Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation by Zhou C, Xiang T, Yu Y, Ma H, Liu C, Yang F, Yang L

“…This study introduces dose-weighted network pharmacology, a novel approach that incorporates drug dosage as a quantitative factor into network analysis to evaluate better and compare the therapeutic potential of TCM formulations.Methods: This study combines drug dosage with the PPI network to propose a theoretical algorithm for comparing the therapeutic efficacy of different traditional Chinese medicine formulations. …”
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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…IL-10 was detected in both eyes, suggesting a possible regulatory counterbalance.Discussion: This study offers novel insights into the pathophysiology of human adenoviral keratoconjunctivitis and its association with clinical data.Plain language summary: Despite the clinical significance of adenoviral keratoconjunctivitis, most studies have concentrated on defining its genotype. …”
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Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors by Saima Rashid, Abdul Bariq, Ilyas Ali, Sobia Sultana, Ayesha Siddiqa, Sayed K. Elagan

“…To further bolster the operator’s effectiveness, a number of tests of this novel kind of operator were conducted. We remark that in various time scale domains $$\mathbb {N}_{\ell }$$ , the investigated discrete formulations will be $$\rho ^{2}$$ -nonincreasing or $$\rho ^{2}$$ -nondecreasing by examining $$\rho$$ -monotonicity formulations and the basic properties of the suggested operator. …”
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Discrimination of Radiologists' Experience Level Using Eye-Tracking Technology and Machine Learning: Case Study by Stanford Martinez, Carolina Ramirez-Tamayo, Syed Hasib Akhter Faruqui, Kal Clark, Adel Alaeddini, Nicholas Czarnek, Aarushi Aggarwal, Sahra Emamzadeh, Jeffrey R Mock, Edward J Golob

“…ObjectiveThe objective of this study is to provide an alternative method for distinguishing between radiologists by means of captured eye-tracking data such that the raw gaze (or processed fixation data) can be used to discriminate users based on subconscious behavior in visual inspection. MethodsWe present a novel discretized feature encoding based on spatiotemporal binning of fixation data for efficient geometric alignment and temporal ordering of eye movement when reading chest x-rays. …”
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Development of the children's primitive reflex integration assessment scale by Meng Wang, Jing Yu, Hongyao Li, Chongran Zhao, Yichao Li, Xinyue Yang

“…Therefore, in the present study, we describe the development of a measurement scale for PR integration, a novel assessment tool to evaluate PR integration in children.MethodsCombining a literature review, practical experience, and results of specialized group discussions, a preliminary draft of the Children's Primitive Reflex Integration Measurement Scale (CPRIMS) was formulated. …”
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Correlation of irisin with lipid profile in type 2 diabetes mellitus by Wahengbam Diana Devi, Oinam Prabita Devi, Ursula Khwairakpam, Takhelmayum Paras Singh

“…Background: Irisin, a novel adipo-myokine, improves insulin sensitivity by browning of white adipose tissue and also promotes pancreatic β-cell proliferation. …”
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Carbon-carbon triple bond cleavage and reconstitution to achieve aryl amidation using nitrous acid esters by Zi-Ying Wang, Shoujun Wang, Nan-Nan Dai, Yao Xiao, Yu Zhou, Wen-Chan Tian, Dongru Sun, Qiang Li, Yong Wang, Wen-Ting Wei

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Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone... by Heather E. Owston, Payal Ganguly, Giuseppe Tronci, Stephen J. Russell, Peter V. Giannoudis, Elena A. Jones

“…Live cell tracking allowed determination of unique morphological and migration characteristics of periosteal MSCs that can be used for the development of novel bone graft substitutes to be preferentially repopulated by these cells.…”
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Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…From 1990 to 2021, while absolute ICH cases increased globally, age-standardized incidence rates declined. Our novel geographic analysis revealed East Asia bearing the highest burden, with Eastern Europe showing the highest age-standardized rates. …”
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The Architecture of BaTiO₃ Nanoparticles Synthesis via Temperature-Responsive for Improved Oil Recovery: A Molecular Dynamics Simulation and Core-Flooding Experimental S... by Surajudeen Sikiru, Hassan Soleimani, Amir Rostami, Leila Khodapanah

“…This shows that the wettability of the rock surface changed from oil-wet to water-wet with the novel application of BaTiO₃ nanoparticles. …”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Our study explored the novel role of cuproptosis-related genes (CRGs) in AS, focusing on immune cell infiltration and molecular clustering.Methods: By analyzing the peripheral blood gene expression datasets obtained from GSE73754, GSE25101, and GSE11886, we identified the expression patterns of cellular factors and immune infiltration cell related to cuproptosis. …”
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Identification of Five m6A-Related lncRNA Genes as Prognostic Markers for Endometrial Cancer Based on TCGA Database by Li Shan, Ye Lu, Cheng-Cheng Xiang, Xiaoli Zhu, Er-Dong Zuo, Xu Cheng

“…In this study, we explored the expression profiles of m6A-related lncRNAs of patients with UCEC and identified novel prognostic markers for UCEC. Methods. Gene expression and clinical data were extracted from The Cancer Genome Atlas. …”
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Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers by Ping Jin, Juan Ma, Peng Wu, Yitong Bian, Xueping Ma, Shaobin Jia, Qiangsun Zheng

“…These results highlight the complex interactions between lipid metabolism and inflammation in the pathophysiology of ACS, suggesting that targeting both Hcy and PCSK9 may offer novel therapeutic strategies to mitigate severe coronary lesions among high-risk patients.…”
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Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response by Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess

“…Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a novel small molecule inhibitor of GATA family proteins, has emerged as a promising tool for modulating GATA-3 activity. …”
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Cross-Sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Heated Tobacco Products in Japan: Wave 2 by Prasad Krishna, Shetty Mandara, Edward Lauren, Kanitscheider Claudia, Marczykowski Felix

“…Providing data on usage patterns is key to assessing the reduced-risk potential of novel tobacco and nicotine products as compared to conventional cigarettes at a population level. …”
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Maximal and Explosive Muscle Strength During Hip Adduction Squeeze and Hip Abduction Press Test Using A Handheld Dynamometer: An Intra- and Inter-tester Reliability Study by Lasse Ishøi, Kristian Thorborg, Laura Krohn, Lars Louis Andersen, Asger Møller Nielsen, MIkkel Bek Clausen

“…An alternative to unilateral testing, is the long-lever hip adduction squeeze test and a novel bilateral hip abduction press test. While promising intra-tester reliability has been found for maximal strength during the long-lever hip adduction squeeze test, inter-tester reliability may be more challenging during both maximal and explosive strength measurements…”
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To Develop Biomarkers for Diabetic Nephropathy Based on Genes Related to Fibrosis and Propionate Metabolism and Their Functional Validation by Sha Li, Jingshan Chen, Wenjing Zhou, Yonglan Liu, Di Zhang, Qian Yang, Yuerong Feng, Chunli Cha, Li Li, Guoyong He, Jun Li

“…Via bioinformatic analyses, the risk of fibrosis and propionate metabolism-related biomarkers in DN were explored, thereby providing novel ideas for research related to DN diagnosis and treatment.…”
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Response mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation by Xue-Xue Ji, Quan Zhang, Bai-Xue Yang, Qing-Ran Song, Zhao-Yong Sun, Cai-Yun Xie, Yue-Qin Tang

“…The findings suggest that the longevity-regulating pathway may play a critical role in adapting to varying ethanol stress by regulating mitochondrial respiration, glycerol synthesis, ergosterol synthesis, antioxidant enzyme, and HSPs. This work provides a novel and valuable understanding of the mechanisms that govern ethanol tolerance during continuous fermentation.…”
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C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression by Zhenbing Lu, Ling Zhu, Changlin Yi, Bi Su, Renying Wang

“…Additionally, GSK484 intervention on Th1 cell phenotype further affected lung epithelial cell injury.Conclusion In summary, we revealed the mechanism of C5a/C5aR-induced PAD4 upregulation via neutrophil activation in sepsis-associated lung injury, causing a Th1/Th2 imbalance and lung injury, providing a novel approach for sepsis-associated lung injuries treatment.…”
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Zenith Tropospheric Delay Forecasting in the European Region Using the Informer–Long Short-Term Memory Networks Hybrid Prediction Model by Zhengdao Yuan, Xu Lin, Yashi Xu, Jie Zhao, Nage Du, Xiaolong Cai, Mengkui Li

“…This study introduced a novel methodology for high-precision ZTD modeling, which is significant for improving accurate GNSS positioning and detecting water vapor content.…”
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