A Case Study Identified a New Mutation in the TTN Gene for Inherited Hypertrophic Cardiomyopathy by Dong J, Liu M, Chen Q, Zha L

“…Candidate variants obtained by WES were verified using Sanger sequencing, pathogenic mutation screening was conducted among family members, and the mutations were systematically analyzed using bioinformatics.Results: WES revealed a novel heterozygous missense mutation, c.20233 C>T (p.R6745C), located in exon 80 of the HCM-related gene TTN, which may be a pathogenic mutation in the family. …”
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Evaluating Reaction Videos of Young People Watching Edutainment Media (MTV Shuga): Qualitative Observational Study by Venetia Baker, Sarah Mulwa, David Khanyile, Georgia Arnold, Simon Cousens, Cherie Cawood, Isolde Birdthistle

“…We trialed reaction videos as a novel research method to investigate how young people in South Africa experience the show, including sexual health themes and messages, in their viewing environments. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…The use of 3-TYP further confirmed FBR2’s intervention in ferroptosis and cellular senescence through the SIRT3/p53 pathway.ConclusionFBR2 shows therapeutic potential in a BLM-induced pulmonary fibrosis mouse model, with its effects mediated through modulation of the ferroptosis pathway via the SIRT3/p53 mechanism. This study provides novel evidence for the targeted treatment of IPF and offers further insights into its pathogenesis.…”
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Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2 by An W, Luo J, Zhang C, Xiao Q

“…Functional studies also suggest a functional role of PTGS2 in ferroptosis and AAD development, offering novel insights into pathogenesis of human AAD.Keywords: aortic aneurysm and dissection, PTGS2, macrophage, ferroptosis, integrative bioinformatics analysis…”
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USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…This study highlights the potential of sEVs-loaded scaffolds as a promising strategy for scarless vaginal repair following vaginoplasty, offering a novel approach for regenerative medicine with significant translational potential for clinical application. …”
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…Thus, UC-MSCs may serve as a novel therapeutic agent for T2DM patients with NAFLD.…”
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Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer by Wang S, Ma C, Ren Z, Zhang Y, Hao K, Liu C, Xu L, He S, Zhang J

“…This study aimed to develop a novel diagnostic model based on miRNAs from glycosylated extracellular vesicles and evaluate its effectiveness in diagnosing gastric cancer.Methods: GlyExo-capture technology was used to isolate glycosylated extracellular vesicles from serum samples. …”
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Introducing a Coopetition Model for Domestic Airlines in Iran by Saedeh Ghayourisales, Mohsen Nazari, Mohammadali Shahhoseini

“…As a result of shifts in both internal and external landscapes, along with the swift advancements in technology encapsulated by the term VUCA (signifying volatility, uncertainty, complexity, and ambiguity), the conventional dichotomy of pure competition or complete cooperation has diminished in its efficacy. In its place, a novel mode of collaboration has emerged, characterized by a blend of cooperation to generate value and competition in the pursuit of value, termed "co-competitiveness." …”
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…For neonatal care, these resistance challenges increase the risk of treatment failures and mortality, underscoring the importance of enhanced infection prevention and novel therapeutic strategies.…”
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Longitudinal performance trajectories for youth female and male soccer players: 10m-sprint percentile curves adapted to biological age by Julia Hernandez, Chantal Widmer, Stephen Cobley, Dennis-Peter Born, Wolfgang Taube, Michael Romann

“…In addition to percentile curves based on chronological age, a novel approach incorporating biological age, which accounts for maturation variability during puberty, is introduced. …”
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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

“…In an effort to develop novel BoNT type A (BoNT/A) immunotherapeutics, sorted by flow cytometry plasmablasts and activated memory B cells from a donor repeatedly injected with BoNT/A for aesthetic botulinum therapy could be used due to obtain hybridomas producing native antibodies. …”
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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…<b>Background/Objectives</b>: Bempedoic acid (BA) is a novel cholesterol-lowering agent with proven positive effects on cardiovascular endpoints. …”
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Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…As a result, in the sample of the white population we examined, pathogenic variants previously described in other ethnic groups were revealed: E387K (rs55989760), R444* (rs377049098), R444Q (rs72549376), and P437L (rs56175199), as well as novel single-nucleotide deletion p.F114Lfs*38 in the CYP1B1 gene. …”
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Identification of the primary pollution sources and dominant influencing factors of soil heavy metals using a random forest model optimized by genetic algorithm coupled with geodet... by Tong Liu, Mingshi Wang, Mingya Wang, Qinqing Xiong, Luhao Jia, Wanqi Ma, Shaobo Sui, Wei Wu, Xiaoming Guo

“…This approach provides a novel perspective for HM source apportionment under complex environmental conditions.…”
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Consequences of insecticide overuse in Hungary: assessment of pyrethroid resistance in Culex pipiens and Aedes albopictus mosquitoes by Rebeka Csiba, Zsaklin Varga, Dorina Pásztor, Bianka Süle, Vera Ihuoma Ogoke Mxinwa, Zoltán Soltész, Brigitta Zana, Krisztián Bányai, Gábor Kemenesi, Kornélia Kurucz

“…Human activities such as international travel and trade, along with climate change, have facilitated the spread of invasive mosquitoes and novel pathogens across Europe, increasing the risk of mosquito-borne disease introduction and their spread. …”
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Effects of Electrical Stimulation on Activation of Mirror Neuron Network in Healthy Adults during Motor Execution and Imitation: An fNIRS Study by Yao Cui, Fang Cong, Fu-Biao Huang, Ming Zeng, Jun Wang

“…Conclusions: In this study, we present potential novel rehabilitation approaches that combines MNN strategies and low-frequency ES to enhance cortical activation. …”
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Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding

“…Distinctly, the findings of this meta-analysis suggest a novel therapeutic strategy for patients with chronic low back pain (LBP) and lumbar dysfunction by DDD.…”
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Assessing the effect of On-site supportive communication training (On-site SCT) on doctor burnout: a randomized controlled trial by K.K. Antonsen, J.D. Lyhne, A.T. Johnsen, S. Eßer-Naumann, L.Ø. Poulsen, L. Lund, S. Timm, L.H. Jensen

“…The aim of this study is to assess the effect of the novel On-site Supportive Communication Training (On-site SCT) in enhancing communication skills among oncologists and thereby addressing burnout. …”
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The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome by Ali Kemal Oguz, Cagdas Sahap Oygur, Bala Gur Dedeoglu, Irem Dogan Turacli, Sibel Serin Kilicoglu, Ihsan Ergun

“…If the platelets’ role is validated through further carefully designed research, the therapeutic potentials of selected conventional and/or novel antiplatelet agents remain to be evaluated in patients with IgG4-RD. …”
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Defibrillation pad placement accuracy among Advanced Life Support instructors: A manikin-based observational study examining experience, self-evaluation, and actual performance by Dennie Wulterkens, Freek Coumou, Cornelis Slagt, Reinier A. Waalewijn, Lars Mommers

“…Conclusion: This study corroborates and expands upon existing knowledge regarding the challenges of defibrillator pad placement, revealing substantial variation in placement accuracy among instructors. Our novel analysis of pad angles and anterior-posterior analysis demonstrates that a significant portion of pads are incorrectly placed. …”
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