Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally ac... by Dawna Salter, Himana Yalamanchi, Aiswarya Yalamanchi, Amulya Yalamanchi

“…This study suggests that SBS, a novel, standardized extract derived from the gum resin of B. serrata, improves recovery and reduces soreness following high-impact eccentric exercise.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/pubview2.php, Clinical Trial Registry of India (CTRI/2019/07/020323).…”
Get full text

Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort) by Gilles Wandeler, Samuel Bosomprah, Cleophas Chimbetete, Belinda Varaidzo Chihota, Guy Muula, Carolyn Bolton-Moore, Tinei Shamu, Ardele Mandiriri, Esau Banda

“…Additionally, we seek to pilot NCD interventions using novel methodologies like the trials within cohorts. …”
Get full text

Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach by Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeini, Seyed Amir Hossein Aqajari, Thomas D Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M Nelson, Amir M Rahmani

“…ConclusionsThis study presents a novel, multimodal machine learning framework for objective pain recognition in postoperative patients. …”
Get full text

Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy – protocol for the ERADICATE study: a phase II randomised controlled... by Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

“…Discussion The ERADICATE study will investigate exercise as a novel therapeutic approach for sensitising prostate cancer to EBRT by targeting a known mechanism of treatment resistance. …”
Get full text

Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design by Xiaoyi Li, Zechen Zhou, Yujia Ma, Kexin Ding, Han Xiao, Tao Wu, Dafang Chen, Yiqun Wu

“…<b>Conclusions</b>: <i>MRPS33</i>, <i>PIH1D2</i>, and <i>SD1HD</i> are associated with increased T2D risk through the environment influenced by paternal genotype, suggesting a novel perspective on paternal contributions to the T2D predisposition.…”
Get full text

Through each other's eyes: initial results and protocol for the co-design of an observational measure of adolescent-parent interaction using first-person perspective by Nicky Wright, Rebecca M. Pearson, Rebecca M. Pearson, Danielle Crook, Danielle Crook, Alice Bond, Tom Jewell, Tom Jewell

“…We hope to develop an observational measure using novel technological methods that can be used across a range of research and therapeutic settings.…”
Get full text

Collecting Real-World Data via an In-Home Smart Medication Dispenser: Longitudinal Observational Study of Survey Panel Persistency, Response Rates, and Psychometric Properties by Benjamin Ogorek, Thomas Rhoads, Erica Smith

“… Abstract BackgroundA smart medication dispenser called “spencer” is a novel generator of longitudinal survey data. The patients dispensing medication act as a survey panel and respond to questions about quality of life and patient-reported outcomes. …”
Get full text

Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Emerging evidence suggests a novel role for ferroptosis in the pathophysiology of ALI, though the precise mechanisms remain unclear. …”
Get full text

A pilot cluster randomized controlled trial assessing uptake of PrEP and contraception in hair salons in South Africa by Ingrid V. Bassett, Joyce Yan, Sabina Govere, Sthabile Shezi, Lungile M. Ngcobo, Shruti Sagar, Jana Jarolimova, Dani Zionts, Anele Khumalo, Zinhle Zwane, Christina Psaros, Nduduzo Dube, Robert A. Parker

“…Conclusions When offering a dynamic choice of integrated SRH services in urban hair salons in South Africa, we reached young women with risk factors for HIV, STIs, and unintended pregnancies. Hair salons are a novel venue for reaching young women who may not perceive themselves at risk for HIV, STIs, and unintended pregnancies. …”
Get full text

Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease by Zexuan Li, Yunhui Du, Lixin Jia, Jingyao Fan, Ruifeng Guo, Xinliang Ma, Xiao Wang, Shaoping Nie, Yongxiang Wei

“…C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. …”
Get full text

Multi-Class Guided GAN for Remote-Sensing Image Synthesis Based on Semantic Labels by Zhenye Niu, Yuxia Li, Yushu Gong, Bowei Zhang, Yuan He, Jinglin Zhang, Mengyu Tian, Lei He

“…To tackle these challenges, we propose the Multi-Class Guided GAN (MCGGAN), a novel network for generating remote-sensing images from semantic labels. …”
Get full text

Enhancing Soil Moisture Prediction in Drought-Prone Agricultural Regions Using Remote Sensing and Machine Learning Approaches by Xizhuoma Zha, Shaofeng Jia, Yan Han, Wenbin Zhu, Aifeng Lv

“…This study introduces a novel approach that, for the first time, employs a continuous time series of near-surface soil moisture as the upper boundary condition in the Richards equation to estimate high-resolution root-zone soil moisture in the North China Plain, thus enabling its large-scale application. …”
Get full text

Prevalence and characteristics of gastrointestinal disorders, medication use, and diagnostic interventions in pediatric patients with cystic fibrosis: a nested case–control analysi... by Carolena Trocchia, Carolena Trocchia, Maua Mosha, Bailey Hamner, Neil Goldenberg, Racha Khalaf

“…Prospective multicenter studies are warranted to substantiate these findings, further investigate risk factors for GI disorders, and to describe potential changes in GI disorders with novel CF disease-modifying therapies.…”
Get full text

Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study by Yannik Terhorst, Eva-Maria Messner, Kennedy Opoku Asare, Christian Montag, Christopher Kannen, Harald Baumeister

“… BackgroundUnobtrusively collected objective sensor data from everyday devices like smartphones provide a novel paradigm to infer mental health symptoms. This process, called smart sensing, allows a fine-grained assessment of various features (eg, time spent at home based on the GPS sensor). …”
Get full text

Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests by Aysha Mohamed Rafik Patel, Gina Gilpin, Anna Koniotes, Catherine Warren, Cian Xu, Paul W. Burgess, Dennis Chan

“…A subset of individuals also underwent testing on a novel battery of short digital tests assessing attention, speed of information processing and executive function, representing the domains primarily implicated in post-Covid cognitive dysfunction. …”
Get full text

StrideHD: A Binary Hyperdimensional Computing System Utilizing Window Striding for Image Classification by Dehua Liang, Jun Shiomi, Noriyuki Miura, Hiromitsu Awano

“…To alleviate this problem, we propose a novel HDC architecture, called StrideHD. By utilizing the window striding in image classification, StrideHD enables HDC system to be trained and tested using binary hypervectors and achieves high accuracy with fast training speed and significantly low hardware resources. …”
Get full text

A case-matched series comparing functional outcomes for robotic-assisted unicompartmental knee arthroplasty versus functionally aligned robotic-assisted total knee arthroplasty by Jonathan R. Manara, Macdaniel Nixon, Beth Tippett, Wil Pretty, Dermot Collopy, Gavin W. Clark

“…Functional alignment (FA) is a novel technique for performing a TKA and shares many principles with UKA. …”
Get full text

Exploring the Potential of Oxalyldihydrazide-Derived Schiff Bases as Versatile Ligands: Synthesis, Structural Characterization, and Magnetic Properties by Ernesto Costa-Villén, Marina Ortiz, Pedro Sitjar, Cristina Puigjaner, Mohamed Salah El Fallah

“…To further enrich this family and assess the potential impact of oxalyldihydrazide-derived Schiff bases in the realms of coordination chemistry and molecular magnetism, three novel ligands have been synthesized and investigated. i.e., N′1,N′2-bis((<i>E</i>)-pyridin-2-ylmethylene)oxalohydrazide (<b>H₂L1</b>), N′1-((<i>E</i>)-(3-methylpyridin-2-yl)methylene)-N′2-((<i>E</i>)-(6-methylpyridin-2-yl)methylene)oxalohydrazide (<b>H₂L2</b>) and N′1,N′2-bis((E)-phenyl(pyridin-2-yl)methylene)oxalohydrazide (<b>H₂L3</b>) were synthesized and then combined with various 3<i>d</i> metals, resulting in the formation of five new complexes with formula [Cu₅(L1)₂(H₂O)₈(MeOH)₂(NO₃)₂](NO₃)₄ (<b>1</b>), [Mn₂(HL2)₂(BzO)₂(MeOH)₂]·2MeOH (<b>2</b>), [Ni(HL2)₂]·2MeOH (<b>3</b>), [Ni₄(L2)₄]·4MeOH (<b>4</b>), [Ni₈(L3)₄(AcO)₄(H₂O)₁₂](OAc)₄ (<b>5</b>). …”
Get full text

Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…Copper (Cu) metabolism is strongly associated with liver disease. Cuproptosis is a novel format of cell death, and cuproptosis-related genes (CRGs) were identified. …”
Get full text

Major facility superfamily sugar transporter protein SsMFSST1 regulates Sporisorium scitamineum mating, pathogenicity, and sugar transport/absorption by Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen

“…In summary, this study identified a novel pathogenic gene in the S. scitamineum—the MFS sugar transporter gene, providing a molecular basis for understanding the pathogenic mechanism of the S. scitamineum. …”
Get full text