Noninvasive Assessment of Liver Fibrosis by Magnetic Resonance Elastography in Patients with Rheumatic Disease on Long-Term Methotrexate Treatment by Arindam Nandy Roy, Anjani Kumar Darapureddy, Yarram Ashok Kumar

“…Magnetic resonance elastography (MRE) is a novel, reliable, and noninvasive imaging technique with excellent diagnostic accuracy for staging hepatic fibrosis and cirrhosis. …”
Get full text

Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

“…The NHE1/hERG1/β1/nNaV1.5 complex can be considered a novel biomarker and potential target for therapy for BCa patients.…”
Get full text

SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Conclusions Our data deciphered the mechanism of ETV1-mediated M2 macrophage infiltration in the TME of ESCC, which has important implications for the development of novel prognostic and therapeutic targets to optimize current therapies against ESCC.…”
Get full text

Understanding and reducing delayed dental care for early childhood caries: a structural equation model approach by Mengmeng Wang, Yu Zhang, Xiaofei Li, Xin Liu

“…Conclusion The present study developed a novel model to study the ECC treatment delay, elucidated the causal links between the identified variables, and proposed potential intervention strategies to enhance oral health awareness, knowledge, and skills among young children and their parents. …”
Get full text

Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives by Hafez Hend N., El-Gazzar Abdel-Rhman B. A.

“…3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. …”
Get full text

Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction by Vincent L. Biron, Ashlee Matkin, Morris Kostiuk, Jordana Williams, David W. Cote, Jeffrey Harris, Hadi Seikaly, Daniel A. O’Connell

“…Conclusions DdPCR offers a novel and ultrasensitive method of detecting RAS and BRAF mutations from thyroid FNABs. …”
Get full text

Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…These research findings offer a novel perspective on the potential therapeutic value of allicin as an adjunctive dietary supplement to conventional treatments for AMI. …”
Get full text

Collaboration-Based BIM Model Development Management System for General Contractors in Infrastructure Projects by Yu-Cheng Lin, Nan-Hai Lo, Hsin-Tzu Hu, Ya-Ting Hsu

“…Thus, this study proposes a novel approach and develops an information system to manage and track all CBMDM tasks for GCs during the BIM development process. …”
Get full text

Cross-sectional Study of EMG and EMG Rise During Fast and Slow Hamstring Exercises by Kasper Krommes, Markus Due Jakobsen, Thomas Bandholm, Lars Louis Andersen, Mette Zebis, Anthony Shield, Per Hölmich, Kristian Thorborg

“… # Purpose This cross-sectional study therefore aimed to compare the Nordic Hamstring curl with a conventional prone Leg Curl at different loads, and novel high velocity Hamstring Catches; in terms of peak normalized electromyographical activity (nEMG) and rate of electromyographic rise (RER) of Biceps Femoris long head, and angular velocity of the knee…”
Get full text

Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease by Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang

“…Thus, the miRNA-mRNA regulatory network was initially constructed and has the potential to provide novel insights into the pathogenesis and treatment of PD.…”
Get full text

Micro-Electro Nanofibrous Dressings Based on PVDF-AgNPs as Wound Healing Materials to Promote Healing in Active Areas by Liu T, Xie F, Geng L, He R, Sun M, Ni T, Xu P, Xing C, Peng Y, Chen K, Fang Y

“…By designing a micro-electro-Nanofiber dressing composed of piezoelectric polyvinylidene fluoride (PVDF) integrated with antimicrobial silver nanoparticles (AgNPs), this research aims to address the dual challenges of promoting effective wound healing and maintaining joint mobility.Methods: Herein, we developed a novel micro-electro-Nanofiber dressing using electrospinning technology, incorporating polyvinylidene fluoride (PVDF) with silver nanoparticles (AgNPs). …”
Get full text

COVID-19 Mortality in Children: A Referral Center Experience from Iran (Mofid Children’s Hospital, Tehran, Iran) by Shahnaz Armin, Seyed Alireza Fahimzad, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaiee, Noushin Marhamati, Seyyedeh Narjes Ahmadizadeh, Azita Behzad, Seyedeh Masumeh Hashemi, Saeed Sadr, Maryam Rajabnejad, Mahnaz Jamee, Abdollah Karimi

“…Background. The novel coronavirus disease 2019 (COVID-19) started in Wuhan, China, in December 2019. …”
Get full text

Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Contemporary research focal points primarily concentrate on the activation and inhibition pathways of the NLRP3 inflammasome, the exploration of novel HF targets, and the association between HF and mitochondrial function. …”
Get full text

COVID-19 Viral Pneumonia Complicated with Acute Pulmonary Embolism: A Descriptive Study by Hoda Salah Darwish, Mohamed Yasser Habash, Waleed Yasser Habash

“…To evaluate acute pulmonary embolism in patients with 2019 novel coronavirus (COVID-19) pneumonia using pulmonary CT angiography. …”
Get full text

Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products by Maihöfner C, Mallick-Searle T, Vollert J, Kalita P, Sood Sethi V

“…Although case reports and expert opinion should not be discounted, in the absence of other information they provide few actual data. Novel approaches using smartphone apps and artificial intelligence may provide new opportunities to collect RWE for nonprescription products, but these areas of research are in their infancy. …”
Get full text

Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy by Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

“…Pretreatment SIRI is a novel independent prognosticator that may further enhance the conventional tumor-node-metastases staging system in a more precise prediction of the OS and PFS outcomes of LAPC patients after radical CRT.…”
Get full text

Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…This research contributes to the development of novel, safe, and cost-effective agents for metastatic melanoma treatment and as a potential candidate for further cancer research.…”
Get full text

β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…While individual effects are supported preclinically, further studies investigating synergies, formulations, and clinical translation are needed to develop this promising novel therapeutic approach for improving fracture repair outcomes.Keywords: bone regeneration, fracture repair, osteoblast, osteogenesis, piezoelectric effect…”
Get full text

Spacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3–4 medial unicompartmental knee osteoarthri... by Yi Zhang, Xiangzhi Yin, Jinli Chen, Yingze Zhang, Tengbo Yu

“…Abstract Background Spacer-type tibial osteotomy have been proven a novel and effective osteotomy to treat osteoarthritis, while lack of comparison with other surgical methods in younger patients. …”
Get full text

Law of Ukraine “on administrative procedure”: new terminology and legal value of the law by Melnykovych M.

“…The result of this work is aimed at further encouraging an in-depth theoretical study of the field of administrative procedure as a “novel of Ukrainian legislation” and finding ways to effectively implement the Law of Ukraine “On Administrative Procedure” into the legal realities of our country today. …”
Get full text