Use of virtual reality in port implantation to reduce perioperative anxiety and pain: protocol for a randomised controlled pilot trial at a single German university hospital (VIP-t... by Christoph W Michalski, Felix J Hüttner, Colette Dörr-Harim, Sandra Graf, Hannah Feldmann, Lisa S Hunold, Kira C Steinkraus, Nadir Nasir

“…If the intervention demonstrates that VR can effectively reduce perioperative anxiety and pain, it may become a novel standard of care to minimise the need for analgosedation or general anaesthesia in port implantation procedures and improve patient outcomes. …”
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Synergistic fermentation of vitamin B2 (riboflavin) bio-enriched soy milk: optimization and techno-functional characterization of next generation functional vegan foods by Ananya Rana, Neetu Kumra Taneja, Anupama Singh, Tejpal Dhewa, Vikram Kumar, Ankur Kumar, Komal Chauhan, Vijay Juneja, Harinder Singh Oberoi

“…This optimized fermentation process represents a novel approach to developing nutritionally enhanced dairy-free soy products with high riboflavin content, utilizing the synergistic benefits of co-fermentation by two riboflavin-producing L. plantarum strains and traditional starter culture of L. acidophilus. …”
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Adversarial measurements for convolutional neural network-based energy theft detection model in smart grid by Santosh Nirmal, Pramod Patil, Sagar Shinde

“…The attack comprises two methods: the first is we originally propose a novel Adversarial Data Generation Method (ADGM), which is an algorithm designed to generate adversarial data, and the other is Fast Gradient Sign Method (FGSM). …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…Collectively, these findings suggest that morin’s inactivation of the NLRP3 inflammasome pathway could offer a novel therapeutic strategy for counteracting pro-tumorigenic inflammation and metastatic progression in NSCLC.…”
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Genome-wide association study and genomic prediction of root system architecture traits in Sorghum (Sorghum bicolor (L.) Moench) at the seedling stage by Muluken Enyew, Mulatu Geleta, Kassahun Tesfaye, Amare Seyoum, Tileye Feyissa, Admas Alemu, Cecilia Hammenhag, Anders S. Carlsson

“…A total of 17 SNP loci significantly associated with the studied traits were identified, of which nine are novel loci. Among the traits, the highest number of significant marker-trait associations (MTAs) was identified for nodal root angle on chromosomes 1, 3, 6, and 7. …”
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Urinary concentrations of arsenic species in older Dutch adults and risk of chronic kidney disease by Hannah P. McKeon, Weiluan Chen, Jan Dirk te Biesebeek, Nanette G. Vrijenhoek, Jacqueline J.M. Castenmiller, Marcel J.B. Mengelers

“…A weak positive association was found between participants’ iAs EDIs and urinary TRA concentrations (ρ = 0.16–0.24).This study has generated novel concentration data of As species in morning urine samples of older Dutch adults. …”
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Processability and Material Behavior of NiTi Shape Memory Alloys Using Wire Laser-Directed Energy Deposition (WL-DED) by Hediyeh Dabbaghi, Nasrin Taheri Andani, Mohammad Pourshams, Mahyar Sojoodi, Behrang Poorganji, Mohammad Elahinia

“…This study presented a novel approach by thoroughly assessing the printability of Ni-rich Ni55.94Ti (Wt. %) SMA using the wire laser-directed energy deposition (WL-DED) technique, addressing the existing knowledge gap regarding the laser wire-feed metal additive manufacturing of NiTi alloys. …”
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Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

“…Furthermore, additional cellular experiments and animal model validations confirmed that the expression trends of EGR1 are highly consistent with our analytical findings.Conclusion: Our research has confirmed EGR1 as a key gene in MASLD, providing novel insights into the disease’s pathogenesis and identifying new therapeutic targets for its treatment.Keywords: metabolic dysfunction-associated steatotic liver disease, immune infiltration, machine learning, TF-miRNA-mRNA network, EGR1…”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Manipulating SHP2 expression or its target protein β-catenin may offer a novel approach to TNBC therapy.…”
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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…This collectively raises novel challenges due to higher age heavily impacting treatment. …”
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The Ethical Challenges of Gamification in Iran: Uncovering the Dark Side by Mona Jami Pour, Hamideh Binaei

“…This study identifies and prioritizes a set of ethical challenges of gamification to provide a holistic understanding of the darker aspects of implementing this novel approach within the cultural, social, and religious context of Iran. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Current therapeutic strategies are no longer able to meet the clinical needs; therefore, there is an urgent need to develop novel therapeutic strategies. This study aimed to evaluate the efficacy of phage therapy in treating bacterial infections.Methods: Isolated phage vB_Kpn_HF0522 and phage morphology were observed using transmission electron microscopy. …”
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Early selective attention to the articulating mouth as a potential female-specific marker of better language development in autism: a review by Itziar Lozano, Charlotte Viktorsson, Elena Capelli, Teodora Gliga, Valentina Riva, Przemysław Tomalski

“…Ultimately, we aim to target a novel protective candidate of language acquisition, informing tailored interventions that consider sex as an important source of individual variability.…”
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Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis by Li M, He J, Liang Y, Zou F, Gou C, Lv J, Zhang X, Li D, Yu Z

“…Lower risk of ISSNHL was found in relation to daytime dozing/sleeping (narcolepsy)-related SNPs.Conclusion: This phenomenon may provide a novel and meaningful therapeutic target for ISSNHL based on sleep medicine. …”
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Genome evolution following an ecological shift in nectar-dwelling Acinetobacter by Vivianna A. Sanchez, Tanya Renner, Lydia J. Baker, Tory A. Hendry

“…Here, we investigate the genomic adaptations required to successfully colonize a novel habitat like floral nectar. We performed comparative genomics analyses between nectar-dwelling Acinetobacter and Acinetobacter species from other environments, like soil and water. …”
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Biosynthesis of a range of ZnO nanoparticles utilising Salvia hispanica L. seed extract and evaluation of their bioactivity by Kiran Singh, Shweta Yadav

“…The study introduces a novel method for synthesizing Zinc oxide (ZnO) biometallic nanoparticles by employing aqueous extracts of Salvia hispanica L. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…We also discovered that CDK8/CDK19 affect splicing, a novel means by which Mediator kinases control gene expression. …”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds by Zhuo Deng, Jing Wang, Wentao Lyu, Xuwen Wieneke, Robert Matts, Xi Ma, Guolong Zhang

“…Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. …”
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Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Stu... by Haobin Peng, Jiajun Wen, Manli Chen, Zhengyuan Xia, Ying Jiang, Kaiqi Xie, Weitao Huang, Bangsheng Cui, Peixing Li, Yiwen Zhang, Xianping Wu

“…This single-center, randomized controlled, observer-blinded trial utilizes a novel combination of liposomal bupivacaine (LB) single-injection PENG block to examine its efficacy, duration, and safety in preoperative analgesia for hip fractures, aiming to develop a new preoperative analgesic protocol. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Conclusions: Our findings provide valuable insights into the molecular mechanisms driving the efficacy of TCM drugs against EBOV and suggest novel approaches for the development of anti-EBOV therapies.…”
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