Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study by Yongbing Sun, Xinbei Lin, Zhi Zou, Caiwen Zhao, Ao Liu, Jing Zhou, Zhonglin Li, Xiaoling Wu, Shewei Dou, Jiadong Zhu, Tao Li, Xue Lv, Yong Wang, Yongli Li

“…Abstract Background The Atherogenic Index of Plasma (AIP) is a novel biomarker for assessing the severity of atherosclerosis and has been shown to be closely associated with the risk of Type 2 Diabetes Mellitus (T2DM). …”
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Studies on the treatment of anaerobically digested sludge by white-rot fungi: evaluation of the effect of Phanerochaete chrysosporium and Trametes versicolor by Xuefeng Zhu, Shicai Cheng, Zexian Fang, Guangyin Zhen, Xueqin Lu, Hongbo Liu, Jing Qi, Zhen Zhou, Xuedong Zhang, Zhichao Wu

“…The present investigation explores the application of WRF in the treatment of anaerobically digested sludge, offering a novel approach for the valorization of sludge resources. …”
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Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study by Xiao-Qiang Han, Xiao-Qiang Han, Hui-Hui Jiang, Meng-Ling Chen, Meng-Ling Chen, De-Yang Han, De-Yang Han, Su-Fen Zhou, Su-Fen Zhou, Jin-Wen Wang, Shu-Shen Ji, Ling-Yun Wang, Jing-Wei Lou, Ming-Qun Li, Ming-Qun Li

“…Lastly, although the serum level of AEA was not significantly correlated with VitD or any of the top 6 marker genera, VitD was significantly negatively correlated with the relative abundance of Dorea, a novel finding in this context.DiscussionThe gut microbiota profile of the PE group was significantly different from that of the LP group. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…Conclusions The present results describe a novel association between GJD3 and FMD, providing evidence that FMD is related to changes in the inner ear channels, and supporting a new role of tectorial membrane proteins in MD.…”
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Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows by Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan, Jinku Yu, Jingru Zhang, Guo Han, Jiansheng Xiong, Hua Zhang, Xingyuan Cao, Haoshu Luo

“…In the current study, we developed a novel long-acting recombinant porcine FSH (rpFSH-pFc) consisting of porcine FSH and porcine fragment crystallizable (Fc) via (G4S)3 linker by using the available protein fusion technology to control the follicular development and maturation. …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…This review highlights the potential of biosensors as advanced analytical methods, including a section on prospects that address the challenges that could lead to significant advancements in environmental monitoring, highlighting the necessity of testing the new sensing developments under real conditions (composition/matrix of the samples), which are often overlooked, as well as the study of peptides as a novel recognition element in microplastic sensing.…”
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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. …”
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Exploring Disparities in Gill Physiological Responses to NaHCO₃-Induced Habitat Stress in Triploid and Diploid Crucian Carp (<i>Carassius auratus</i>): A Comprehensive I... by Shicheng Han, Lin Han, Fangying Yuan, Wenzhi Liu, Jing Wang, Xiaofeng Jin, Yanchun Sun

“…Overall, this study provides novel perspectives into species selection of crucian carp of different ploidy in saline–alkaline waters.…”
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Exploring SLEEPINESS through home monitoring with ultra-long-term subcutaneous EEG and ecological momentary assessment in sleepy treatment naïve obstructive sleep apnea patients st... by Mathias Sarkez-Knudsen, Martin Ballegaard, Martin Ballegaard, Henning Piilgaard, Esben Ahrens, Martin Christian Hemmsen, Tobias Søren Andersen, Jakob Eyvind Bradram, Preben Homøe, Preben Homøe

“…The following study protocol investigates the novel possibilities of ultra-long-term Electroencephalography (EEG) (ULT-EEG) home monitoring in sleepy OSA patients with a subcutaneous implant. …”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…These findings offer valuable insights into the intricate interplay between intratumoral bacteria and glioma, offering novel inspiration to the realm of glioma biology.…”
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Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

“…Conclusions: This study adds to existing evidence of associations between environmental exposures and dementia outcomes. Our findings provide novel evidence that differences in brain volume may mediate these relationships. …”
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Characteristics of the First Italian Older Adults Vaccinated with an Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine by Alexander Domnich, Andrea Orsi, Piero Luigi Lai, Elvira Massaro, Carlo-Simone Trombetta, Julieta Pastorino, Charlott Roihl, Marianna Pianta, Giancarlo Icardi, Donatella Panatto

“…<i>Conclusions</i>: The first Italian users of the novel RSVPreF3 OA vaccine were represented by high-risk individuals with a comparatively high prevalence of co-morbidities, high uptake of the seasonal respiratory vaccines and high trust in immunization.…”
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The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

“…The Rapid Eczema Trials project is a novel programme of research that aims to deliver multiple online RCTs, using a citizen science approach. …”
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Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors by Matthew P. Johnson, Ryan Keyho, Nicholas B. Blackburn, Sandra Laston, Satish Kumar, Juan Peralta, Suman S. Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero

“…We localized a significant (LOD score=3.18) and novel GSP QTL on chromosome 11q, which has been previously linked to type 2 diabetes. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Using a deep learning model, we found 107 (81%) of the putative causal genes (41 novel genes) were predicted to interact with SARS-COV-2 proteins. …”
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Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8 by Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic

“…Taken together, our data reveal a novel mechanism how human monocytes sense SARS-CoV-2 and suggest that targeting the cyclophilin-CD147 axis might be beneficial to alleviate overt myeloid-driven inflammation triggered by SARS-CoV-2 infection.…”
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High-Performance Hydrogen Sensing at Room Temperature via Nb-Doped Titanium Oxide Thin Films Fabricated by Micro-Arc Oxidation by Chilou Zhou, Zhiqiu Ye, Yue Tan, Zhenghua Wu, Xinyi Guo, Yinglin Bai, Xuying Xie, Zilong Wu, Ji’an Feng, Yao Xu, Bo Deng, Hao Wu

“…This study demonstrates the potential of MAO-fabricated Nb-doped TiO₂ thin films as efficient and reliable hydrogen sensors operating at room temperature, offering a pathway for novel gas-sensing technologies to support clean energy applications.…”
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Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies by Xiyun Rao, Ziyi Xin, Qingwen Yu, Lanlan Feng, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Jiake Tang, Xingwei Zhang, Mingwei Wang, Ling Liu

“…This study aims to summarize the correlation between the triglyceride-glucose-body mass index (TyG-BMI index), a novel surrogate indicator of insulin resistance, and the incidence of CVD in patients without CVD at baseline through meta-analysis. …”
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Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…The insights gained here lay the groundwork for developing diagnostic tools and novel therapeutic strategies for IPF.…”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Our results revealed that increasing innate immunity by G-CSF pretreatment and decreasing inflammatory responses using LBPK95A improved the survival rates in a rat sepsis model and could be a novel strategy to treat sepsis.…”
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