PolyRes-Net: A Polyhierarchical Residual Network for Decoding Anatomical Complexity in Medical Image Segmentation by Amr Magdy, Khalid N. Ismail, Marghny H. Mohamed, Mahmoud Hassaballah, Haitham Mahmoud, Mohammed M. Abdelsamea

“…In this paper, we introduce a novel architectural framework, which we refer to as the Polyhierarchical Residual Network (PolyRes-Net). …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

“…X-ray quasiperiodic eruptions (QPEs) are a novel mode of variability in nearby galactic nuclei whose origin remains unknown. …”
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Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol by Shehzadi Naureen, Hussain Khalid, Islam Muhammad, Bukhari Nadeem Irfan, Khan Muhammad Tanveer, Salman Muhammad, Siddiqui Sabahat Zahra, Rehman Aziz-Ur, Abbasi Muhammad Athar

“…The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. …”
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Effectiveness of the ARTHE-e app for exercise adherence in people with knee osteoarthritis: protocol for a randomised controlled trial by Bruno Pereira, Charlotte Lanhers, Emmanuel Coudeyre, Lech Dobija, Mathilde Pelletier-Visa, Alexis Bonhomme

“…In response, we have developed a novel smartphone-based m-health application, ARTH-e, specifically designed to enhance adherence to adapted physical activity in individuals with knee osteoarthritis. …”
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Sustainable foam glass property prediction using machine learning: A comprehensive comparison of predictive methods and techniques by Mohamed Abdellatief, Leong Sing Wong, Norashidah Md Din, Ali Najah Ahmed, Abba Musa Hassan, Zainah Ibrahim, G. Murali, Kim Hung Mo, Ahmed El-Shafie

“…In this context, the current study proposes a novel approach by developing a thoughtful system for assessing performance and intelligent design utilizing ML models such as Gradient Boosting (GB), Random Forest (RF), Gaussian Process Regression (GPR), and Linear Regression (LR) to predict porosity and compressive strength (CS) of FG. …”
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Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis by Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan

“…Collectively, these findings reveal a novel role of basophil autophagy in SLE, highlighting its potential as a therapeutic target.…”
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Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…Conclusion This study reveals a novel IR-mediated Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes and propose Rela as a potential drug target for mitigating IR-induced spermatogenesis disorders. …”
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Identification of a pathogenic founder variant in the WFS1 gene that causes Wolfram syndrome in the Druze population by Inbal Halabi, Inbal Halabi, Yardena Tenenbaum-Rakover, Yardena Tenenbaum-Rakover, Lena Sagi-Dain, Lena Sagi-Dain, Lena Sagi-Dain, Ilana Koren, Ilana Koren, Ilana Koren

“…Early diagnosis of WS is important for therapeutic approaches, especially since novel medications are becoming available.…”
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Biofilmed-PGPR: Next-Generation Bioinoculant for Plant Growth Promotion in Rice under Changing Climate by Jeberlin Prabina Bright, Hemant S. Maheshwari, Sugitha Thangappan, Kahkashan Perveen, Najat A. Bukhari, Debasis Mitra, Riyaz Sayyed, Andrea Mastinu

“…We concluded that CBB could be used as a novel biofilm-based bio-inoculant to increase rice productivity and crop fitness as a component in integrated nutrient management and sustainable organic farming strategies with reduced chemical fertilizers.…”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Herein, we proposed a novel approach to modulate the inflammation through metabolic remodeling, thus promoting dry eye recovery. …”
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Dissecting Causal Relationships Between Antihypertensive Drug, Gut Microbiota, and Type 2 Diabetes Mellitus and Its Complications: A Mendelian Randomization Study by He Zheng, Shiping Wu, Wenbin Wang, Weida Qiu, Yingqing Feng

“…Colocalization supports these results (KCNJ11: 98% for diabetic retinopathy; SLC12A2: 99% for T2DM). Findings provide novel targets for the treatment of T2DM and its complications, emphasize the importance of KCNJ11 and SLC12A2 in future drug development, and highlight the significant mediating role of the genus Ruminococcus.…”
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Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma by Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D. Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M. Ametamey, Daniel Eberli

“…In summary, we facilitated early functional muscle tissue regeneration, introducing a novel approach to improve skeletal muscle regeneration. …”
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Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus by Qingjun Pan, Linjie Guo, Jing Wu, Jun Cai, Huanjin Liao, Qiaofen Lan, Yanxia Peng, Yiming He, Hua-feng Liu

“…In summary, the IgG4 autoantibody may dampen the inflammatory response in SLE, thus maybe providing a novel therapeutic target for SLE.…”
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Rubber intercropping with arboreal and herbaceous species alleviated the global warming potential through the reduction of soil greenhouse gas emissions by Tahir Ashar, Yingying Zhang, Chuan Yang, Wenxian Xu, Muhammad Zeeshan Ul Haq, Hassam Tahir, Hafiz Muhammad Mazhar Abbas, Zhixiang Wu

“…The soil DOC concentration was the primary factor influencing GHG emissions and GWP. This study provides novel insights into GHG emissions from rubber agroforestry systems and serves as a fundamental reference for climate-smart land use management in rubber plantations. …”
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Cell-free DNA release following psychosocial and physical stress in women and men by A. S. Limberg, F. Berg, E. Köper, C. Lindgraf, C. Gevers, R. Kumsta, E. M. Hummel, D. A. Moser

“…In addition, cf-nDNA and cf-mtDNA were comparatively quantified in both plasma and saliva at four time points, 2 min before and 2, 15, and 45 min after stress induction. A novel method was implemented to facilitate the straightforward collection of capillary blood by non-medical personnel for plasma analysis. …”
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Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors by Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian

“…Background: The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics. …”
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Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects by Yueyi Yang, Jing Huang, Xuchen Hu, Meiling Jing, Yujie Zhang, Chenci Xu, Wenduo Tan, Xiaoyu Liu, Chenguang Niu, Zhengwei Huang

“…Surface prereacted glass ionomer (S-PRG) is a novel glass particle characterized by a three-layered structure and the release of multiple ions with bioactive potential. …”
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Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…Our results suggest that SSA contains bioactive compounds that may originate from marine algae and modulate cellular processes related to human health. We provide novel insights into the molecular effects of SSA exposure and highlight its potential as a source of natural therapeutics. …”
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A Retrospective Analysis of Thromboembolic Phenomena in Mechanically Ventilated Patients with COVID-19 by Fahad Faqihi, Abdulrahman Alharthy, Abdullah Balhamar, Nasir Nasim, Khaled Alanezi, Feisal Alaklobi, Ziad A. Memish, Mike Blaivas, Saleh A. Alqahtani, Dimitrios Karakitsos

“…Recent studies have shown an increased prevalence of thromboembolic disease in critically ill patients with the novel SARS-CoV-2 disease (COVID-19). However, the use of enhanced anticoagulation therapy in these patients remains controversial. …”
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Advancing soil-structure interaction (SSI): a comprehensive review of current practices, challenges, and future directions by Imtiyaz Akbar Najar, Raudhah Ahmadi, Akeem Gbenga Amuda, Raghad Mourad, Neveen El Bendary, Idawati Ismail, Nabilah Abu Bakar, Shanshan Tang

“…It concludes with a call for interdisciplinary collaboration and future research into novel SSI applications, including its integration with smart sensing technologies and sustainable infrastructure design. …”
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