyin Zhang, Xiaobin Yang, Dan Xu, Yuan Zhao, Liming Zhao, Xiaolong Li, Huibin Tian, Xiuxiu Weng, Weimin Wang

“…This study enhances our understanding of microbial coexistence and interactions in complex ecosystems, with implications for improving animal productivity, disease treatment, and the development of novel microbial formulations.…”
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Clinical analysis of microscopic modified ostium obstruction surgery for symptomatic sacral Tarlov cysts by HUANG Qin‐guo, WU Yan‐yu, LI Hong, ZHOU Qiang, PENG Lin, LU Yun‐tao

“…Accordingly, we present a novel method of cysts separation and ostium closure that aims to block the ostium more firmly and reliably. …”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Subsequently, we made a novel discovery that ZC3H15 knockdown mice with BCP displayed improved neuronal oxidative stress and reactive oxygen species (ROS) generation in spinal cord tissues, which was confirmed in H2O2-treated mouse spinal cord neurons primarily through mediating the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor, erythroid 2-like transcription factor 2 (NRF2) pathway. …”
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DEVELOPMENT AND EVALUATION OF AN ANTERIORLY MOUNTED MICROPROCESSOR-CONTROLLED POWERED HIP JOINT PROSTHESIS by Kelly Brannen, Natalie Baddour, Lucas Cho, David Langlois, Patrick Dumond, Edward Lemaire

“…For each participant, hip angles and stride parameters during level walking were assessed by analyzing five gait cycles. FINDINGS: The novel PHP met most of the design criteria; however, it protruded 56 mm anteriorly from the lamination plate, exceeding the specified criterion of 20 mm. …”
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The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer by Yao Yi, Yao Yi, Yu Zhong, Yu Zhong, Lianhua Xie, Lianhua Xie, Shuxian Lu, Shuxian Lu, Yifeng Zhang, Yifeng Zhang

“…Therefore, there is an urgent need to discover novel and targeted therapeutic strategies, particularly those focusing on the immune infiltrate in TNBC, to enhance diagnosis and prognosis for affected individuals.MethodsThe gene co-expression network and gene ontology analyses were used to identify the differential modules and their functions based on the GEO dataset of GSE76275. …”
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Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…These outlets play a pivotal role in the worldwide dissemination of novel medical knowledge. However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine. …”
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Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal by Mamadou Malado Jallow, Moussa Moise Diagne, Marie Henriette Dior Ndione, Mamadou Aliou Barry, Ndiendé Koba Ndiaye, Davy Evrard Kiori, Marie Pedapa Mendy, Déborah Goudiaby, Gamou Fall, Malick Fall, Ndongo Dia

“…Therefore, as part of the “One Health” approach to influenza surveillance, we conducted active AIV surveillance in two live bird markets (LBMs) in Dakar to better understand the dynamics and diversity of influenza viruses in Senegal, obtain genetic profiles of circulating AIVs, and assess the risk of emergence of novel strains and their transmission to humans. Cloacal swabs from poultry and environmental samples collected weekly from the two LBMs were screened by RT-qPCR for H5, H7, and H9 AIVs. …”
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Spatiotemporal analysis of rainfall and temperature variability and trends for a mixed crop-livestock production system: its implications for developing adaptation strategies by Sintayehu Alemayehu, Daniel Olago, Opere Alfred, Tadesse Terefe Zeleke, Sintayehu W. Dejene

“…By integrating these methods with global SST data and atmospheric pressure systems, the research delivers a nuanced understanding of how global climatic factors influence local weather patterns. The study’s novel approach not only identifies key trends and patterns in climate variables over an extensive historical period but also links these findings to practical outcomes in crop and livestock production. …”
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Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling by Zhao Z, Chen T, Liu Q, Hu J, Ling T, Tong Y, Han Y, Zhu Z, Duan J, Jin Y, Fu D, Wang Y, Pan C, Keyoumu R, Sun L, Li W, Gao X, Shi Y, Dou H, Liu Z

“…Zihe Zhao,1,* Taicai Chen,2,3,* Qingyuan Liu,4 Jianhang Hu,1 Tong Ling,2,3 Yuanhao Tong,5 Yuexue Han,1 Zhengyang Zhu,6 Jianfeng Duan,7 Yi Jin,1 Dongsheng Fu,1 Yuzhu Wang,1 Chaohui Pan,1 Reyaguli Keyoumu,1 Lili Sun,1 Wendong Li,1 Xia Gao,8,9 Yinghuan Shi,2,3 Huan Dou,10,11 Zhao Liu1 1Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2The State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, People’s Republic of China; 3National Institute of Healthcare Data Science, Nanjing University, Nanjing, People’s Republic of China; 4Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Department of Thoracic Surgery, BenQ Medical Center, Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 6Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 7Department of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 8Department of Otolaryngology, Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 9Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 10The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, People’s Republic of China; 11Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhao Liu, Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, #321 Zhongshan Road, Nanjing, 210008, People’s Republic of China, Email liuzhao@nju.edu.cn Huan Dou, The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, People’s Republic of China, Email douhuan@nju.edu.cnPurpose: Stanford Type B Aortic Dissection (TBAD), a critical aortic disease, has exhibited stable mortality rates over the past decade. …”
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Economic burden of breast cancer in India, 2000–2021 and forecast to 2030 by Rakesh N Pillai, Aleena Alex, Narassima M.S., Vivek Verma, Ajil Shaji, Keechilat Pavithran, D. K. Vijaykumar, Denny John

“…This study introduces a novel approach to forecasting the number of breast cancer cases (based on prevalence rates) and estimating the associated economic impact in India using the autoregressive integrated moving average (ARIMA) model. …”
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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

“…Methods We developed ClinOps, a novel 10-week clinical trial operations training program for study coordinators in Africa to enhance their expertise in four fundamental areas: designing, conducting, managing, and reporting clinical trials. …”
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IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…They should be adopted in the immediate future. In addition, novel drug delivery strategies are developed. Therefore, the aim of pathogenically-based treatment using modern therapeutic agents is to save maximum vision and the quality of life in most patients.…”
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Éloge de l’inauthenticité: le dix-huitième siècle à l’écran, autour de 'Barry Lyndon' de Stanley Kubrick by Alexis Tadié

“…If Kubrick appears in Barry Lyndon to strive for perfection through immersion in the Enlightenment, he also keeps his distance from the period, especially by re-establishing the relationship between Thackeray’s original novel and his own adaptation. I emphasise that the viewer’s essential awareness of cinematic construction creates an effect of distance from, as well as immersion in, the eighteenth century. …”
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Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring by Flynn S, Mosher CL, Cornelison S, Rao E, Metzler KA, Pu W, Davies J, Paladenech C, Doyle D, MacIntyre N, Ohar J

“…This study evaluated the feasibility and usability of a novel home-based, virtual PR (V-PR) intervention compared to center-based PR (C-PR). …”
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Intelligent recognition algorithm and application of coal mine overhead passenger device based on multiscale feature fusion by Beijing XIE, Heng LI, Hang DONG, Zheng LUAN, Ben ZHANG, Xiaoxu LI

“…In the feature extraction stage, the partial convolution of the backbone network C2f module is replaced by deformable convolution, and a novel C2f_DCN module is designed. This enhancement increased the dynamic adjustment capability of the target receptive field for cmopd with different passenger-carrying statuses, allowing the model to capture different scale information and better learn the coupled features of cmopd and miners. …”
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Detection Method of Apple Alternaria Leaf Spot Based on Deep-Semi-NMF by FU Zhuojun, HU Zheng, DENG Yangjun, LONG Chenfeng, ZHU Xinghui

“…There is an urgent need to develop new methods for detecting apple Alternaria leaf spot, which can assist in the precise prevention and control of apple tree diseases.[Methods]A novel detection method named Deep Semi-Non-negative Matrix Factorization-based Mahalanobis Distance Anomaly Detection (DSNMFMAD) was proposed, which combines Deep Semi-Non-negative Matrix Factorization (DSNMF) with Mahalanobis distance for robust anomaly detection in complex image backgrounds. …”
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

“…Background & Aims: We compared the clinical performance of the novel GAAD (gender [biological sex], age, alpha-fetoprotein [AFP], des-gamma carboxyprothrombin [DCP]) and GALAD (gender [biological sex], age, AFP, Lens culinaris agglutinin-reactive AFP [AFP-L3], DCP) algorithms to deduce the clinical utility of AFP-L3 for detecting early-stage hepatocellular carcinoma (HCC) from chronic liver disease (CLD). …”
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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…Conventional treatment modalities, including radiation and chemotherapy, often fall short of achieving complete remission, highlighting the critical need for novel therapeutic strategies. One promising approach involves the oncolytic potential of Group A <i>Streptococcus</i> (GAS) strains for tumor treatment. …”
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Palette-based image recoloring based on moving least squares(基于移动最小二乘的图像重着色) by 周家伟(ZHOU Jiawei), 黄子康(HUANG Zikang), 彭俊豪(PENG Junhao), 李盛善(LI Shengshan), 刘晓静(LIU Xiaojing), 杜正君(DU Zhengjun)

“…Addressing this issue, this paper introduces a novel image recoloring algorithm based on moving least squares, significantly enhancing the locality and precision of color editing. …”
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