Identification of Parkinson’s disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach by Yifeng Yang, Liangyun Hu, Yang Chen, Weidong Gu, Guangwu Lin, YuanZhong Xie, Shengdong Nie

“…ObjectiveThis study aim to leverage advanced machine learning techniques to develop and validate novel MRI imaging features and single nucleotide polymorphism (SNP) gene data fusion methodologies to enhance the early identification and diagnosis of Parkinson’s disease (PD).MethodsWe leveraged a comprehensive dataset from the Parkinson’s Progression Markers Initiative (PPMI), which includes high-resolution neuroimaging data, genetic single-nucleotide polymorphism (SNP) profiles, and detailed clinical information from individuals with early-stage PD and healthy controls. …”
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Soluble Markers of Antibody Secreting Cell Function as Predictors of Infection Risk in Rheumatoid Arthritis by Maria J. Gutierrez, Stephen V. Desiderio, Nae-Yuh Wang, Erika Darrah, Laura Cappelli, Gustavo Nino, Michelle Jones, Clifton O. Bingham

“…Further delineating the link between ASC and infection susceptibility in RA may optimize disease management and provide novel insights into disease pathogenesis that are susceptible to intervention.…”
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Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites by Khalid A. Khan, Gadeer R. Ashour, Mahmoud A. Hussein

“…This study reports the successful synthesis of a novel polyketoamine (PKA) and its nanocomposites, including graphene nanosheets (GNS) and multi-wall carbon nanotubes (MWCNT), through an in-situ polycondensation reaction incorporating sulfur and thiazole moieties. …”
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Seroprevalence of Hepatitis C Viral Infection in Ethiopia: A Systematic Review and Meta-Analysis by Teshiwal Deress, Yihenew Million, Teshome Belachew, Mohabaw Jemal, Mekonnen Girma

“…Strengthening the scope of existing prevention and control programs and implementing novel approaches, including screen-and-treat, could significantly help to tackle this critical public health issue. …”
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A radiomics and deep learning nomogram developed and validated for predicting no-collapse survival in patients with osteonecrosis after multiple drilling by Fan Liu, De-bao Zhang, Shi-huan Cheng, Gui-shan Gu

“…Conclusion This study introduces a novel approach that integrates radiomics and deep learning techniques and demonstrates superior predictive performance for no-collapse survival after multiple drilling. …”
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Antistripping potential of cement kiln dust on recycled asphalt pavement. Innovative Infrastructure Solutions by Usman, Kabiru Rogo, Ali, Atheer Muhammed, Wakawa, Yakubu Mamman, Usman, Abbas

“…This study investigates the potential use of CKD as a fller material and its novel antistripping properties on recycled asphalt pavement (RAP). …”
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Systematic Review and Meta-Analysis on Human African Trypanocide Resistance by Keneth Iceland, Kasozi, Ewan Thomas, MacLeod, Susan Christina, Welburn

“…T. brucei strains were largely resistant to diamidines and the use of high trypanocide concentrations in clinical studies have proved fatal in humans. Studies to develop novel chemotherapeutical agents and identify alternative protein targets could help to reduce the emergence and spread of HATr.…”
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An Update on African Trypanocide Pharmaceutics and Resistance. by Keneth Iceland, Kasozi, MacLeod, Ewan Thomas, Ntulume, Ibrahim, Welburn, Susan Christina

“…Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT. …”
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ORCHAMP: an observation network for monitoring biodiversity and ecosystem functioning across space and time in mountainous regions by Thuiller, Wilfried, Saillard, Amélie, Abdulhak, Sylvain, Augé, Vincent,  Birck, Carole, Bonet, Richard, Choler, Philippe, Delestrade, Anne,  Kunstler, Georges, Leccia, Marie-France, Lienard, Bertrand, Poulenard, Jérome, Valay, Jean-Gabriel, Bayle, Arthur, Bonfanti, Nicolas, Brousset, Lenka,  Bizard, Léa,  Calderón-Sanou, Irene, Dentant, Cédric, Desjonquères, Camille, Gielly, Ludovic, Guéguen, Maya, Guiter, Frédéric, Hedde, Mickael,  Hustache, Eric, Kedhim, Norine, Lapenu, Pierre, Le Guillarme, Nicolas,  Marchal, Lise, Mahieu, Chloé, Martin, Gabrielle, Martinez-Almoyna, Camille,  Miele, Vincent, Murienne, Jérôme, Paillet, Yoan, Rome, Maxime,  Renaud, Julien, The Orchamp Consortium

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Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme by Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

“…Conclusions This study demonstrates the power of combining machine learning and Mendelian Randomization to uncover novel genetic markers for GBM. The identified genes offer promising potential as biomarkers for GBM diagnosis and therapy, providing new avenues for personalized treatment strategies.…”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…These results suggest that the combination of scDb-hERG1-β1 and statins represent a potential novel strategy for treating PDAC patients.…”
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Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

“…Genomically-matched treatment was determined based on the novel information obtained from NGS testing, while results from conventional molecular tests were excluded. …”
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Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1 by Xinxin Li, Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, Wen Zhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan, Huina Zhang

“…Conclusion This study reveals a novel role of K.pn EVs in endothelial dysfunction and dissects the relevant mechanism involved in this process, which will help to establish a comprehensive understanding of K.pn EVs in endothelial dysfunction and hypertension from a new scope.…”
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Biologically targeted discovery-replication scan identifies G×G interaction in relation to risk of Barrett’s esophagus and esophageal adenocarcinoma by Li Yan, Qianchuan He, Shiv P. Verma, Xu Zhang, Ann-Sophie Giel, Carlo Maj, Kathryn Graz, Elnaz Naderi, Jianhong Chen, Mourad Wagdy Ali, Puya Gharahkhani, Xiang Shu, Kenneth Offit, Pari M. Shah, Hans Gerdes, Daniela Molena, Amitabh Srivastava, Stuart MacGregor, Claire Palles, René Thieme, Michael Vieth, Ines Gockel, Thomas L. Vaughan, Johannes Schumacher, Matthew F. Buas

“…The first systematic G×G investigation in BE/EAC, this study uncovers differential risk associations for CDKN2B variation by BLK genotype, suggesting novel biological dependency between two risk loci encoding key mediators of tumor suppression and inflammation.…”
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Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes by Xiaojing Wang, Tong Wang, Qian Zhang, Li Xu, Xinhua Xiao

“…These findings suggest that insulin may be a potentially novel and inexpensive intervention for prediabetes.…”
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Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study by Suming Dai, Ping Wang, Sijia Wang, Sijia Wang, Hong Chen, Zhixin Cui, Wenhai Lu, Wenhai Lu, Ziyi Zhou, Ziyi Zhou, Nan Zhang, Zhuo Wang, Tengfei Lin, Tengfei Lin, Yun Song, Yun Song, Lishun Liu, Lishun Liu, Xiao Huang, Ping Chen, Genfu Tang, Yong Duan, Yong Duan, Hao Zhang, Binyan Wang, Binyan Wang, Binyan Wang, Yan Yang, Yan Yang, Yan Yang, Zezhong Tian

“…In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.DiscussionAlthough no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma α-tocopherol levels may offset the potential protective effect of plasma VD3 on blood pressure among hypertensive adults. This provided a novel perspective for exploring the joint effects of fat-soluble vitamins on blood pressure. …”
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Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers by Fang Cai, Meiping Huang, Wei Liu, Xiaoling Wan, Kai Qiu, Xiao Xu

“…Despite their promising effects in other animal species, the impact of this novel compound organic acidifier on broiler performance, metabolism, and immune response has not been fully elucidated. …”
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Impacts of the “Coal to Gas” Policy on Rural Air VOC Level and Ozone Potentials in North China by Zhiyong Li, Chen Liu, Chengjing Cao, Zhen Zhai, Changtao Huang, Zhuangzhuang Ren, Jixiang Liu, Lan Chen, Songtao Guo, Dingyuan Yang

“…The study was expected to provide some novel strategies for further VOC control and air quality improvement in rural area.…”
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Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…Identifying the host factors, exploring their role in HCV RNA replication, and studying viral effects on their expression is essential for understanding the mechanisms of viral replication and developing novel, effective curative approaches. It is known that the host factors PREB (prolactin regulatory element binding) and PLA2G4C (cytosolic phospholipase A2 gamma) are important for the functioning of the viral replicase complex and the formation of the platforms of HCV genome replication. …”
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Characteristics of climate resource utilization and economic benefits in new planting pattern for fresh faba bean and fresh maize in Yangtze River Delta by Bo Li, Qingming Ren, Xiaoxu Shi, Wenyuan Shen, Yafeng Wei, Fei Xiong

“…In this research, we aimed to construct a novel planting pattern for faba bean and maize with high-efficiency utilization of climate resources for application in production. …”
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