Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…The combination of CM272 with immunotherapy offers a novel, effective treatment strategy for PDAC.…”
Get full text

A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Abstract Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment. …”
Get full text

Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…Furthermore, this research is exploratory in nature, as it aims to design a model on a novel and innovative topic. Methods A mixed qualitative-quantitative method was employed in this study. …”
Get full text

Unity in diversity: navigating global connections through cultural exchange by Dwi Mariyono, Annis Nur Alifatul Kamila, Akmal Nur Alif Hidayatullah

“…Originality/value – This study’s originality lies in its methodological triangulation, using HTCA as a novel approach to unify content and thematic insights. …”
Get full text

To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Finally, qRT_PCR and WB results showed that ATP2A3, AEBP1, PNMA1, and PLAT were highly expressed in liver cancer tissue compared to adjacent tissue, and the proliferation, migration, and invasion of HCCLM3 cells were inhibited after knocking out AEBP1. We constructed novel risk score models as prognostic biomarkers for HCC, which has the potential to guide the development of more personalized treatment strategies for HCC patients. …”
Get full text

Roles of the rpoEc-chrR-chrA operon in superoxide tolerance and β-lactam susceptibility of Stenotrophomonas maltophilia by Ren-Hsuan Ku, Hsu-Feng Lu, Li-Hua Li, Li-Hua Li, Ting-Yu Yeh, Yi-Tsung Lin, Yi-Tsung Lin, Tsuey-Ching Yang

“…Deletion of smlt2375-smlt2367 cluster from the chromosome of KJΔChrR reverted the superoxide tolerance and β-lactam susceptibility to the wild-type level.DiscussionThe rpoEc-chrR pair of S. maltophilia was involved in superoxide tolerance and β-lactam susceptibility. Notably, a novel regulatory circuit involving rpoEc-chrR-chrA operon and smlt2375-smlt2367 cluster was revealed.…”
Get full text

Tools for the Analysis of Quantum Protocols Requiring State Generation Within a Time Window by Bethany Davies, Thomas Beauchamp, Gayane Vardoyan, Stephanie Wehner

“…Since it is difficult to obtain general closed-form expressions for statistical quantities describing the expected waiting time <inline-formula><tex-math notation="LaTeX">$\mathbb {E}(\tau _{(w,s)})$</tex-math></inline-formula> and the distribution <inline-formula><tex-math notation="LaTeX">$X_{(w,s)}$</tex-math></inline-formula>, we present two novel results that aid their computation in certain parameter regimes. …”
Get full text

Comparative evaluation of antifungal susceptibility testing methods of invasive Candida species and detection of FKS genes mutations in caspofungin intermediate and resistant isola... by Dalia Saad ElFeky, Doaa Mahdy El-Wakil, Mai M. Mwafy, Mohamed M.A. Atia, Noha Mahmoud Gohar

“…Conclusions ATB FUNGUS 3 demonstrated acceptable performance for AFST, however, azole activity against Candida spp. should be interpreted carefully. Novel mutations within HS regions of FKS genes elucidated different levels of caspofungin resistance in C. glabrata and C. parapsilosis isolates.…”
Get full text

RETRACTED: Long non‐coding RNA Sox2OT promotes coronary microembolization‐induced myocardial injury by mediating pyroptosis by Liying Xuan, Danni Fu, Dong Zhen, Dongsong Bai, Lijun Yu, Guohua Gong

“…This investigation may provide novel insights for the treatment of CME‐induced MI.…”
Get full text

Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…The Hemoglobin A1c/High-Density Lipoprotein Cholesterol (HbA1c/HDL-C) ratio, an integrated marker of glycolipid homeostasis, may serve as a novel predictor of stroke risk. Methods Our investigation utilized data from the China Health and Retirement Longitudinal Study cohort (2011–2018). …”
Get full text

Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Probiotic supplementation could offer a novel early intervention strategy for AD, highlighting the pivotal role of gut health in neurodegeneration.…”
Get full text

The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases by Yezhou Ding, Mingyang Feng, Wanqing Chi, Xiaoyin Wang, Baoyan An, Kehui Liu, Shike Lou, Xiaolin Wang, Hui Wang

“…Conclusions METTL17 may serve as a novel prognostic marker and therapeutic target for human tumors, offering a theoretical foundation for formulating more effective and tailored clinical treatment options for cancers, particularly HCC.…”
Get full text

Deep learning-based CT-free attenuation correction for cardiac SPECT: a new approach by Pei Yang, Zeao Zhang, Jianan Wei, Lisha Jiang, Liqian Yu, Huawei Cai, Lin Li, Quan Guo, Zhen Zhao

“…Conclusion We propose a novel DL-based CT-free AC approach for cardiac SPECT, which can generate AC images without the need for a CT scan. …”
Get full text

Spirituality-based palliative care education on quality of life, death anxiety, and resilience of heart failure patients: Randomized controlled clinical trial by Roghayeh Balaghi Inaloo, Mostafa Bijani, Leila Nikrouz, Azizallah Dehghan, Abdulhakim Alkamel, Ali Taghinezhad, Zahra Khiyali

“…We recommend that healthcare administrators implement this novel educational approach in the care of heart failure patients.…”
Get full text

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…Abstract Background Because of their many bioactivities, which include psychoanalytic, antifungal, antihypertensive, anti-inflammatory, and antiviral properties, pyrazoles and their derivatives are attracting interest in pharmacology and medicine, the pressing need for novel fungicides is increased for lessened by the growing microbiological resistance of illnesses to recognized antibiotics. …”
Get full text

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…To address these unresolved questions, we employed a novel and highly controlled approach utilizing long-term cultivated BV-2 microglia, exempted from additional external stimuli. …”
Get full text

Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals by Ming Jiao, Jiaoli Chen, Xiaoling Wang, Wenyu Tao, Yunhua Feng, Huijun Yang, Haiying Yang, Shanshan Zhao, Ying Yang, Yiping Li

“…Anthropometric and metabolic parameters were detected. Novel insulin resistance indices, such as lipid accumulation product (LAP) was calculated. …”
Get full text

Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats by Yang CT, Shyu BC, Lin WT, Lu KH, Lin CR, Wen YR, Chen CC

“…To elucidate the mechanism of action among conventional and current novel types of SCSs, a stable and reliable electrophysiology model in the consensus animals to mimic human SCS treatment is essential. …”
Get full text

Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

Get full text

Positively charged polysilsesquioxane/iodide lonic liquid as a quasi solid-state redox electrolyte for dye-sensitized photo electrochemical cells: infrared, <mml:math alttext="$^{{...

“…<p>A new sol-gel precursor based on 1-methyl-3-[3-(trimethoxy-<mml:math alttext="$lambda^4$"> <mml:mrow> <mml:msup> <mml:mi>&#x03BB;</mml:mi> <mml:mn>4</mml:mn> </mml:msup> </mml:mrow> </mml:math>-silyl)propyl]-1<mml:math alttext="$H$"> <mml:mi>H</mml:mi> </mml:math>-imidazolium iodide (MTMSPI<mml:math alttext="$^+I^-$"> <mml:mrow> <mml:msup> <mml:mi></mml:mi> <mml:mtext>+</mml:mtext> </mml:msup> <mml:msup> <mml:mtext>I</mml:mtext> <mml:mo>&#x2212;</mml:mo> </mml:msup> </mml:mrow> </mml:math>) was synthesized and investigated as a potential novel quasi solid-state ionic liquid redox electrolyte for dye-synthesized photoelectrochemical (DSPEC) cells of the Graetzel type. …”
Get full text