Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Here we investigated a transient surge in hepatic lipid droplets observed in newborn mice immediately after birth. We developed a novel model to quantify liver fat content without tissue processing. …”
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Gastric Peroral Endoscopic Myotomy (G-POEM) as a Treatment for Refractory Gastroparesis: Long-Term Outcomes by Jiaxin Xu, Tianyin Chen, Shaimaa Elkholy, Meidong Xu, Yunshi Zhong, Yiqun Zhang, Weifeng Chen, Wenzheng Qin, Mingyan Cai, Pinghong Zhou

“…Gastric peroral endoscopic myotomy (G-POEM) has been regarded as a novel and minimally invasive therapy for refractory gastroparesis. …”
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Investigating processes influencing simulation of local Arctic wintertime anthropogenic pollution in Fairbanks, Alaska, during ALPACA-2022 by N. Brett, N. Brett, K. S. Law, S. R. Arnold, J. G. Fochesatto, J.-C. Raut, T. Onishi, R. Gilliam, K. Fahey, D. Huff, G. Pouliot, B. Barret, E. Dieudonné, R. Pohorsky, J. Schmale, A. Baccarini, A. Baccarini, S. Bekki, G. Pappaccogli, F. Scoto, S. Decesari, A. Donateo, M. Cesler-Maloney, W. Simpson, P. Medina, B. D'Anna, B. Temime-Roussel, J. Savarino, S. Albertin, S. Albertin, J. Mao, B. Alexander, A. Moon, P. F. DeCarlo, V. Selimovic, R. Yokelson, E. S. Robinson

“…Both surface and elevated sources contribute to Fairbanks' regional pollution that is transported downwind, primarily to the south-west, and may contribute to wintertime Arctic haze. Inclusion of a novel power plant plume rise treatment that considers the presence of surface and elevated temperature inversion layers leads to improved agreement with observed CO and <span class="inline-formula">NO_<i>x</i></span> plumes, with discrepancies attributed to, for example, displacement of plumes by modelled winds. …”
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Cytotoxicity Potential of Endophytic Fungi Extracts from Terminalia catappa against Human Cervical Cancer Cells by Michèle Stella Majoumouo, Marius Belmondo Tincho, Rufin Marie Kouipou Toghueo, Thureyah Morris, Donavon Charles Hiss, Fabrice Fekam Boyom, Chitra Mandal

“…Endophytic fungi are potential sources of novel bioactive metabolites from a natural product drug discovery perspective. …”
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The Wayqecha Amazon Cloud Curtain Ecosystem Experiment: A new experimental method to manipulate fog water inputs in terrestrial systems by Daniel B. Metcalfe, Darcy F. Galiano Cabrera, Luis Miguel Alvarez Mayorga, Roxana Sacatuma Cruz, Daniela Corrales Alvarez, Blanca Rosa Espinoza Otazu, Walter Huaraca Huasco, Jimmy R. Chambi, Maria E. Ezquerra, Beisit L. Puma Vilca, Mark Mulligan, Matthew A. Vadeboncoeur, Heidi Asbjornsen, Paulo R. L. Bittencourt, Aline B. Horwath, David C. Bartholomew

“…Here, we present the design and performance of a novel experiment to actively manipulate low lying fog abundance in an old‐growth tropical montane cloud forest (TMCF) in Peru—the Wayqecha Amazon Cloud Curtain Ecosystem Experiment (WACCEE). …”
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Identification of standing dead trees in Robinia pseudoacacia plantations across China’s Loess Plateau using multiple deep learning models by Li Zhang, Xiaodong Gao, Shuyi Zhou, Zhibo Zhang, Tianjie Zhao, Yaohui Cai, Xining Zhao

“…These images were then integrated with a comprehensive evaluation of multiple detection algorithms, including Faster R-CNN, EfficientDet, YOLOv4, YOLOv5, YOLOv8, YOLOv9, and a novel model, YOLOv9-ECA. Particularly, the YOLOv9-ECA was developed by incorporating the ECA module into key network layers to enhance channel dependency modeling and improve feature representation for SDTs detection. …”
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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…The generation of TCR-like antibody and its CAR-T cells provides the state-of-the-art platform and proof-of-concept validation to broaden the scope of target antigen recognition and sheds light on the development of novel therapeutics for cancer immunotherapy.…”
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Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties by Raheel Suleman, Hira Choudhary, Muhammad Waseem, Jaza Maqbl Alshammari, Muhammad Muzamil, Huan Liu, Tariq Ismail, Muhammad Ammar Khan, Muhammad Qamar, Crossby Osei Tutu

“…Conclusively, owing to better potential of FP in improving the nutritional and microbial quality of mutton patties, the study further suggests its ability to act as a novel functional ingredient of choice in shelf-life extension of other food products.…”
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Combination of reverse shock index and simplified motor score as a strong discriminator of trauma outcomes by Meng-Yu Wu, Giou-Teng Yiang, Ding-Kuo Chien, Sy-Jou Chen, Chi-Ming Chu, Jui-Yuan Chung, Hon-Ping Ma, Mau-Roung Lin

“…Background The reverse shock index multiplied by simplified motor score (rSI-sMS) is a novel and rapid measure for assessing injury severity in patients with trauma in prehospital settings; however, its discriminant ability requires further validation.Methods A retrospective cohort study was conducted from trauma database of Taipei Tzu Chi Hospital to compare the accuracy of the rSI-sMS with that of the shock index, modified shock index, reverse shock index multiplied by the Glasgow Coma Scale (rSI-GCS), and the reverse shock index multiplied by GCS motor subscale (rSI-GCSM) for discriminating in-hospital mortality, intensive care unit (ICU) admissions, prolonged ICU stays ≥14 days, and prolonged hospital stays ≥30 days in patients with trauma.Results A total of 11,760 patients from the trauma database were included. rSI-sMS had significantly better accuracy in discriminating in-hospital mortality, ICU admissions, prolonged ICU stays (≥14 days), and prolonged hospital stays (≥30 days) than the shock index, modified shock index, and rSI-GCSM, whereas its accuracy was similar to that of the rSI-GCS. …”
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Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses by Chanasorn Poodendaen, Poonikha Namwongsakool, Sitthichai Iamsaard, Nareelak Tangsrisakda, Rarinthron Samrid, Chadaporn Chaimontri, Worrawit Boonthai, Suthat Duangchit

“…Conclusion: Multi-variable discriminant functions provide more reliability in sex determination while the combined-sex equations is the most effective method to estimate stature for contemporary Northeastern Thais. This novel method can be used to apply in the forensic anthropological analysis for Thai clavicle remain.…”
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The first application of flush probe arrays on HL-3 tokamak by Z.H. Huang, L.W. Yan, K.Y. Yi, Na Wu, W.J. Chen, W.C. Wang, Yu He, J. Chen, J. Cheng, W. Zhao, J.M. Gao, L. Nie, Z.B. Shi, X.Q. Ji, W.L. Zhong

“…It gradually increases with major radius. A novel design of ceramic isolation ring with a labyrinth can ensure reliable electrical insulation between the CFC tip and the divertor target plate where plasma dust and impurities are continuously deposited into their gaps due to long experimental operation. …”
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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…This discovery of the previously unknown crosstalk between the CWI and SIN pathways not only reshapes our understanding of fungal stress responses, but also unveils a promising new target pathway for the development of novel antifungal strategies.IMPORTANCEEchinocandin-resistant species pose a major challenge in clinical mycology by rendering one of only four lines of treatment, notably one of the two that are well-tolerated, ineffective in treating systemic mycoses of these species. …”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…Targeting NEAT1 might offer novel therapeutic strategies to rejuvenate aged BMSCs.…”
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Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa [version 2; peer review: 2 approved,... by Robert J Wilkinson, Francisco Lakay, Nicki Tiffin, Joel A Dave, Catherine Riou, Peter Raubenheimer, Anna K Coussens, Tsaone Tamuhla, Melissa J Blumenthal, Maleeka Abrahams

“…We implemented a genotyped population cohort with virtual follow up data in a resource-constrained African environment, demonstrating feasibility for scale up and novel health discoveries through nested case-control studies.…”
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Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…In the state of California’s Great Central Valley (United States), we developed a novel experimental framework to characterize five distinct “micro-patches” that capture the full spectrum of microclimate and vegetation zones modulated by the tracking PV system and O&amp;M. …”
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Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…Whether primary aldosteronism constitutes a novel risk factor for sudden death warrants further study. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Conclusion This study elucidates the complex cellular landscape and immune microenvironment of PCAS, highlighting potential molecular targets for the development of novel therapies. These findings underscore the importance of a multifaceted therapeutic approach for addressing the challenges posed by PCAS's heterogeneity and immune evasion. …”
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Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients by Sandra Crnko, Markella I. Printezi, Tijn P.J. Jansen, Laurynas Leiteris, Manon G. van derMeer, Hilde Schutte, Martijn vanFaassen, Bastiaan C. duPré, Nicolaas deJonge, Folkert W. Asselbergs, Carlo A.J.M. Gaillard, Hans Kemperman, Pieter A. Doevendans, Joost P.G. Sluijter, Linda W. vanLaake

“…The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease–biomarker interaction. …”
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Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development by Yalan Lu, Yanfeng Xu, Li Zhou, Siyuan Wang, Yunlin Han, Kewei Wang, Chuan Qin

“…The behavioral tests, including open-field test, novel object recognition test, and Morris water maze were performed, followed by β-amyloidosis plaque and neuron apoptosis analyses. …”
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Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study by Ping Zhou, Jun Chen, Ying Liu, Cheng Chen, Xin Guo, Zhangbin Yu, Jiebo Liu, Yanping Guo, Dan Dan Rao, Shengnan He, Xudong Yan, Wanxiang He, Songzhou Xu, Ruolin Zhang

“…A three-step analysis strategy—discovery, validation and clinical testing—will be used to identify and validate the clinical utility of novel biomarkers. Additionally, a nested case-control study will be conducted, matching participants 1:1 with a control group sharing similar BPD risk factors.Ethics and dissemination Our protocol has been approved by the Medical Ethics Committees of all participating hospitals, including Peking University Shenzhen Hospital, Shenzhen People’s Hospital, Shenzhen Baoan Women’s and Children’s Hospital, Longgang District Maternity and Child Healthcare Hospital, Nanshan Maternity and Child Healthcare Hospital and Shenzhen Luohu People’s Hospital. …”
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