Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…Notably, the use of the JNK inhibitor SP600125, the PI3K inhibitor LY294002, and the ERK1/2 inhibitor U0126 antagonized the protective effects of DHEA, with SP600125 showing the most significant impact on both HVSMCs and HUVECs.ConclusionOur study has identified a novel mechanism underlying the cardioprotective effects of DHEA. …”
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Exploration and characterization of lipid-degrading bacteria from palm oil mill effluent by P. Periadnadi, N. Nurmiati, F.W. Siregar, T.W. Edelwis

“…BACKGROUND AND OBJECTIVES: Lipid-degrading bacteria found in processing ponds of palm oil mill effluent are recognized for the capacity to break down lipid using lipase enzyme. Identifying novel strains of these bacteria with high bioremediation potential contributes valuable insights to the sustainable management of palm oil mill effluent. …”
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Yield, Quality, Antioxidants, and Mineral Composition of Traditional Italian Storage Onion Cultivars in Response to Protein Hydrolysate and Microalgae Biostimulation by Alessio Vincenzo Tallarita, Otilia Cristina Murariu, Tomas Kopta, Florin Daniel Lipșa, Leonardo Gomez, Eugenio Cozzolino, Pasquale Lombardi, Silvio Russo, Gianluca Caruso

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Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…Conclusions: The research conducted in an “e-Zawody” project concludes that the integration of VR and virtual avatars significantly enhances public speaking training, offering a novel, effective and engaging approach. The development of the algorithm marks a pivotal advancement in educational technology, providing a platform that surpasses traditional training methods. …”
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Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II by Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris

“…While a number of drugs with competitive inhibitory action and covalent binding capacity are available, undesired side effects exist partly attributed to drug kinetics, and research for finding novel, potent, and safer compounds continues. Despite the research, a low number of uncompetitive and non-competitive inhibitors, which could be of worth for pharmaceutical and mechanism studies, was mentioned. …”
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Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…The launch of open-access DDE datasets has the potential to stimulate further research and novel discoveries in this field.…”
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Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…Cannabinoids offer a novel pharmacotherapeutic approach and can complement other medications to address unmet clinical needs in numerous patients, which has led to a global increase in the use of these products. …”
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Genotype-phenotype correlations for 17 Chinese families with inherited retinal dystrophies due to homozygous variants by Xue Fan, Zhen Li, Lingzhi Sha, Xunlun Sheng, Weining Rong

“…According to 12 patients (70.6% ), they had the best corrected visual acuity (monocular) < 0.3. 3 were blind, 9 with moderate to severe visual impairment, and 2 with mild visual impairment. 16 homozygous variants were detected in 9 different genes, of which 7 were novel homozygous variants, including frameshift variants, missense variants, and a copy number variant. …”
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The prognostic importance of the pan-immune-inflammation value in patients with septic shock by Yasemin Bozkurt Turan

“…Abstract Introduction The purpose of this study was to determine whether the pan-immune-inflammation value (PIV), a novel biomarker combining neutrophil platelet, monocyte, and lymphocyte counts, some of the most widespread indicators of systemic inflammation, can predict mortality and prognosis in patients admitted to the intensive care unit (ICU) with septic shock. …”
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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…Guanxinning tablet (GXNT) is a novel Chinese medicine formula, which has been clinically used to treat coronary heart disease for many years. …”
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Progress in research on strain glass transition in Ni-Ti based alloys by ZHAO Xinqing, WANG Kai, LYU Chao, ZHANG Kaichao, HOU Huilong

“…In the present paper，the proposition, novel properties and the research progress of the strain glass transition in Ni-Ti based alloys were reviewed. …”
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High-Coercivity Ferrimagnet Co₂FeO₂BO₃: XMCD Insights into Charge-Ordering and Cation Distribution by Mikhail S. Platunov

“…This XMCD study opens the door to the production of novel high-coercivity, lanthanide-free magnetic materials by showing that targeted substitution at specific crystallographic sites can significantly enhance the magnetic properties of such materials.…”
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Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways by Fuxia Hu, Chao Liu, Fengqin Wang, Changxin Zhou, Maotong Zhu, Dongxiao Sun-Waterhouse, Zhaosheng Wang

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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…These findings offer valuable insights that could inform early detection strategies and the development of novel therapeutic approaches. Further exploration and validation of PAQR11 are essential, highlighting the need for its integration into future oncological research and treatment strategy development. …”
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IUENNA – openIng the soUthErn jauNtal as a micro-regioN for future Archaeology: A «para-description» by Hagmann, Dominik, Reiner, Franziska

“…IUENNA is a collaborative effort in digital archaeology and digital humanities: It involves a diverse set of stakeholders, including the State Museum for Carinthia (kärnten.museum), the Austrian Archaeological Institute (ÖAI) at the Austrian Academy of Sciences (ÖAW), the Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH) at the ÖAW, the Austrian Federal Monuments Authority (BDA), and the archaeological service company ARDIG. The project marks a novel initiative in Austrian Classical studies by providing a robust model for the active and sustainable long-term archiving of digital archaeological data. …”
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Mapping provider and consumer voices using the AACTT framework: a focus group study of advance care planning by Lisa Guccione, Stephanie Best, Sonia Fullerton, Sanchia Aranda, Jill J. Francis

“…Misalignment was found predominantly in actions ‘occurring sometimes’, with no converging perspectives reported for the context and time domains. Conclusion This novel application of the AACTT framework systematically brings in the consumer voice in ways that may influence the delivery of care. …”
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Stemness-related gene signatures as a predictive tool for breast cancer radiosensitivity by Jinzhi Lai, Rongfu Huang, Jingshan Huang

“…This signature may guide personalized treatment strategies and inform the development of novel radiosensitizing agents.…”
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Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…<h4>Conclusions</h4>Vaccination of mice with rTsCTL elicited an obvious protective immunity against larval challenge, impeded larval invasion of gut mucosa, enhanced gut epithelial integrity and barrier function, reduced worm burdens; it also alleviated gut and muscle inflammation. TsCTL might be a novel candidate target molecule for anti-Trichinella vaccines.…”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…It is expected that these data will provide novel insights into the mechanisms and potential targets underlying muscle wasting in stroke.…”
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Biomechanical simulation of bed turning post-acetabular fracture fixation by Haiyang Wu, Zaijie Sun, Qixiao Shen, Xuejian Wu, Cheng Li, Xianhua Cai

“…This study aims to introduce a novel loading protocol designed to preliminarily simulate the action of turning over in bed and to compare the biomechanical properties of two fixation methods for acetabular fractures under this new protocol. …”
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