Efficacy and Safety of HAPC in Barrett's Esophagus – A Multicenter Italian Prospective Study by Davide Massimi, Roberta Maselli, Silvia Pecere, Cristiano Spada, Gianluca Andrisani, Francesco Maria Di Matteo, Antonella La Terra, Franco Coppola, Antonio Capogreco, Roberto De Sire, Ludovico Alfarone, Maddalena Menini, Marco Spadaccini, Cesare Hassan, Alessandro Repici

“…Hybrid argon plasma coagulation (H-APC) is a novel technique for the ablation of neoplastic Barrett Esophagus (BE), consisting in submucosal fluid injection and subsequent APC of visible BE. …”
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MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

“…In this study, we characterized a novel C-type lectin, MsCL-P1, from the largemouth bass (Micropterus salmoides), an economically important fish species in aquaculture. …”
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De Novo Mutation of m.3243A>G together with m.16093T>C Associated with Atypical Clinical Features in a Pedigree with MIDD Syndrome by Zhixin Jiang, Yinan Zhang, Jingbin Yan, Fengwen Li, Xinqian Geng, Huijuan Lu, Xiaoer Wei, Yanmei Feng, Congrong Wang, Weiping Jia

“…In our study, we aimed to investigate the heredity way of the m.3243A>G among pedigrees with MIDD and discover novel mitochondrial DNA mutations related to atypical clinical phenotypes. …”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications.…”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).…”
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Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers by Zhihao Lu, Mingfei Geng, Yongtao Han, Jianzhong Cao, Jun Wang, Tianshu Liu, Xianglin Yuan, Xue Meng, Yanqiao Zhang, Rong Zhao, Lixin Wan, Enxiao Li, Wenran Wang, Zhijie Li, Danfeng Shi, Jing Qian, Si Shi, Fengshi Dong, Lin Shen

“…These findings highlight the need for novel EC treatments before immunotherapy was introduced, and provide a baseline for evaluating the benefits of immunotherapy, now that this treatment is widely used in this setting.…”
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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression by Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

“…VARS1 promotes aggressiveness through the modulation of MAGI1, representing a novel targetable vulnerability in HCC.…”
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A randomized comparative effectiveness trial to evaluate two programs for promotion of physical activity after spinal cord injury in manual wheelchair users by Jenna M. Martinez, Jenna M. Martinez, Lisa L. Haubert, Valerie J. Eberly, Walter B. Weiss, Jeffery W. Rankin

“…ObjectiveThe goal of this study was to determine the effectiveness of a novel whole of day activity accumulation (WODAA) physical exercise program. …”
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Association between SPISE and NAFLD in patients with type 2 diabetes by Hongyan Zhao, Hongyan Zhao, Baolan Ji, Xin Wang, Shuwei Shi, Shuwei Shi, Jie Sheng, Jie Sheng, Xuan Ma, Xuan Ma, Bo Ban, Guanqi Gao

“…The single point insulin sensitivity estimator (SPISE) is a novel index. This study aims to explore the association between SPISE and NAFLD in T2D population.MethodsThis study included a total of 2,459 patients with T2D. …”
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Adsorption of Anionic Surfactants onto Alumina: Characteristics, Mechanisms, and Application for Heavy Metal Removal by Thi Minh Thu Nguyen, Thi Phuong Thao Do, Thi Sim Hoang, Ngoc Viet Nguyen, Huy Dong Pham, Trung Dung Nguyen, Thi Ngoc Mai Pham, Thanh Son Le, Tien Duc Pham

“…We demonstrate that SMA is a novel adsorbent for removal of Cd2+ from aqueous solution.…”
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Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor by Toru Momozane, Eriko Fukui, Soichiro Funaki, Makoto Fujii, Yuhei Kinehara, Emiko Ito, Shigeru Miyagawa, Yuko Ohno, Yoshiki Sawa, Meinoshin Okumura, Yasushi Shintani

“…In the present paper, we propose a novel method for elimination of residual undifferentiated murine iPSCs using JQ1, a potent inhibitor of bromodomain (BRD) and extraterminal domain (BET) family proteins, for efficient differentiation into ATII. …”
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Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice by Xiaohang Wang, Xiaohang Wang, Xiaohang Wang, Qianqian Wang, Zhensheng Cai, Chengming Ni, Huan Wang, Hui Liu, Yusong Zhao, Jinbang Wang, Subo Liu, Xueying Wang

“…We showed that the fluorescence intensities of IL-1β, IL-6, TNF-α, and TGF-β1 in hippocampus were decreased after the Pdpn knocking down in astrocytes of T2DM mice.ConclusionIn summary, this study demonstrates that Pdpn exerts a novel player in T2DM-induced neuroinflammation and cognitive decline. …”
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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

“…Study eligibility criteria includes (1) individuals with a Fontan circulation aged ≥6 years, at least 12 months post-Fontan procedure and enrolled in the ANZFR; (2) parents of individuals enrolled in the ANZFR; and (3) siblings aged ≥6 years of an individual enrolled in the ANZFR. A novel, online research platform is used to distribute personalised assessments tailored to participant age and developmental stage. …”
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Community credit scores and community socioeconomic deprivation in association with type 2 diabetes across an urban to rural spectrum in Pennsylvania: a case–control study by Jonathan Pollak, Melissa N Poulsen, Karen Bandeen-Roche, Katherine Moon, Joseph DeWalle, Annemarie G Hirsch, Brian S Schwartz, Lorraine Dean, Meghann Reeder

“…Stratified models assessing independent effects of CCS and CSD showed mainly consistent associations, indicating each community-level measure was independently associated with T2D.Conclusion CCS may capture novel, health-salient aspects of community socioeconomic conditions, though questions remain regarding the mechanisms by which it influences T2D and how these differ from CSD.…”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…These findings highlight the novel potential of Co3O4NPs as potent inducers of melanoma A-375 cell death in a concentration-dependent manner through excessive ROS production, genomic instability, mitochondrial dysfunction and dysregulation of apoptotic and mitochondrial gene expression, ultimately promoting apoptosis in A-375 cells. …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Abstract Background For resectable adenocarcinoma of the esophagogastric junction (AEG), current treatment exploration primarily focuses on perioperative chemotherapy regimens combined with PD-1/PD-L1 inhibitors, but the long-term survival benefits of still require further investigation, and the use of upfront immunotherapy is typically restricted to patients with metastatic MSI-H (M1 MSI-H) disease due to their potential responsiveness to immunological agents. Adebrelimab, as a novel PD-L1 antibody, has not yet been proven for its efficacy and safety in adenocarcinoma of the esophagogastric junction. …”
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Correlations of gene expression, codon usage bias, and evolutionary rates of the mitochondrial genome show tissue differentiation in Ophioglossum vulgatum by Jing Hao, Yingyi Liang, Ting Wang, Yingjuan Su

“…Moreover, we also provide novel insights into understanding the effects of plant mitochondrial gene expression on evolutionary patterns.…”
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Validation of a tele-robotic ultrasound system for abdomen and thyroid gland explorations: a comparison with standard ultrasound by Andreu Antolin, Nuria Roson, Marina Planes, Mar Castillo, Anna Alberti, Manuel Escobar

“…Abstract Background Tele-robotic ultrasound (US) is a novel technique that might help overcome the current shortage of radiologists and poor access to radiologists and/or sonographers in remote or rural areas. …”
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Detection of Masses in Mammogram Images Based on the Enhanced RetinaNet Network With INbreast Dataset by Wang M, Liu R, Luttrell IV J, Zhang C, Xie J

“…Specifically, we introduced a novel modification to the network structure, where the feature map M5 is processed by the ReLU function prior to the original convolution kernel. …”
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A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma by Zeng-Hong Wu, Yun Tang, Yue Zhou

“…Taken together, our study unearths a novel metabolic gene signature for the prediction of HNSCC prognosis based on the TCGA dataset. …”
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